Decreased health-related quality of life in children and adolescents with autoimmune hepatitis
Abstract Objective: The objective of this study was to evaluate the health-related quality of life in children and adolescents with autoimmune hepatitis. Methods: A cross-sectional assessment with the Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0) was completed for 80 patients with autoimmune hepatitis and 45 healthy controls. Demographic data, prednisone dose, disease remission state, disease severity, and abdominal pain were also evaluated. Results: Based on the child self-reports, physical, emotional, school, and total scores were significantly lower in autoimmune hepatitis patients when compared with controls (p < 0.05). Based on the parental reports, only the physical and total scores were significantly lower in autoimmune hepatitis patients versus controls (p < 0.05). Further analysis in autoimmune hepatitis patients with abdominal pain in the last month revealed significantly lower physical, social, and total median scores (p < 0.05). No differences were observed based on disease remission state or disease severity (p > 0.05). Autoimmune hepatitis patients who received a prednisone dose below 0.16 mg/kg/day at the time of the interview showed significantly higher physical scores than those who received a dose similar to or above 0.16 mg/kg/day (87.5 [50–100] vs. 75 [15.63–100], p = 0.006). Conclusions: Reduced scores in the physical, emotional, and school domains were observed in pediatric autoimmune hepatitis patients compared to control patients. Abdominal pain and corticosteroid dose negatively influenced the health-related quality of life in children and adolescents with autoimmune hepatitis.
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Sociedade Brasileira de Pediatria
2019
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oai:scielo:S0021-755720190001000872019-02-05Decreased health-related quality of life in children and adolescents with autoimmune hepatitisBozzini,Ana BeatrizNeder,LucianaSilva,Clovis A.Porta,Gilda Quality of life Autoimmune hepatitis Childhood Adolescence Chronic disease PedsQL 4.0 Abstract Objective: The objective of this study was to evaluate the health-related quality of life in children and adolescents with autoimmune hepatitis. Methods: A cross-sectional assessment with the Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0) was completed for 80 patients with autoimmune hepatitis and 45 healthy controls. Demographic data, prednisone dose, disease remission state, disease severity, and abdominal pain were also evaluated. Results: Based on the child self-reports, physical, emotional, school, and total scores were significantly lower in autoimmune hepatitis patients when compared with controls (p < 0.05). Based on the parental reports, only the physical and total scores were significantly lower in autoimmune hepatitis patients versus controls (p < 0.05). Further analysis in autoimmune hepatitis patients with abdominal pain in the last month revealed significantly lower physical, social, and total median scores (p < 0.05). No differences were observed based on disease remission state or disease severity (p > 0.05). Autoimmune hepatitis patients who received a prednisone dose below 0.16 mg/kg/day at the time of the interview showed significantly higher physical scores than those who received a dose similar to or above 0.16 mg/kg/day (87.5 [50–100] vs. 75 [15.63–100], p = 0.006). Conclusions: Reduced scores in the physical, emotional, and school domains were observed in pediatric autoimmune hepatitis patients compared to control patients. Abdominal pain and corticosteroid dose negatively influenced the health-related quality of life in children and adolescents with autoimmune hepatitis.info:eu-repo/semantics/openAccessSociedade Brasileira de PediatriaJornal de Pediatria v.95 n.1 20192019-02-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000100087en10.1016/j.jped.2017.10.013 |
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Bozzini,Ana Beatriz Neder,Luciana Silva,Clovis A. Porta,Gilda |
| spellingShingle |
Bozzini,Ana Beatriz Neder,Luciana Silva,Clovis A. Porta,Gilda Decreased health-related quality of life in children and adolescents with autoimmune hepatitis |
| author_facet |
Bozzini,Ana Beatriz Neder,Luciana Silva,Clovis A. Porta,Gilda |
| author_sort |
Bozzini,Ana Beatriz |
| title |
Decreased health-related quality of life in children and adolescents with autoimmune hepatitis |
| title_short |
Decreased health-related quality of life in children and adolescents with autoimmune hepatitis |
| title_full |
Decreased health-related quality of life in children and adolescents with autoimmune hepatitis |
| title_fullStr |
Decreased health-related quality of life in children and adolescents with autoimmune hepatitis |
| title_full_unstemmed |
Decreased health-related quality of life in children and adolescents with autoimmune hepatitis |
| title_sort |
decreased health-related quality of life in children and adolescents with autoimmune hepatitis |
| description |
Abstract Objective: The objective of this study was to evaluate the health-related quality of life in children and adolescents with autoimmune hepatitis. Methods: A cross-sectional assessment with the Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0) was completed for 80 patients with autoimmune hepatitis and 45 healthy controls. Demographic data, prednisone dose, disease remission state, disease severity, and abdominal pain were also evaluated. Results: Based on the child self-reports, physical, emotional, school, and total scores were significantly lower in autoimmune hepatitis patients when compared with controls (p < 0.05). Based on the parental reports, only the physical and total scores were significantly lower in autoimmune hepatitis patients versus controls (p < 0.05). Further analysis in autoimmune hepatitis patients with abdominal pain in the last month revealed significantly lower physical, social, and total median scores (p < 0.05). No differences were observed based on disease remission state or disease severity (p > 0.05). Autoimmune hepatitis patients who received a prednisone dose below 0.16 mg/kg/day at the time of the interview showed significantly higher physical scores than those who received a dose similar to or above 0.16 mg/kg/day (87.5 [50–100] vs. 75 [15.63–100], p = 0.006). Conclusions: Reduced scores in the physical, emotional, and school domains were observed in pediatric autoimmune hepatitis patients compared to control patients. Abdominal pain and corticosteroid dose negatively influenced the health-related quality of life in children and adolescents with autoimmune hepatitis. |
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Sociedade Brasileira de Pediatria |
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2019 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000100087 |
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