Cerebral hemodynamic and metabolic changes in fulminant hepatic failure

Cerebral hemodynamic and metabolic changes in fulminant hepatic failure

ABSTRACT Intracranial hypertension and brain swelling are a major cause of morbidity and mortality of patients suffering from fulminant hepatic failure (FHF). The pathogenesis of these complications has been investigated in man, in experimental models and in isolated cell systems. Currently, the mechanism underlying cerebral edema and intracranial hypertension in the presence of FHF is multi-factorial in etiology and only partially understood. The aim of this paper is to review the pathophysiology of cerebral hemodynamic and metabolism changes in FHF in order to improve understanding of intracranial dynamics complication in FHF.

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Bibliographic Details
Main Authors: Paschoal Junior,Fernando Mendes, Nogueira,Ricardo de Carvalho, Oliveira,Marcelo de Lima, Paschoal,Eric Homero Albuquerque, Teixeira,Manoel Jacobsen, D’Albuquerque,Luiz Augusto Carneiro, Bor-Seng-Shu,Edson
Format: Digital revista
Language:English
Published: Academia Brasileira de Neurologia - ABNEURO 2017
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000700470
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Summary:ABSTRACT Intracranial hypertension and brain swelling are a major cause of morbidity and mortality of patients suffering from fulminant hepatic failure (FHF). The pathogenesis of these complications has been investigated in man, in experimental models and in isolated cell systems. Currently, the mechanism underlying cerebral edema and intracranial hypertension in the presence of FHF is multi-factorial in etiology and only partially understood. The aim of this paper is to review the pathophysiology of cerebral hemodynamic and metabolism changes in FHF in order to improve understanding of intracranial dynamics complication in FHF.

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