COVID-19 presenting as acute generalized exanthematous pustulosis associated with multiorgan dysfunction in a 44-year-old female patient

ABSTRACT Acute generalised exanthematous pustulosis (AGEP) is an unusual cutaneous reaction, most often related with a hypersensitivity reaction to commonly used drugs. It is characterized by an abrupt onset of a pustular rash within hours or days after drug exposure and usually resolves spontaneously within 1-2 weeks after drug discontinuation. Some cases associated with systemic involvement and shock have been reported. We present the case of a severe AGEP, manifesting in association with systemic involvement and haemodynamic instability resulting in shock and multiorgan dysfunction in an adult female patient diagnosed with COVID-19 infection. There were no identifiable associated drugs, and the patient was not initiated on antimalarial drugs. Our patient improved rapidly, both hemodynamically and dermatologically with no directed therapy.

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Main Authors: Ordoñez,Nicolás Ariza, Sepulveda,Valeria Gomez, Vargas,Lina Patricia, Moreno,Julian Mauricio
Format: Digital revista
Language:English
Published: Instituto de Medicina Tropical de São Paulo 2021
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652021000100507
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spelling oai:scielo:S0036-466520210001005072021-05-20COVID-19 presenting as acute generalized exanthematous pustulosis associated with multiorgan dysfunction in a 44-year-old female patientOrdoñez,Nicolás ArizaSepulveda,Valeria GomezVargas,Lina PatriciaMoreno,Julian Mauricio COVID-19 Skin manifestations SARS CoV-2 Shock ABSTRACT Acute generalised exanthematous pustulosis (AGEP) is an unusual cutaneous reaction, most often related with a hypersensitivity reaction to commonly used drugs. It is characterized by an abrupt onset of a pustular rash within hours or days after drug exposure and usually resolves spontaneously within 1-2 weeks after drug discontinuation. Some cases associated with systemic involvement and shock have been reported. We present the case of a severe AGEP, manifesting in association with systemic involvement and haemodynamic instability resulting in shock and multiorgan dysfunction in an adult female patient diagnosed with COVID-19 infection. There were no identifiable associated drugs, and the patient was not initiated on antimalarial drugs. Our patient improved rapidly, both hemodynamically and dermatologically with no directed therapy.info:eu-repo/semantics/openAccessInstituto de Medicina Tropical de São PauloRevista do Instituto de Medicina Tropical de São Paulo v.63 20212021-01-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652021000100507en10.1590/s1678-9946202163042
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country Brasil
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region America del Sur
libraryname SciELO
language English
format Digital
author Ordoñez,Nicolás Ariza
Sepulveda,Valeria Gomez
Vargas,Lina Patricia
Moreno,Julian Mauricio
spellingShingle Ordoñez,Nicolás Ariza
Sepulveda,Valeria Gomez
Vargas,Lina Patricia
Moreno,Julian Mauricio
COVID-19 presenting as acute generalized exanthematous pustulosis associated with multiorgan dysfunction in a 44-year-old female patient
author_facet Ordoñez,Nicolás Ariza
Sepulveda,Valeria Gomez
Vargas,Lina Patricia
Moreno,Julian Mauricio
author_sort Ordoñez,Nicolás Ariza
title COVID-19 presenting as acute generalized exanthematous pustulosis associated with multiorgan dysfunction in a 44-year-old female patient
title_short COVID-19 presenting as acute generalized exanthematous pustulosis associated with multiorgan dysfunction in a 44-year-old female patient
title_full COVID-19 presenting as acute generalized exanthematous pustulosis associated with multiorgan dysfunction in a 44-year-old female patient
title_fullStr COVID-19 presenting as acute generalized exanthematous pustulosis associated with multiorgan dysfunction in a 44-year-old female patient
title_full_unstemmed COVID-19 presenting as acute generalized exanthematous pustulosis associated with multiorgan dysfunction in a 44-year-old female patient
title_sort covid-19 presenting as acute generalized exanthematous pustulosis associated with multiorgan dysfunction in a 44-year-old female patient
description ABSTRACT Acute generalised exanthematous pustulosis (AGEP) is an unusual cutaneous reaction, most often related with a hypersensitivity reaction to commonly used drugs. It is characterized by an abrupt onset of a pustular rash within hours or days after drug exposure and usually resolves spontaneously within 1-2 weeks after drug discontinuation. Some cases associated with systemic involvement and shock have been reported. We present the case of a severe AGEP, manifesting in association with systemic involvement and haemodynamic instability resulting in shock and multiorgan dysfunction in an adult female patient diagnosed with COVID-19 infection. There were no identifiable associated drugs, and the patient was not initiated on antimalarial drugs. Our patient improved rapidly, both hemodynamically and dermatologically with no directed therapy.
publisher Instituto de Medicina Tropical de São Paulo
publishDate 2021
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652021000100507
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