Continued Circulation of Tick-Borne Encephalitis Virus Variants and Detection of Novel Transmission Foci, the Netherlands

Tick-borne encephalitis virus (TBEV) is an emerging pathogen that was first detected in ticks and humans in the Netherlands in 2015 (ticks) and 2016 (humans). To learn more about its distribution and prevalence in the Netherlands, we conducted large-scale surveillance in ticks and rodents during August 2018–September 2020. We tested 320 wild rodents and >46,000 ticks from 48 locations considered to be at high risk for TBEV circulation. We found TBEV RNA in 3 rodents (0.9%) and 7 tick pools (minimum infection rate 0.02%) from 5 geographically distinct foci. Phylogenetic analyses indicated that 3 different variants of the TBEV-Eu subtype circulate in the Netherlands, suggesting multiple independent introductions. Combined with recent human cases outside known TBEV hotspots, our data demonstrate that the distribution of TBEV in the Netherlands is more widespread than previously thought.

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Main Authors: Esser, Helen J., Lim, Stephanie M., de Vries, Ankje, Sprong, Hein, Dekker, Dinant J., Pascoe, Emily L., Bakker, Julian W., Suin, Vanessa, Franz, Eelco, Martina, Byron E.E., Koenraadt, Constantianus J.M.
Format: Article/Letter to editor biblioteca
Language:English
Subjects:Life Science,
Online Access:https://research.wur.nl/en/publications/continued-circulation-of-tick-borne-encephalitis-virus-variants-a
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spelling dig-wur-nl-wurpubs-6075122025-01-14 Esser, Helen J. Lim, Stephanie M. de Vries, Ankje Sprong, Hein Dekker, Dinant J. Pascoe, Emily L. Bakker, Julian W. Suin, Vanessa Franz, Eelco Martina, Byron E.E. Koenraadt, Constantianus J.M. Article/Letter to editor Emerging Infectious Diseases 28 (2022) 12 ISSN: 1080-6040 Continued Circulation of Tick-Borne Encephalitis Virus Variants and Detection of Novel Transmission Foci, the Netherlands 2022 Tick-borne encephalitis virus (TBEV) is an emerging pathogen that was first detected in ticks and humans in the Netherlands in 2015 (ticks) and 2016 (humans). To learn more about its distribution and prevalence in the Netherlands, we conducted large-scale surveillance in ticks and rodents during August 2018–September 2020. We tested 320 wild rodents and >46,000 ticks from 48 locations considered to be at high risk for TBEV circulation. We found TBEV RNA in 3 rodents (0.9%) and 7 tick pools (minimum infection rate 0.02%) from 5 geographically distinct foci. Phylogenetic analyses indicated that 3 different variants of the TBEV-Eu subtype circulate in the Netherlands, suggesting multiple independent introductions. Combined with recent human cases outside known TBEV hotspots, our data demonstrate that the distribution of TBEV in the Netherlands is more widespread than previously thought. en application/pdf https://research.wur.nl/en/publications/continued-circulation-of-tick-borne-encephalitis-virus-variants-a 10.3201/eid2812.220552 https://edepot.wur.nl/584432 Life Science (c) publisher Wageningen University & Research
institution WUR NL
collection DSpace
country Países bajos
countrycode NL
component Bibliográfico
access En linea
databasecode dig-wur-nl
tag biblioteca
region Europa del Oeste
libraryname WUR Library Netherlands
language English
topic Life Science
Life Science
spellingShingle Life Science
Life Science
Esser, Helen J.
Lim, Stephanie M.
de Vries, Ankje
Sprong, Hein
Dekker, Dinant J.
Pascoe, Emily L.
Bakker, Julian W.
Suin, Vanessa
Franz, Eelco
Martina, Byron E.E.
Koenraadt, Constantianus J.M.
Continued Circulation of Tick-Borne Encephalitis Virus Variants and Detection of Novel Transmission Foci, the Netherlands
description Tick-borne encephalitis virus (TBEV) is an emerging pathogen that was first detected in ticks and humans in the Netherlands in 2015 (ticks) and 2016 (humans). To learn more about its distribution and prevalence in the Netherlands, we conducted large-scale surveillance in ticks and rodents during August 2018–September 2020. We tested 320 wild rodents and >46,000 ticks from 48 locations considered to be at high risk for TBEV circulation. We found TBEV RNA in 3 rodents (0.9%) and 7 tick pools (minimum infection rate 0.02%) from 5 geographically distinct foci. Phylogenetic analyses indicated that 3 different variants of the TBEV-Eu subtype circulate in the Netherlands, suggesting multiple independent introductions. Combined with recent human cases outside known TBEV hotspots, our data demonstrate that the distribution of TBEV in the Netherlands is more widespread than previously thought.
format Article/Letter to editor
topic_facet Life Science
author Esser, Helen J.
Lim, Stephanie M.
de Vries, Ankje
Sprong, Hein
Dekker, Dinant J.
Pascoe, Emily L.
Bakker, Julian W.
Suin, Vanessa
Franz, Eelco
Martina, Byron E.E.
Koenraadt, Constantianus J.M.
author_facet Esser, Helen J.
Lim, Stephanie M.
de Vries, Ankje
Sprong, Hein
Dekker, Dinant J.
Pascoe, Emily L.
Bakker, Julian W.
Suin, Vanessa
Franz, Eelco
Martina, Byron E.E.
Koenraadt, Constantianus J.M.
author_sort Esser, Helen J.
title Continued Circulation of Tick-Borne Encephalitis Virus Variants and Detection of Novel Transmission Foci, the Netherlands
title_short Continued Circulation of Tick-Borne Encephalitis Virus Variants and Detection of Novel Transmission Foci, the Netherlands
title_full Continued Circulation of Tick-Borne Encephalitis Virus Variants and Detection of Novel Transmission Foci, the Netherlands
title_fullStr Continued Circulation of Tick-Borne Encephalitis Virus Variants and Detection of Novel Transmission Foci, the Netherlands
title_full_unstemmed Continued Circulation of Tick-Borne Encephalitis Virus Variants and Detection of Novel Transmission Foci, the Netherlands
title_sort continued circulation of tick-borne encephalitis virus variants and detection of novel transmission foci, the netherlands
url https://research.wur.nl/en/publications/continued-circulation-of-tick-borne-encephalitis-virus-variants-a
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