Virulence factors and genetic variability of vaginal Candida albicans isolates from HIV-infected women in the post-highly active antiretroviral era
ABSTRACT Vulvovaginal candidiasis (VVC) in HIV-infected (HIV+) women is a serious public health problem. However, little is known about the virulence mechanisms of vaginal Candida albicans from HIV+ women in the post-highly active antiretroviral therapy (HAART) era. Here, we report a comparative analysis of the expression of key virulence factors and genetic variability of 26 vaginal C. albicans strains isolated from HIV+ women undergoing HAART and 18 from HIV-uninfected (HIV-) women. In general, we observed that C. albicans from HIV+ women receiving HAART showed lower expression of virulence factors compared with C. albicans from HIV- women, except for the proteinase activity which is highly expressed. The results in HIV-women further suggest that virulence factors appear to be expressed in response to the yeast stress, in the presence of an adequate immune response. Furthermore, the RAPD results showed a high heterogeneity among isolates from both groups of women. These findings in HIV+ women using HAART will help to improve the monitoring of vaginal yeast infections and the quality of life of patients.
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Instituto de Medicina Tropical de São Paulo
2017
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oai:scielo:S0036-466520170050002222017-08-01Virulence factors and genetic variability of vaginal Candida albicans isolates from HIV-infected women in the post-highly active antiretroviral eraZanni,Pâmela Cristina Mastellaro DelvasBonfim-Mendonça,Patrícia de SouzaNegri,MelyssaNakamura,Sandra SayuriDonatti,LucéliaSvidzinski,Terezinha Inez EstivaletConsolaro,Márcia Edilaine Lopes Vulvovaginal candidiasis. Candida albicans HIV Virulence Genetic variability ABSTRACT Vulvovaginal candidiasis (VVC) in HIV-infected (HIV+) women is a serious public health problem. However, little is known about the virulence mechanisms of vaginal Candida albicans from HIV+ women in the post-highly active antiretroviral therapy (HAART) era. Here, we report a comparative analysis of the expression of key virulence factors and genetic variability of 26 vaginal C. albicans strains isolated from HIV+ women undergoing HAART and 18 from HIV-uninfected (HIV-) women. In general, we observed that C. albicans from HIV+ women receiving HAART showed lower expression of virulence factors compared with C. albicans from HIV- women, except for the proteinase activity which is highly expressed. The results in HIV-women further suggest that virulence factors appear to be expressed in response to the yeast stress, in the presence of an adequate immune response. Furthermore, the RAPD results showed a high heterogeneity among isolates from both groups of women. These findings in HIV+ women using HAART will help to improve the monitoring of vaginal yeast infections and the quality of life of patients.info:eu-repo/semantics/openAccessInstituto de Medicina Tropical de São PauloRevista do Instituto de Medicina Tropical de São Paulo v.59 20172017-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652017005000222en10.1590/s1678-9946201759044 |
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Zanni,Pâmela Cristina Mastellaro Delvas Bonfim-Mendonça,Patrícia de Souza Negri,Melyssa Nakamura,Sandra Sayuri Donatti,Lucélia Svidzinski,Terezinha Inez Estivalet Consolaro,Márcia Edilaine Lopes |
| spellingShingle |
Zanni,Pâmela Cristina Mastellaro Delvas Bonfim-Mendonça,Patrícia de Souza Negri,Melyssa Nakamura,Sandra Sayuri Donatti,Lucélia Svidzinski,Terezinha Inez Estivalet Consolaro,Márcia Edilaine Lopes Virulence factors and genetic variability of vaginal Candida albicans isolates from HIV-infected women in the post-highly active antiretroviral era |
| author_facet |
Zanni,Pâmela Cristina Mastellaro Delvas Bonfim-Mendonça,Patrícia de Souza Negri,Melyssa Nakamura,Sandra Sayuri Donatti,Lucélia Svidzinski,Terezinha Inez Estivalet Consolaro,Márcia Edilaine Lopes |
| author_sort |
Zanni,Pâmela Cristina Mastellaro Delvas |
| title |
Virulence factors and genetic variability of vaginal Candida albicans isolates from HIV-infected women in the post-highly active antiretroviral era |
| title_short |
Virulence factors and genetic variability of vaginal Candida albicans isolates from HIV-infected women in the post-highly active antiretroviral era |
| title_full |
Virulence factors and genetic variability of vaginal Candida albicans isolates from HIV-infected women in the post-highly active antiretroviral era |
| title_fullStr |
Virulence factors and genetic variability of vaginal Candida albicans isolates from HIV-infected women in the post-highly active antiretroviral era |
| title_full_unstemmed |
Virulence factors and genetic variability of vaginal Candida albicans isolates from HIV-infected women in the post-highly active antiretroviral era |
| title_sort |
virulence factors and genetic variability of vaginal candida albicans isolates from hiv-infected women in the post-highly active antiretroviral era |
| description |
ABSTRACT Vulvovaginal candidiasis (VVC) in HIV-infected (HIV+) women is a serious public health problem. However, little is known about the virulence mechanisms of vaginal Candida albicans from HIV+ women in the post-highly active antiretroviral therapy (HAART) era. Here, we report a comparative analysis of the expression of key virulence factors and genetic variability of 26 vaginal C. albicans strains isolated from HIV+ women undergoing HAART and 18 from HIV-uninfected (HIV-) women. In general, we observed that C. albicans from HIV+ women receiving HAART showed lower expression of virulence factors compared with C. albicans from HIV- women, except for the proteinase activity which is highly expressed. The results in HIV-women further suggest that virulence factors appear to be expressed in response to the yeast stress, in the presence of an adequate immune response. Furthermore, the RAPD results showed a high heterogeneity among isolates from both groups of women. These findings in HIV+ women using HAART will help to improve the monitoring of vaginal yeast infections and the quality of life of patients. |
| publisher |
Instituto de Medicina Tropical de São Paulo |
| publishDate |
2017 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652017005000222 |
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