The Effect of Partly Replacing Vegetable Fat with Bovine Milk Fat in Infant Formula on Postprandial Lipid and Energy Metabolism : A Proof-of-principle Study in Healthy Young Male Adults
Scope: Infant formula (IF) uses besides vegetable fats also bovine milk fat, which differs in triacylglycerol (TAG) structure. Furthermore, it differs in fatty acid (FA) composition. Whether changing fat source in IF affects postprandial energy metabolism, lipemic response, and blood lipid profile is unknown. Methods and Results: A proof-of-principle study, with a randomized controlled double-blind cross-over design, is conducted. Twenty healthy male adults consumed drinks with either 100% vegetable fat (VEG) or 67% bovine milk fat and 33% vegetable fat (BOV), on 2 separate days. For a detailed insight in the postprandial responses, indirect calorimetry is performed continuously, and venous blood samples are taken every 30 min, until 5 h postprandially. No differences in postprandial energy metabolism, serum lipids, lipoprotein, or chylomicron concentrations are observed between drinks. After consumption of VEG-drink, C18:2n-6 in serum increased. Observed differences in chylomicron FA profile reflect differences in initial FA profile of test drinks. Serum ketone bodies concentrations increase following consumption of BOV-drink. Conclusions: The use of bovine milk fat in IF does neither affect postprandial energy metabolism nor lipemic response in healthy adults, but alters postprandial FA profiles and ketone metabolism. Whether the exact same effects occur in infants requires experimental verification.
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| Language: | English |
| Subjects: | bovine milk fat, chylomicrons, infant formula, lipidomics, metabolism, |
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dig-wur-nl-wurpubs-5820572024-12-04 Hageman, Jeske H.J. Erdõs, Balázs Keijer, Jaap Adriaens, Michiel de Wit, Britt Stañková, Barbora Tvrzická, Eva Arts, Ilja C.W. Nieuwenhuizen, Arie G. Article/Letter to editor Molecular Nutrition and Food Research 65 (2021) 9 ISSN: 1613-4125 The Effect of Partly Replacing Vegetable Fat with Bovine Milk Fat in Infant Formula on Postprandial Lipid and Energy Metabolism : A Proof-of-principle Study in Healthy Young Male Adults 2021 Scope: Infant formula (IF) uses besides vegetable fats also bovine milk fat, which differs in triacylglycerol (TAG) structure. Furthermore, it differs in fatty acid (FA) composition. Whether changing fat source in IF affects postprandial energy metabolism, lipemic response, and blood lipid profile is unknown. Methods and Results: A proof-of-principle study, with a randomized controlled double-blind cross-over design, is conducted. Twenty healthy male adults consumed drinks with either 100% vegetable fat (VEG) or 67% bovine milk fat and 33% vegetable fat (BOV), on 2 separate days. For a detailed insight in the postprandial responses, indirect calorimetry is performed continuously, and venous blood samples are taken every 30 min, until 5 h postprandially. No differences in postprandial energy metabolism, serum lipids, lipoprotein, or chylomicron concentrations are observed between drinks. After consumption of VEG-drink, C18:2n-6 in serum increased. Observed differences in chylomicron FA profile reflect differences in initial FA profile of test drinks. Serum ketone bodies concentrations increase following consumption of BOV-drink. Conclusions: The use of bovine milk fat in IF does neither affect postprandial energy metabolism nor lipemic response in healthy adults, but alters postprandial FA profiles and ketone metabolism. Whether the exact same effects occur in infants requires experimental verification. en application/pdf https://research.wur.nl/en/publications/the-effect-of-partly-replacing-vegetable-fat-with-bovine-milk-fat 10.1002/mnfr.202000848 https://edepot.wur.nl/546268 bovine milk fat chylomicrons infant formula lipidomics metabolism https://creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/ Wageningen University & Research |
