Immunohistochemical expression of markers Ki-67, neun, synaptophysin, p53 and HER2 in medulloblastoma and its correlation with clinicopathological parameters
Medulloblastoma (MB) is the most common malignant brain tumor in childhood. The alterations found include: presence of oncoproteins p53 and HER2, elevated mitotic index, and presence of neuronal differentiation. The aim of this study was to determine the immunohistochemical expression of markers Ki-67, NeuN, synaptophysin, HER2 and p53 in 40 MB samples and their correlation with clinicopathologic parameters and survival. In 29 patients (72.5%), >20% of cells were positive for Ki-67. Males showed greater ki-67 expression (p=0.02) and smaller survival rates (p=0.002). NeuN and synaptophysin were negative in 16 (40%) and 8 (20%) cases, respectively. P53 was positive in 18 (45%) cases, with 11 (61%) weakly positive and 7 (39%) strongly positive. HER2 was positive in 23 (57.5%) of the samples and did not show statistical association with survival (p=0.07).
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Academia Brasileira de Neurologia - ABNEURO
2008
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oai:scielo:S0004-282X20080003000202008-09-29Immunohistochemical expression of markers Ki-67, neun, synaptophysin, p53 and HER2 in medulloblastoma and its correlation with clinicopathological parametersMeurer,Rosalva TherezaMartins,Daniele TondoloHilbig,ArleteRibeiro,Marlise de CastroRoehe,Adriana VialBarbosa-Coutinho,Ligia MariaFernandes,Marilda da Cruz medulloblastoma immunohistochemistry Ki-67 NeuN synaptophysin HER2 p53 survival analysis Medulloblastoma (MB) is the most common malignant brain tumor in childhood. The alterations found include: presence of oncoproteins p53 and HER2, elevated mitotic index, and presence of neuronal differentiation. The aim of this study was to determine the immunohistochemical expression of markers Ki-67, NeuN, synaptophysin, HER2 and p53 in 40 MB samples and their correlation with clinicopathologic parameters and survival. In 29 patients (72.5%), >20% of cells were positive for Ki-67. Males showed greater ki-67 expression (p=0.02) and smaller survival rates (p=0.002). NeuN and synaptophysin were negative in 16 (40%) and 8 (20%) cases, respectively. P53 was positive in 18 (45%) cases, with 11 (61%) weakly positive and 7 (39%) strongly positive. HER2 was positive in 23 (57.5%) of the samples and did not show statistical association with survival (p=0.07).info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.66 n.2b 20082008-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000300020en10.1590/S0004-282X2008000300020 |
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Meurer,Rosalva Thereza Martins,Daniele Tondolo Hilbig,Arlete Ribeiro,Marlise de Castro Roehe,Adriana Vial Barbosa-Coutinho,Ligia Maria Fernandes,Marilda da Cruz |
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Meurer,Rosalva Thereza Martins,Daniele Tondolo Hilbig,Arlete Ribeiro,Marlise de Castro Roehe,Adriana Vial Barbosa-Coutinho,Ligia Maria Fernandes,Marilda da Cruz Immunohistochemical expression of markers Ki-67, neun, synaptophysin, p53 and HER2 in medulloblastoma and its correlation with clinicopathological parameters |
author_facet |
Meurer,Rosalva Thereza Martins,Daniele Tondolo Hilbig,Arlete Ribeiro,Marlise de Castro Roehe,Adriana Vial Barbosa-Coutinho,Ligia Maria Fernandes,Marilda da Cruz |
author_sort |
Meurer,Rosalva Thereza |
title |
Immunohistochemical expression of markers Ki-67, neun, synaptophysin, p53 and HER2 in medulloblastoma and its correlation with clinicopathological parameters |
title_short |
Immunohistochemical expression of markers Ki-67, neun, synaptophysin, p53 and HER2 in medulloblastoma and its correlation with clinicopathological parameters |
title_full |
Immunohistochemical expression of markers Ki-67, neun, synaptophysin, p53 and HER2 in medulloblastoma and its correlation with clinicopathological parameters |
title_fullStr |
Immunohistochemical expression of markers Ki-67, neun, synaptophysin, p53 and HER2 in medulloblastoma and its correlation with clinicopathological parameters |
title_full_unstemmed |
Immunohistochemical expression of markers Ki-67, neun, synaptophysin, p53 and HER2 in medulloblastoma and its correlation with clinicopathological parameters |
title_sort |
immunohistochemical expression of markers ki-67, neun, synaptophysin, p53 and her2 in medulloblastoma and its correlation with clinicopathological parameters |
description |
Medulloblastoma (MB) is the most common malignant brain tumor in childhood. The alterations found include: presence of oncoproteins p53 and HER2, elevated mitotic index, and presence of neuronal differentiation. The aim of this study was to determine the immunohistochemical expression of markers Ki-67, NeuN, synaptophysin, HER2 and p53 in 40 MB samples and their correlation with clinicopathologic parameters and survival. In 29 patients (72.5%), >20% of cells were positive for Ki-67. Males showed greater ki-67 expression (p=0.02) and smaller survival rates (p=0.002). NeuN and synaptophysin were negative in 16 (40%) and 8 (20%) cases, respectively. P53 was positive in 18 (45%) cases, with 11 (61%) weakly positive and 7 (39%) strongly positive. HER2 was positive in 23 (57.5%) of the samples and did not show statistical association with survival (p=0.07). |
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Academia Brasileira de Neurologia - ABNEURO |
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2008 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000300020 |
work_keys_str_mv |
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