Effect of taxol on chromosome aberrations induced by gamma radiation or by doxorubicin in Chinese hamster ovary cells

Effect of taxol on chromosome aberrations induced by gamma radiation or by doxorubicin in Chinese hamster ovary cells

Combined therapy with radiation and chemotherapy has being increasingly used in cancer treatment. The effect of combinations of taxol (0.08 mug/ml) with doxorubicin (DXR, 0.5 or 1.0 mug/ml) or gamma radiation (20 or 40 cGy) was examined in two different treatment schedules (pretreatment or simultaneous treatment) using Chinese hamster ovary (CHO) cells treated at the G2 phase of the cell cycle. The results showed that taxol did not have a radiosensitizing effect on the chromosomal aberrations induced by gamma radiation nor did it have a potentiating effect on the chromosomal aberrations induced by DXR in CHO cells treated in the G2 phase of the cell cycle

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Main Authors: Dias,Francisca da Luz, Antunes,Lusânia M.G., Takahashi,Catarina S.
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Genética 1997
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84551997000300006
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spelling oai:scielo:S0100-845519970003000061998-10-06Effect of taxol on chromosome aberrations induced by gamma radiation or by doxorubicin in Chinese hamster ovary cellsDias,Francisca da LuzAntunes,Lusânia M.G.Takahashi,Catarina S.Combined therapy with radiation and chemotherapy has being increasingly used in cancer treatment. The effect of combinations of taxol (0.08 mug/ml) with doxorubicin (DXR, 0.5 or 1.0 mug/ml) or gamma radiation (20 or 40 cGy) was examined in two different treatment schedules (pretreatment or simultaneous treatment) using Chinese hamster ovary (CHO) cells treated at the G2 phase of the cell cycle. The results showed that taxol did not have a radiosensitizing effect on the chromosomal aberrations induced by gamma radiation nor did it have a potentiating effect on the chromosomal aberrations induced by DXR in CHO cells treated in the G2 phase of the cell cycleinfo:eu-repo/semantics/openAccessSociedade Brasileira de GenéticaBrazilian Journal of Genetics v.20 n.3 19971997-09-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84551997000300006en10.1590/S0100-84551997000300006
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Dias,Francisca da Luz
Antunes,Lusânia M.G.
Takahashi,Catarina S.
spellingShingle Dias,Francisca da Luz
Antunes,Lusânia M.G.
Takahashi,Catarina S.
Effect of taxol on chromosome aberrations induced by gamma radiation or by doxorubicin in Chinese hamster ovary cells
author_facet Dias,Francisca da Luz
Antunes,Lusânia M.G.
Takahashi,Catarina S.
author_sort Dias,Francisca da Luz
title Effect of taxol on chromosome aberrations induced by gamma radiation or by doxorubicin in Chinese hamster ovary cells
title_short Effect of taxol on chromosome aberrations induced by gamma radiation or by doxorubicin in Chinese hamster ovary cells
title_full Effect of taxol on chromosome aberrations induced by gamma radiation or by doxorubicin in Chinese hamster ovary cells
title_fullStr Effect of taxol on chromosome aberrations induced by gamma radiation or by doxorubicin in Chinese hamster ovary cells
title_full_unstemmed Effect of taxol on chromosome aberrations induced by gamma radiation or by doxorubicin in Chinese hamster ovary cells
title_sort effect of taxol on chromosome aberrations induced by gamma radiation or by doxorubicin in chinese hamster ovary cells
description Combined therapy with radiation and chemotherapy has being increasingly used in cancer treatment. The effect of combinations of taxol (0.08 mug/ml) with doxorubicin (DXR, 0.5 or 1.0 mug/ml) or gamma radiation (20 or 40 cGy) was examined in two different treatment schedules (pretreatment or simultaneous treatment) using Chinese hamster ovary (CHO) cells treated at the G2 phase of the cell cycle. The results showed that taxol did not have a radiosensitizing effect on the chromosomal aberrations induced by gamma radiation nor did it have a potentiating effect on the chromosomal aberrations induced by DXR in CHO cells treated in the G2 phase of the cell cycle
publisher Sociedade Brasileira de Genética
publishDate 1997
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84551997000300006
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AT antuneslusaniamg effectoftaxolonchromosomeaberrationsinducedbygammaradiationorbydoxorubicininchinesehamsterovarycells
AT takahashicatarinas effectoftaxolonchromosomeaberrationsinducedbygammaradiationorbydoxorubicininchinesehamsterovarycells
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