Atividade antibacteriana in vitro e toxicidade frente à Artemia salina Leach. de alguns compostos triazenos
Bacterial resistance to antibacterial agents is currently a major concern. We report the synthesis, in vitro antibacterial activity and toxicity toward Artemia salina of six diaryltriazene compounds bearing different substituent groups. Minimal Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) values against standard strains (ATCC) and clinical isolates (including ESBL, MBL and AmpC strains) were good to very good, in the range 8 to 128 mg mL-1. Results suggest that hydroxyl, 4-carboxyl and 4-phenyldiazenil groups attached to the diaryltriazenes provide enhanced activity. Toxicity results showed very low LC50 values for three compounds (10-fold lower than DTIC).
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Sociedade Brasileira de Química
2014
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oai:scielo:S0100-404220140007000062014-08-26Atividade antibacteriana in vitro e toxicidade frente à Artemia salina Leach. de alguns compostos triazenosParaginski,Gustavo LuizBerticelli,Claiton RobertoZambiazi,Priscilla JussianiParaginski,Vanessa Teixeira KunzHörner,ManfredoSantos,Aline Joana Rolina Wohlmuth Alves dosHörner,Rosmari triazene biological activity multidrug-resistant isolates Bacterial resistance to antibacterial agents is currently a major concern. We report the synthesis, in vitro antibacterial activity and toxicity toward Artemia salina of six diaryltriazene compounds bearing different substituent groups. Minimal Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) values against standard strains (ATCC) and clinical isolates (including ESBL, MBL and AmpC strains) were good to very good, in the range 8 to 128 mg mL-1. Results suggest that hydroxyl, 4-carboxyl and 4-phenyldiazenil groups attached to the diaryltriazenes provide enhanced activity. Toxicity results showed very low LC50 values for three compounds (10-fold lower than DTIC).info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaQuímica Nova v.37 n.7 20142014-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000700006pt10.5935/0100-4042.20140180 |
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Paraginski,Gustavo Luiz Berticelli,Claiton Roberto Zambiazi,Priscilla Jussiani Paraginski,Vanessa Teixeira Kunz Hörner,Manfredo Santos,Aline Joana Rolina Wohlmuth Alves dos Hörner,Rosmari |
| spellingShingle |
Paraginski,Gustavo Luiz Berticelli,Claiton Roberto Zambiazi,Priscilla Jussiani Paraginski,Vanessa Teixeira Kunz Hörner,Manfredo Santos,Aline Joana Rolina Wohlmuth Alves dos Hörner,Rosmari Atividade antibacteriana in vitro e toxicidade frente à Artemia salina Leach. de alguns compostos triazenos |
| author_facet |
Paraginski,Gustavo Luiz Berticelli,Claiton Roberto Zambiazi,Priscilla Jussiani Paraginski,Vanessa Teixeira Kunz Hörner,Manfredo Santos,Aline Joana Rolina Wohlmuth Alves dos Hörner,Rosmari |
| author_sort |
Paraginski,Gustavo Luiz |
| title |
Atividade antibacteriana in vitro e toxicidade frente à Artemia salina Leach. de alguns compostos triazenos |
| title_short |
Atividade antibacteriana in vitro e toxicidade frente à Artemia salina Leach. de alguns compostos triazenos |
| title_full |
Atividade antibacteriana in vitro e toxicidade frente à Artemia salina Leach. de alguns compostos triazenos |
| title_fullStr |
Atividade antibacteriana in vitro e toxicidade frente à Artemia salina Leach. de alguns compostos triazenos |
| title_full_unstemmed |
Atividade antibacteriana in vitro e toxicidade frente à Artemia salina Leach. de alguns compostos triazenos |
| title_sort |
atividade antibacteriana in vitro e toxicidade frente à artemia salina leach. de alguns compostos triazenos |
| description |
Bacterial resistance to antibacterial agents is currently a major concern. We report the synthesis, in vitro antibacterial activity and toxicity toward Artemia salina of six diaryltriazene compounds bearing different substituent groups. Minimal Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) values against standard strains (ATCC) and clinical isolates (including ESBL, MBL and AmpC strains) were good to very good, in the range 8 to 128 mg mL-1. Results suggest that hydroxyl, 4-carboxyl and 4-phenyldiazenil groups attached to the diaryltriazenes provide enhanced activity. Toxicity results showed very low LC50 values for three compounds (10-fold lower than DTIC). |
| publisher |
Sociedade Brasileira de Química |
| publishDate |
2014 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000700006 |
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