Integrated physiology and systems biology of PPARa
The Peroxisome Proliferator Activated Receptor alpha (PPARa) is a transcription factor that plays a major role in metabolic regulation. This review addresses the functional role of PPARa in intermediary metabolism and provides a detailed overview of metabolic genes targeted by PPARa, with a focus on liver. A distinction is made between the impact of PPARa on metabolism upon physiological, pharmacological, and nutritional activation. Low and high throughput gene expression analyses have allowed the creation of a comprehensive map illustrating the role of PPARa as master regulator of lipid metabolism via regulation of numerous genes. The map puts PPARa at the center of a regulatory hub impacting fatty acid uptake, fatty acid activation, intracellular fatty acid binding, mitochondrial and peroxisomal fatty acid oxidation, ketogenesis, triglyceride turnover, lipid droplet biology, gluconeogenesis, and bile synthesis/secretion. In addition, PPARa governs the expression of several secreted proteins that exert local and endocrine functions.
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Format: | Article/Letter to editor biblioteca |
Language: | English |
Subjects: | Expression profiling, Lipid metabolism, Liver, Metabolic homeostasis, PPARα, Systems biology, Transcriptional networks, |
Online Access: | https://research.wur.nl/en/publications/integrated-physiology-and-systems-biology-of-ppara |
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dig-wur-nl-wurpubs-4786292024-08-14 Kersten, A.H. Article/Letter to editor Molecular Metabolism 3 (2014) 4 ISSN: 2212-8778 Integrated physiology and systems biology of PPARa 2014 The Peroxisome Proliferator Activated Receptor alpha (PPARa) is a transcription factor that plays a major role in metabolic regulation. This review addresses the functional role of PPARa in intermediary metabolism and provides a detailed overview of metabolic genes targeted by PPARa, with a focus on liver. A distinction is made between the impact of PPARa on metabolism upon physiological, pharmacological, and nutritional activation. Low and high throughput gene expression analyses have allowed the creation of a comprehensive map illustrating the role of PPARa as master regulator of lipid metabolism via regulation of numerous genes. The map puts PPARa at the center of a regulatory hub impacting fatty acid uptake, fatty acid activation, intracellular fatty acid binding, mitochondrial and peroxisomal fatty acid oxidation, ketogenesis, triglyceride turnover, lipid droplet biology, gluconeogenesis, and bile synthesis/secretion. In addition, PPARa governs the expression of several secreted proteins that exert local and endocrine functions. en application/pdf https://research.wur.nl/en/publications/integrated-physiology-and-systems-biology-of-ppara 10.1016/j.molmet.2014.02.002 https://edepot.wur.nl/321233 Expression profiling Lipid metabolism Liver Metabolic homeostasis PPARα Systems biology Transcriptional networks https://creativecommons.org/licenses/by-nc-sa/4.0/ Wageningen University & Research |
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Expression profiling Lipid metabolism Liver Metabolic homeostasis PPARα Systems biology Transcriptional networks Expression profiling Lipid metabolism Liver Metabolic homeostasis PPARα Systems biology Transcriptional networks |
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Expression profiling Lipid metabolism Liver Metabolic homeostasis PPARα Systems biology Transcriptional networks Expression profiling Lipid metabolism Liver Metabolic homeostasis PPARα Systems biology Transcriptional networks Kersten, A.H. Integrated physiology and systems biology of PPARa |
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The Peroxisome Proliferator Activated Receptor alpha (PPARa) is a transcription factor that plays a major role in metabolic regulation. This review addresses the functional role of PPARa in intermediary metabolism and provides a detailed overview of metabolic genes targeted by PPARa, with a focus on liver. A distinction is made between the impact of PPARa on metabolism upon physiological, pharmacological, and nutritional activation. Low and high throughput gene expression analyses have allowed the creation of a comprehensive map illustrating the role of PPARa as master regulator of lipid metabolism via regulation of numerous genes. The map puts PPARa at the center of a regulatory hub impacting fatty acid uptake, fatty acid activation, intracellular fatty acid binding, mitochondrial and peroxisomal fatty acid oxidation, ketogenesis, triglyceride turnover, lipid droplet biology, gluconeogenesis, and bile synthesis/secretion. In addition, PPARa governs the expression of several secreted proteins that exert local and endocrine functions. |
format |
Article/Letter to editor |
topic_facet |
Expression profiling Lipid metabolism Liver Metabolic homeostasis PPARα Systems biology Transcriptional networks |
author |
Kersten, A.H. |
author_facet |
Kersten, A.H. |
author_sort |
Kersten, A.H. |
title |
Integrated physiology and systems biology of PPARa |
title_short |
Integrated physiology and systems biology of PPARa |
title_full |
Integrated physiology and systems biology of PPARa |
title_fullStr |
Integrated physiology and systems biology of PPARa |
title_full_unstemmed |
Integrated physiology and systems biology of PPARa |
title_sort |
integrated physiology and systems biology of ppara |
url |
https://research.wur.nl/en/publications/integrated-physiology-and-systems-biology-of-ppara |
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AT kerstenah integratedphysiologyandsystemsbiologyofppara |
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1813201521949540352 |