EVI antibodies in patients with Chagas' disease: relationship with anti-Trypanosoma cruzi immunoglobulins and effects of specific treatment
Antibodies against heart vascular structures and striated muscle cells interstitium (EVI antibodies) persist in Chagas' disease patients who had been cured by specific treatment as demonstrated by negative xenodiagnosis, conventional serology (CS) and complement mediated lysis (CoML). On the other hand, EVI antibodies are either present or absent in treated patients presenting positive CS but negative CoML. Since CoML detects antibodies associated to resistance, EVI antibodies are not likely to participate in the control of T. cruzi infections although they might be induced by cross-reacting antigens of heart cells and the parasite. They are neither necessarily related to antibodies responsible for CS. Absorption with T. cruzi and heart tissue confirms the suggestion that EVI antibodies are induced by a number of antigenic determinants, most from heart structures with a minor participation of T. cruzi antigens.
Main Authors: | Brener,Z., Ramirez,L. E., Krettli,A. U., Cançado,J. R. |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Instituto Oswaldo Cruz, Ministério da Saúde
1983
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761983000400007 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The utility of anti-trypomastigote lytic antibodies for determining cure of Trypanosoma cruzi infections in treated patients: an overview and perspectives
by: Krettli,Antoniana Ursine
Published: (2009) -
Relationship of parasite specific antibodies and heart specific autoantibodies in mice infected with Trypanosoma cruzi
by: Rowland,Edwin C., et al.
Published: (1988) -
Specific and sensitive immunological diagnosis of Chagas'disease by competitive antibody enzime immunoassay using a Trypanosoma cruzi-specific monoclonal antibody
by: Lemesre, JL, et al.
Published: (1986) -
Criterion of cure of human Chagas' disease after specific chemotherapy: recent advances
by: Krettli,Antoniana Ursine, et al.
Published: (1984) -
Persistent infections in chronic Chagas' disease patients treated with anti-Trypanosoma cruzi nitroderivatives
by: BRAGA,M. Socorro, et al.
Published: (2000)