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bovine milk fat chylomicrons infant formula lipidomics metabolism bovine milk fat chylomicrons infant formula lipidomics metabolism |
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bovine milk fat chylomicrons infant formula lipidomics metabolism bovine milk fat chylomicrons infant formula lipidomics metabolism Hageman, Jeske H.J. Erdõs, Balázs Keijer, Jaap Adriaens, Michiel de Wit, Britt Stañková, Barbora Tvrzická, Eva Arts, Ilja C.W. Nieuwenhuizen, Arie G. The Effect of Partly Replacing Vegetable Fat with Bovine Milk Fat in Infant Formula on Postprandial Lipid and Energy Metabolism : A Proof-of-principle Study in Healthy Young Male Adults |
| description |
Scope: Infant formula (IF) uses besides vegetable fats also bovine milk fat, which differs in triacylglycerol (TAG) structure. Furthermore, it differs in fatty acid (FA) composition. Whether changing fat source in IF affects postprandial energy metabolism, lipemic response, and blood lipid profile is unknown. Methods and Results: A proof-of-principle study, with a randomized controlled double-blind cross-over design, is conducted. Twenty healthy male adults consumed drinks with either 100% vegetable fat (VEG) or 67% bovine milk fat and 33% vegetable fat (BOV), on 2 separate days. For a detailed insight in the postprandial responses, indirect calorimetry is performed continuously, and venous blood samples are taken every 30 min, until 5 h postprandially. No differences in postprandial energy metabolism, serum lipids, lipoprotein, or chylomicron concentrations are observed between drinks. After consumption of VEG-drink, C18:2n-6 in serum increased. Observed differences in chylomicron FA profile reflect differences in initial FA profile of test drinks. Serum ketone bodies concentrations increase following consumption of BOV-drink. Conclusions: The use of bovine milk fat in IF does neither affect postprandial energy metabolism nor lipemic response in healthy adults, but alters postprandial FA profiles and ketone metabolism. Whether the exact same effects occur in infants requires experimental verification. |
| format |
Article/Letter to editor |
| topic_facet |
bovine milk fat chylomicrons infant formula lipidomics metabolism |
| author |
Hageman, Jeske H.J. Erdõs, Balázs Keijer, Jaap Adriaens, Michiel de Wit, Britt Stañková, Barbora Tvrzická, Eva Arts, Ilja C.W. Nieuwenhuizen, Arie G. |
| author_facet |
Hageman, Jeske H.J. Erdõs, Balázs Keijer, Jaap Adriaens, Michiel de Wit, Britt Stañková, Barbora Tvrzická, Eva Arts, Ilja C.W. Nieuwenhuizen, Arie G. |
| author_sort |
Hageman, Jeske H.J. |
| title |
The Effect of Partly Replacing Vegetable Fat with Bovine Milk Fat in Infant Formula on Postprandial Lipid and Energy Metabolism : A Proof-of-principle Study in Healthy Young Male Adults |
| title_short |
The Effect of Partly Replacing Vegetable Fat with Bovine Milk Fat in Infant Formula on Postprandial Lipid and Energy Metabolism : A Proof-of-principle Study in Healthy Young Male Adults |
| title_full |
The Effect of Partly Replacing Vegetable Fat with Bovine Milk Fat in Infant Formula on Postprandial Lipid and Energy Metabolism : A Proof-of-principle Study in Healthy Young Male Adults |
| title_fullStr |
The Effect of Partly Replacing Vegetable Fat with Bovine Milk Fat in Infant Formula on Postprandial Lipid and Energy Metabolism : A Proof-of-principle Study in Healthy Young Male Adults |
| title_full_unstemmed |
The Effect of Partly Replacing Vegetable Fat with Bovine Milk Fat in Infant Formula on Postprandial Lipid and Energy Metabolism : A Proof-of-principle Study in Healthy Young Male Adults |
| title_sort |
effect of partly replacing vegetable fat with bovine milk fat in infant formula on postprandial lipid and energy metabolism : a proof-of-principle study in healthy young male adults |
| url |
https://research.wur.nl/en/publications/the-effect-of-partly-replacing-vegetable-fat-with-bovine-milk-fat |
| work_keys_str_mv |
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