Chemical Composition of Argentinean Propolis Collected in Extreme Regions and its Relation with Antimicrobial and Antioxidant Activities

This paper reveals, for the first time, the functional properties of propolis from an extreme region of Argentine (El Rincón, Province of Catamarca, Argentina), as well as the isolation and identification of bioactive compounds. The antioxidant activity was determined by the ABTS method and β-carotene bleaching. The antibacterial activity was determined on methicillin resistant Staphylococcus aureus (MRSA) by the microdilution method and bioautographic assays. Twelve compounds were isolated and identified by NMR spectroscopy. The main bioactive compounds were 2′,4′-dihydroxy-3′-methoxychalcone (3), 2′,4′-dihydroxychalcone (9), 2′,4′,4-trihydroxy-6′- methoxychalcone (8), 5-hydroxy-4′,7-dimethoxyflavone (4), 4′,5-dihydroxy-3,7,8-trimethoxyflavone (10) and 7-hydroxy- 5,8-dimethoxyflavone (11). All compounds were active against clinical isolates (MIC50 10 μg/ mL) and displayed antioxidant activity (SC50 values of 20 μg/mL). The MIC and SC50 values of the isolated compounds were lower than those obtained with crude propolis extracts, chloroform sub-extracts and isolated fractions.

Bibliographic Details

Main Authors:	Vera, Nancy Roxana, Solórzano, Eliana, Ordóñez, Roxana Mabel, Maldonado, Luis Maria, Bedascarrasbure, Enrique Luciano, Isla, María Inés
Format:	info:ar-repo/semantics/artículo biblioteca
Language:	eng
Published:	Sage Publishing 2011-06
Subjects:	Propóleos, Composición Quimica, Propiedades Antimicrobianas, Propiedades Antioxidantes, Argentina, Propolis, Chemical Composition, Antimicrobial Properties, Antioxidant Properties, cientifico,
Online Access:	http://hdl.handle.net/20.500.12123/12357 https://journals.sagepub.com/doi/abs/10.1177/1934578X1100600618 https://doi.org/10.1177/1934578X1100600618
Tags:	Add Tag No Tags, Be the first to tag this record!