Selective hypothermia: an experimental study on traumatic brain injury in rats
OBJECTIVE: To evaluate the efficiency of selective hypothermia in the treatment of the traumatic brain injury in rats. METHOD: After the trauma produced for the model of cortical impact, a small craniectomy in the right frontoparietal region was carried through; after the procedure the animals had been divided in two groups of 15 each. Group A, without treatment with hypothermia (control group) and group B, treated with selective hypothermia for a period to 5 to 6 hours. After this time all the animals were sacrificed, their brains had been removed and histopathological analysis was carried through. RESULTS: Comparison between both groups was done using the counting of neurons injured for field. Counting in the control group n=15 had an average of 70.80 neurons injured for field against an average of 21.33 neurons injured for field in group B (submitted to the treatment with hypothermia), with n=15 also. The difference was statiscally significant. CONCLUSION: Based in the quantification of the neurons injured for field, the effectiveness of the treatment with selective hypothermia was demonstrated.
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Academia Brasileira de Neurologia - ABNEURO
2008
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oai:scielo:S0004-282X20080003000212008-09-29Selective hypothermia: an experimental study on traumatic brain injury in ratsDvilevicius,Amylcar EdemilsonPrandini,Mirto Nelso selective hypothermia hypothermia neuroprotection traumatic brain injury OBJECTIVE: To evaluate the efficiency of selective hypothermia in the treatment of the traumatic brain injury in rats. METHOD: After the trauma produced for the model of cortical impact, a small craniectomy in the right frontoparietal region was carried through; after the procedure the animals had been divided in two groups of 15 each. Group A, without treatment with hypothermia (control group) and group B, treated with selective hypothermia for a period to 5 to 6 hours. After this time all the animals were sacrificed, their brains had been removed and histopathological analysis was carried through. RESULTS: Comparison between both groups was done using the counting of neurons injured for field. Counting in the control group n=15 had an average of 70.80 neurons injured for field against an average of 21.33 neurons injured for field in group B (submitted to the treatment with hypothermia), with n=15 also. The difference was statiscally significant. CONCLUSION: Based in the quantification of the neurons injured for field, the effectiveness of the treatment with selective hypothermia was demonstrated.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.66 n.2b 20082008-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000300021en10.1590/S0004-282X2008000300021 |
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Dvilevicius,Amylcar Edemilson Prandini,Mirto Nelso |
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Dvilevicius,Amylcar Edemilson Prandini,Mirto Nelso Selective hypothermia: an experimental study on traumatic brain injury in rats |
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Dvilevicius,Amylcar Edemilson Prandini,Mirto Nelso |
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Dvilevicius,Amylcar Edemilson |
title |
Selective hypothermia: an experimental study on traumatic brain injury in rats |
title_short |
Selective hypothermia: an experimental study on traumatic brain injury in rats |
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Selective hypothermia: an experimental study on traumatic brain injury in rats |
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Selective hypothermia: an experimental study on traumatic brain injury in rats |
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Selective hypothermia: an experimental study on traumatic brain injury in rats |
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selective hypothermia: an experimental study on traumatic brain injury in rats |
description |
OBJECTIVE: To evaluate the efficiency of selective hypothermia in the treatment of the traumatic brain injury in rats. METHOD: After the trauma produced for the model of cortical impact, a small craniectomy in the right frontoparietal region was carried through; after the procedure the animals had been divided in two groups of 15 each. Group A, without treatment with hypothermia (control group) and group B, treated with selective hypothermia for a period to 5 to 6 hours. After this time all the animals were sacrificed, their brains had been removed and histopathological analysis was carried through. RESULTS: Comparison between both groups was done using the counting of neurons injured for field. Counting in the control group n=15 had an average of 70.80 neurons injured for field against an average of 21.33 neurons injured for field in group B (submitted to the treatment with hypothermia), with n=15 also. The difference was statiscally significant. CONCLUSION: Based in the quantification of the neurons injured for field, the effectiveness of the treatment with selective hypothermia was demonstrated. |
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Academia Brasileira de Neurologia - ABNEURO |
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2008 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000300021 |
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AT dvileviciusamylcaredemilson selectivehypothermiaanexperimentalstudyontraumaticbraininjuryinrats AT prandinimirtonelso selectivehypothermiaanexperimentalstudyontraumaticbraininjuryinrats |
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