Lack of antidiabetic effect of a Eugenia jambolana leaf decoction on rat streptozotocin diabetes

Lack of antidiabetic effect of a Eugenia jambolana leaf decoction on rat streptozotocin diabetes

Streptozotocin-diabetic rats were treated for 17 days with a decoction of Eugenia jambolana (Myrtaceae) leaves (15%, w/v) as a substitute for water. Body weight, food and fluid intake, urine volume, glycemia, urinary glucose and urea were evaluated every 5 days. The animals were sacrificed by decapitation and blood samples collected for the determination of glycemia, serum cholesterol, HDL-cholesterol, triglycerides and angiotensin-converting enzyme. The weight of adipose and muscle tissues was also determined. There were no statistically significant differences between treated and untreated rats for any of the biochemical or physiological parameters. We conclude that, at least in this experimental model, Eugenia jambolana leaf decoction has no antidiabetic activity.

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Main Authors: Pepato,M.T., Folgado,V.B.B., Kettelhut,I.C., Brunetti,I.L.
Format: Digital revista
Language:English
Published: Associação Brasileira de Divulgação Científica 2001
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300014
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spelling oai:scielo:S0100-879X20010003000142001-03-16Lack of antidiabetic effect of a Eugenia jambolana leaf decoction on rat streptozotocin diabetesPepato,M.T.Folgado,V.B.B.Kettelhut,I.C.Brunetti,I.L. antidiabetic plant hyperglycemia diabetic rats Eugenia jambolana Streptozotocin-diabetic rats were treated for 17 days with a decoction of Eugenia jambolana (Myrtaceae) leaves (15%, w/v) as a substitute for water. Body weight, food and fluid intake, urine volume, glycemia, urinary glucose and urea were evaluated every 5 days. The animals were sacrificed by decapitation and blood samples collected for the determination of glycemia, serum cholesterol, HDL-cholesterol, triglycerides and angiotensin-converting enzyme. The weight of adipose and muscle tissues was also determined. There were no statistically significant differences between treated and untreated rats for any of the biochemical or physiological parameters. We conclude that, at least in this experimental model, Eugenia jambolana leaf decoction has no antidiabetic activity.info:eu-repo/semantics/openAccessAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research v.34 n.3 20012001-03-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300014en10.1590/S0100-879X2001000300014
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country Brasil
countrycode BR
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region America del Sur
libraryname SciELO
language English
format Digital
author Pepato,M.T.
Folgado,V.B.B.
Kettelhut,I.C.
Brunetti,I.L.
spellingShingle Pepato,M.T.
Folgado,V.B.B.
Kettelhut,I.C.
Brunetti,I.L.
Lack of antidiabetic effect of a Eugenia jambolana leaf decoction on rat streptozotocin diabetes
author_facet Pepato,M.T.
Folgado,V.B.B.
Kettelhut,I.C.
Brunetti,I.L.
author_sort Pepato,M.T.
title Lack of antidiabetic effect of a Eugenia jambolana leaf decoction on rat streptozotocin diabetes
title_short Lack of antidiabetic effect of a Eugenia jambolana leaf decoction on rat streptozotocin diabetes
title_full Lack of antidiabetic effect of a Eugenia jambolana leaf decoction on rat streptozotocin diabetes
title_fullStr Lack of antidiabetic effect of a Eugenia jambolana leaf decoction on rat streptozotocin diabetes
title_full_unstemmed Lack of antidiabetic effect of a Eugenia jambolana leaf decoction on rat streptozotocin diabetes
title_sort lack of antidiabetic effect of a eugenia jambolana leaf decoction on rat streptozotocin diabetes
description Streptozotocin-diabetic rats were treated for 17 days with a decoction of Eugenia jambolana (Myrtaceae) leaves (15%, w/v) as a substitute for water. Body weight, food and fluid intake, urine volume, glycemia, urinary glucose and urea were evaluated every 5 days. The animals were sacrificed by decapitation and blood samples collected for the determination of glycemia, serum cholesterol, HDL-cholesterol, triglycerides and angiotensin-converting enzyme. The weight of adipose and muscle tissues was also determined. There were no statistically significant differences between treated and untreated rats for any of the biochemical or physiological parameters. We conclude that, at least in this experimental model, Eugenia jambolana leaf decoction has no antidiabetic activity.
publisher Associação Brasileira de Divulgação Científica
publishDate 2001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300014
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AT folgadovbb lackofantidiabeticeffectofaeugeniajambolanaleafdecoctiononratstreptozotocindiabetes
AT kettelhutic lackofantidiabeticeffectofaeugeniajambolanaleafdecoctiononratstreptozotocindiabetes
AT brunettiil lackofantidiabeticeffectofaeugeniajambolanaleafdecoctiononratstreptozotocindiabetes
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