Continued Circulation of Tick-Borne Encephalitis Virus Variants and Detection of Novel Transmission Foci, the Netherlands
Tick-borne encephalitis virus (TBEV) is an emerging pathogen that was first detected in ticks and humans in the Netherlands in 2015 (ticks) and 2016 (humans). To learn more about its distribution and prevalence in the Netherlands, we conducted large-scale surveillance in ticks and rodents during August 2018–September 2020. We tested 320 wild rodents and >46,000 ticks from 48 locations considered to be at high risk for TBEV circulation. We found TBEV RNA in 3 rodents (0.9%) and 7 tick pools (minimum infection rate 0.02%) from 5 geographically distinct foci. Phylogenetic analyses indicated that 3 different variants of the TBEV-Eu subtype circulate in the Netherlands, suggesting multiple independent introductions. Combined with recent human cases outside known TBEV hotspots, our data demonstrate that the distribution of TBEV in the Netherlands is more widespread than previously thought.
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dig-wur-nl-wurpubs-6075122025-01-14 Esser, Helen J. Lim, Stephanie M. de Vries, Ankje Sprong, Hein Dekker, Dinant J. Pascoe, Emily L. Bakker, Julian W. Suin, Vanessa Franz, Eelco Martina, Byron E.E. Koenraadt, Constantianus J.M. Article/Letter to editor Emerging Infectious Diseases 28 (2022) 12 ISSN: 1080-6040 Continued Circulation of Tick-Borne Encephalitis Virus Variants and Detection of Novel Transmission Foci, the Netherlands 2022 Tick-borne encephalitis virus (TBEV) is an emerging pathogen that was first detected in ticks and humans in the Netherlands in 2015 (ticks) and 2016 (humans). To learn more about its distribution and prevalence in the Netherlands, we conducted large-scale surveillance in ticks and rodents during August 2018–September 2020. We tested 320 wild rodents and >46,000 ticks from 48 locations considered to be at high risk for TBEV circulation. We found TBEV RNA in 3 rodents (0.9%) and 7 tick pools (minimum infection rate 0.02%) from 5 geographically distinct foci. Phylogenetic analyses indicated that 3 different variants of the TBEV-Eu subtype circulate in the Netherlands, suggesting multiple independent introductions. Combined with recent human cases outside known TBEV hotspots, our data demonstrate that the distribution of TBEV in the Netherlands is more widespread than previously thought. en application/pdf https://research.wur.nl/en/publications/continued-circulation-of-tick-borne-encephalitis-virus-variants-a 10.3201/eid2812.220552 https://edepot.wur.nl/584432 Life Science (c) publisher Wageningen University & Research |
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Life Science Life Science Esser, Helen J. Lim, Stephanie M. de Vries, Ankje Sprong, Hein Dekker, Dinant J. Pascoe, Emily L. Bakker, Julian W. Suin, Vanessa Franz, Eelco Martina, Byron E.E. Koenraadt, Constantianus J.M. Continued Circulation of Tick-Borne Encephalitis Virus Variants and Detection of Novel Transmission Foci, the Netherlands |
description |
Tick-borne encephalitis virus (TBEV) is an emerging pathogen that was first detected in ticks and humans in the Netherlands in 2015 (ticks) and 2016 (humans). To learn more about its distribution and prevalence in the Netherlands, we conducted large-scale surveillance in ticks and rodents during August 2018–September 2020. We tested 320 wild rodents and >46,000 ticks from 48 locations considered to be at high risk for TBEV circulation. We found TBEV RNA in 3 rodents (0.9%) and 7 tick pools (minimum infection rate 0.02%) from 5 geographically distinct foci. Phylogenetic analyses indicated that 3 different variants of the TBEV-Eu subtype circulate in the Netherlands, suggesting multiple independent introductions. Combined with recent human cases outside known TBEV hotspots, our data demonstrate that the distribution of TBEV in the Netherlands is more widespread than previously thought. |
format |
Article/Letter to editor |
topic_facet |
Life Science |
author |
Esser, Helen J. Lim, Stephanie M. de Vries, Ankje Sprong, Hein Dekker, Dinant J. Pascoe, Emily L. Bakker, Julian W. Suin, Vanessa Franz, Eelco Martina, Byron E.E. Koenraadt, Constantianus J.M. |
author_facet |
Esser, Helen J. Lim, Stephanie M. de Vries, Ankje Sprong, Hein Dekker, Dinant J. Pascoe, Emily L. Bakker, Julian W. Suin, Vanessa Franz, Eelco Martina, Byron E.E. Koenraadt, Constantianus J.M. |
author_sort |
Esser, Helen J. |
title |
Continued Circulation of Tick-Borne Encephalitis Virus Variants and Detection of Novel Transmission Foci, the Netherlands |
title_short |
Continued Circulation of Tick-Borne Encephalitis Virus Variants and Detection of Novel Transmission Foci, the Netherlands |
title_full |
Continued Circulation of Tick-Borne Encephalitis Virus Variants and Detection of Novel Transmission Foci, the Netherlands |
title_fullStr |
Continued Circulation of Tick-Borne Encephalitis Virus Variants and Detection of Novel Transmission Foci, the Netherlands |
title_full_unstemmed |
Continued Circulation of Tick-Borne Encephalitis Virus Variants and Detection of Novel Transmission Foci, the Netherlands |
title_sort |
continued circulation of tick-borne encephalitis virus variants and detection of novel transmission foci, the netherlands |
url |
https://research.wur.nl/en/publications/continued-circulation-of-tick-borne-encephalitis-virus-variants-a |
work_keys_str_mv |
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1822264956613033984 |