Limitations in differentiating vascular dementia from Alzheimer's disease with brief cognitive tests
OBJECTIVE: To investigate the diagnostic value of brief cognitive tests in differentiating vascular dementia (VaD) from Alzheimer's disease (AD). METHOD: Fifteen patients with mild VaD, 15 patients with mild probable AD and 30 healthy controls, matched for age, education and dementia severity, were submitted to the following cognitive tests: clock drawing (free drawing and copy), category and letter fluency, delayed recall test of figures and the EXIT 25 battery. RESULTS: VaD patients performed worse than AD patients in category fluency (p=0.014), letter fluency (p=0.043) and CLOX 2 (p=0.023), while AD cases performed worse than VaD patients in delayed recall (p=0.013). However, ROC curves for these tests displayed low sensitivity and specificity for the differential diagnosis between VaD and AD. CONCLUSION: Although the performance of VaD and AD patients was significantly different in some cognitive tests, the value of such instruments in differentiating VaD from AD proved to be very limited.
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Academia Brasileira de Neurologia - ABNEURO
2010
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oai:scielo:S0004-282X20100002000062010-04-28Limitations in differentiating vascular dementia from Alzheimer's disease with brief cognitive testsMatioli,Maria Niures P.S.Caramelli,Paulo Alzheimer's disease vascular dementia clock drawing test delayed recall diagnosis EXIT25 neuropsychological tests verbal fluency OBJECTIVE: To investigate the diagnostic value of brief cognitive tests in differentiating vascular dementia (VaD) from Alzheimer's disease (AD). METHOD: Fifteen patients with mild VaD, 15 patients with mild probable AD and 30 healthy controls, matched for age, education and dementia severity, were submitted to the following cognitive tests: clock drawing (free drawing and copy), category and letter fluency, delayed recall test of figures and the EXIT 25 battery. RESULTS: VaD patients performed worse than AD patients in category fluency (p=0.014), letter fluency (p=0.043) and CLOX 2 (p=0.023), while AD cases performed worse than VaD patients in delayed recall (p=0.013). However, ROC curves for these tests displayed low sensitivity and specificity for the differential diagnosis between VaD and AD. CONCLUSION: Although the performance of VaD and AD patients was significantly different in some cognitive tests, the value of such instruments in differentiating VaD from AD proved to be very limited.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.68 n.2 20102010-04-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000200006en10.1590/S0004-282X2010000200006 |
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Matioli,Maria Niures P.S. Caramelli,Paulo |
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Matioli,Maria Niures P.S. Caramelli,Paulo Limitations in differentiating vascular dementia from Alzheimer's disease with brief cognitive tests |
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Matioli,Maria Niures P.S. Caramelli,Paulo |
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Matioli,Maria Niures P.S. |
title |
Limitations in differentiating vascular dementia from Alzheimer's disease with brief cognitive tests |
title_short |
Limitations in differentiating vascular dementia from Alzheimer's disease with brief cognitive tests |
title_full |
Limitations in differentiating vascular dementia from Alzheimer's disease with brief cognitive tests |
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Limitations in differentiating vascular dementia from Alzheimer's disease with brief cognitive tests |
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Limitations in differentiating vascular dementia from Alzheimer's disease with brief cognitive tests |
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limitations in differentiating vascular dementia from alzheimer's disease with brief cognitive tests |
description |
OBJECTIVE: To investigate the diagnostic value of brief cognitive tests in differentiating vascular dementia (VaD) from Alzheimer's disease (AD). METHOD: Fifteen patients with mild VaD, 15 patients with mild probable AD and 30 healthy controls, matched for age, education and dementia severity, were submitted to the following cognitive tests: clock drawing (free drawing and copy), category and letter fluency, delayed recall test of figures and the EXIT 25 battery. RESULTS: VaD patients performed worse than AD patients in category fluency (p=0.014), letter fluency (p=0.043) and CLOX 2 (p=0.023), while AD cases performed worse than VaD patients in delayed recall (p=0.013). However, ROC curves for these tests displayed low sensitivity and specificity for the differential diagnosis between VaD and AD. CONCLUSION: Although the performance of VaD and AD patients was significantly different in some cognitive tests, the value of such instruments in differentiating VaD from AD proved to be very limited. |
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Academia Brasileira de Neurologia - ABNEURO |
publishDate |
2010 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000200006 |
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AT matiolimarianiuresps limitationsindifferentiatingvasculardementiafromalzheimersdiseasewithbriefcognitivetests AT caramellipaulo limitationsindifferentiatingvasculardementiafromalzheimersdiseasewithbriefcognitivetests |
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