Glioma difuso de línea media H3K27M positivo en adulto. Caso clínico
^aThe 2016 WHO Classification of Tumours of the Central Nervous System incorporates a new diagnostic entity: the mutant diffuse midline glioma H3K27, a tumor with a characteristic location and special molecular biology. We report the case of a 51-year-old male patient with progressive diplopia. The imaging study showed a mesencephalic tumor; the stereotacic biopsy disclosed an Anaplastic Astrocytoma Isocitrate dehydrogenase (IDH) wild type. The molecular study concludes H3K27 mutation. The patient was treated with radiotherapy with concurrent and adjuvant chemotherapy (temozolomide) with partial recovery of the diplopia.
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| Format: | Digital revista |
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Sociedad Médica de Santiago
2019
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| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001101487 |
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oai:scielo:S0034-988720190011014872020-02-25Glioma difuso de línea media H3K27M positivo en adulto. Caso clínicoARANEDA,PATRICIASUJIMA,EMIPAREDES-MANZO,PATRICIOVALLEJO,RODRIGOVALDIVIA,FELIPESINNING,MARIANAGALLEGOS,MARCELAFULLER,GREGORY Astrocytoma Glioma Histones ^aThe 2016 WHO Classification of Tumours of the Central Nervous System incorporates a new diagnostic entity: the mutant diffuse midline glioma H3K27, a tumor with a characteristic location and special molecular biology. We report the case of a 51-year-old male patient with progressive diplopia. The imaging study showed a mesencephalic tumor; the stereotacic biopsy disclosed an Anaplastic Astrocytoma Isocitrate dehydrogenase (IDH) wild type. The molecular study concludes H3K27 mutation. The patient was treated with radiotherapy with concurrent and adjuvant chemotherapy (temozolomide) with partial recovery of the diplopia.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.147 n.11 20192019-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001101487es10.4067/S0034-98872019001101487 |
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America del Sur |
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| language |
Spanish / Castilian |
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Digital |
| author |
ARANEDA,PATRICIA SUJIMA,EMI PAREDES-MANZO,PATRICIO VALLEJO,RODRIGO VALDIVIA,FELIPE SINNING,MARIANA GALLEGOS,MARCELA FULLER,GREGORY |
| spellingShingle |
ARANEDA,PATRICIA SUJIMA,EMI PAREDES-MANZO,PATRICIO VALLEJO,RODRIGO VALDIVIA,FELIPE SINNING,MARIANA GALLEGOS,MARCELA FULLER,GREGORY Glioma difuso de línea media H3K27M positivo en adulto. Caso clínico |
| author_facet |
ARANEDA,PATRICIA SUJIMA,EMI PAREDES-MANZO,PATRICIO VALLEJO,RODRIGO VALDIVIA,FELIPE SINNING,MARIANA GALLEGOS,MARCELA FULLER,GREGORY |
| author_sort |
ARANEDA,PATRICIA |
| title |
Glioma difuso de línea media H3K27M positivo en adulto. Caso clínico |
| title_short |
Glioma difuso de línea media H3K27M positivo en adulto. Caso clínico |
| title_full |
Glioma difuso de línea media H3K27M positivo en adulto. Caso clínico |
| title_fullStr |
Glioma difuso de línea media H3K27M positivo en adulto. Caso clínico |
| title_full_unstemmed |
Glioma difuso de línea media H3K27M positivo en adulto. Caso clínico |
| title_sort |
glioma difuso de línea media h3k27m positivo en adulto. caso clínico |
| description |
^aThe 2016 WHO Classification of Tumours of the Central Nervous System incorporates a new diagnostic entity: the mutant diffuse midline glioma H3K27, a tumor with a characteristic location and special molecular biology. We report the case of a 51-year-old male patient with progressive diplopia. The imaging study showed a mesencephalic tumor; the stereotacic biopsy disclosed an Anaplastic Astrocytoma Isocitrate dehydrogenase (IDH) wild type. The molecular study concludes H3K27 mutation. The patient was treated with radiotherapy with concurrent and adjuvant chemotherapy (temozolomide) with partial recovery of the diplopia. |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2019 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001101487 |
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