Schistosoma mansoni: control of female fertility by the male

Schistosoma mansoni: control of female fertility by the male

We have established an in vitro culture system for adult schistosomes that allows monitoring gene expression for up to more than ten days. Comparing female worms that are paired with those that have been separated, we find distinct differences, clearly documenting an influence of the male in female gene expression. In perfect coincidence with classical observations that were based on histological techniques, we find that the male particularly regulates gene expression in those tissues that are characterized by cell proliferation, e.g. the vitellaria. From these results, we hypothesize that the key target for the inductive signal that is transferred from the male to the female during pairing is the activation of a growth factor that stimulates mitotic proliferation.

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Main Authors: Kunz,Werner, Gohr,Lutz, Grevelding,Christoph, Schüssler,Peter, Sommer,Gabriele, Menrath,Marion, Michel,Anja
Format: Digital revista
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 1995
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761995000200010
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spelling oai:scielo:S0074-027619950002000102009-06-01Schistosoma mansoni: control of female fertility by the maleKunz,WernerGohr,LutzGrevelding,ChristophSchüssler,PeterSommer,GabrieleMenrath,MarionMichel,Anja Schistosoma mansoni in vitro culture gene expression male female interaction We have established an in vitro culture system for adult schistosomes that allows monitoring gene expression for up to more than ten days. Comparing female worms that are paired with those that have been separated, we find distinct differences, clearly documenting an influence of the male in female gene expression. In perfect coincidence with classical observations that were based on histological techniques, we find that the male particularly regulates gene expression in those tissues that are characterized by cell proliferation, e.g. the vitellaria. From these results, we hypothesize that the key target for the inductive signal that is transferred from the male to the female during pairing is the activation of a growth factor that stimulates mitotic proliferation.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.90 n.2 19951995-04-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761995000200010en10.1590/S0074-02761995000200010
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Kunz,Werner
Gohr,Lutz
Grevelding,Christoph
Schüssler,Peter
Sommer,Gabriele
Menrath,Marion
Michel,Anja
spellingShingle Kunz,Werner
Gohr,Lutz
Grevelding,Christoph
Schüssler,Peter
Sommer,Gabriele
Menrath,Marion
Michel,Anja
Schistosoma mansoni: control of female fertility by the male
author_facet Kunz,Werner
Gohr,Lutz
Grevelding,Christoph
Schüssler,Peter
Sommer,Gabriele
Menrath,Marion
Michel,Anja
author_sort Kunz,Werner
title Schistosoma mansoni: control of female fertility by the male
title_short Schistosoma mansoni: control of female fertility by the male
title_full Schistosoma mansoni: control of female fertility by the male
title_fullStr Schistosoma mansoni: control of female fertility by the male
title_full_unstemmed Schistosoma mansoni: control of female fertility by the male
title_sort schistosoma mansoni: control of female fertility by the male
description We have established an in vitro culture system for adult schistosomes that allows monitoring gene expression for up to more than ten days. Comparing female worms that are paired with those that have been separated, we find distinct differences, clearly documenting an influence of the male in female gene expression. In perfect coincidence with classical observations that were based on histological techniques, we find that the male particularly regulates gene expression in those tissues that are characterized by cell proliferation, e.g. the vitellaria. From these results, we hypothesize that the key target for the inductive signal that is transferred from the male to the female during pairing is the activation of a growth factor that stimulates mitotic proliferation.
publisher Instituto Oswaldo Cruz, Ministério da Saúde
publishDate 1995
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761995000200010
work_keys_str_mv AT kunzwerner schistosomamansonicontroloffemalefertilitybythemale
AT gohrlutz schistosomamansonicontroloffemalefertilitybythemale
AT greveldingchristoph schistosomamansonicontroloffemalefertilitybythemale
AT schusslerpeter schistosomamansonicontroloffemalefertilitybythemale
AT sommergabriele schistosomamansonicontroloffemalefertilitybythemale
AT menrathmarion schistosomamansonicontroloffemalefertilitybythemale
AT michelanja schistosomamansonicontroloffemalefertilitybythemale
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