Peripheral neuropathy in hypereosinophilic syndrome with vasculitis

A 53-year-old woman with non-productive cough of unexplained aetiology for two years, developed a sub-acute symmetrical polyneuropathy involving all four limbs, accompanied by fever, cutaneous rash and myalgia in lower limbs. Laboratory studies revealed a leukocytosis with 70% eosinophils and excluded any cause for the hypereosinophilia. An echocardiogram showed increase in thickness of the atrial septum. Motor and sensory conduction velocity were reduced in ulnar and median nerve, and unrecordable in peroneal and tibial nerves. A sural nerve biopsy showed an axonal degeneration involving myelinated and unmyelinated fibers as well as a vasculitis with fibrinoid necrosis and perivascular infiltration of eosinophils. There was considerable clinical and laboratorial improvement with the use of steroids. The differential diagnosis between idiopathic hypereosinophilic syndrome and other disorders known to course with vasculitis and hypereosinophilia is discussed.

Bibliographic Details

Main Authors:	Nascimento,Osvaldo, Freitas,Marcos de, Chimelli,Leila, Scaravilli,Francesco
Format:	Digital revista
Language:	English
Published:	Academia Brasileira de Neurologia - ABNEURO 1991
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1991000400015
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