The P gene of Newcastle disease virus does not encode an accessory X protein
Many paramyxoviruses encode non-essential accessory proteins that are involved in the regulation of virus replication and inhibition of cellular antiviral responses. It has been suggested that the P gene mRNA of Newcastle disease virus (NDV) encodes an accessory protein ¿ the so-called X protein ¿ by translation initiation at a conserved in-frame AUG codon at position 120. Using a monoclonal antibody that specifically detected the P and X proteins, it was shown that an accessory X protein was not expressed in NDV-infected cells. Recombinant NDV strains in which the AUG was changed into a GCC (Ala) or GUC (Val) codon were viable but showed a reduction in virulence, probably because the amino acid change affected the function of the P and/or V protein.
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| Format: | Article/Letter to editor biblioteca |
| Language: | English |
| Subjects: | c-protein, cells, expression, interferon-antagonist, messenger-rna, pathogenicity, v-protein, |
| Online Access: | https://research.wur.nl/en/publications/the-p-gene-of-newcastle-disease-virus-does-not-encode-an-accessor |
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dig-wur-nl-wurpubs-3627102025-01-23 Peeters, B.P.H. Verbruggen, P. Nelissen, F. de Leeuw, O.S. Article/Letter to editor Journal of General Virology 85 (2004) 8 ISSN: 0022-1317 The P gene of Newcastle disease virus does not encode an accessory X protein 2004 Many paramyxoviruses encode non-essential accessory proteins that are involved in the regulation of virus replication and inhibition of cellular antiviral responses. It has been suggested that the P gene mRNA of Newcastle disease virus (NDV) encodes an accessory protein ¿ the so-called X protein ¿ by translation initiation at a conserved in-frame AUG codon at position 120. Using a monoclonal antibody that specifically detected the P and X proteins, it was shown that an accessory X protein was not expressed in NDV-infected cells. Recombinant NDV strains in which the AUG was changed into a GCC (Ala) or GUC (Val) codon were viable but showed a reduction in virulence, probably because the amino acid change affected the function of the P and/or V protein. en application/pdf https://research.wur.nl/en/publications/the-p-gene-of-newcastle-disease-virus-does-not-encode-an-accessor 10.1099/vir.0.80160-0 https://edepot.wur.nl/34857 c-protein cells expression interferon-antagonist messenger-rna pathogenicity v-protein Wageningen University & Research |
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c-protein cells expression interferon-antagonist messenger-rna pathogenicity v-protein c-protein cells expression interferon-antagonist messenger-rna pathogenicity v-protein |
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c-protein cells expression interferon-antagonist messenger-rna pathogenicity v-protein c-protein cells expression interferon-antagonist messenger-rna pathogenicity v-protein Peeters, B.P.H. Verbruggen, P. Nelissen, F. de Leeuw, O.S. The P gene of Newcastle disease virus does not encode an accessory X protein |
| description |
Many paramyxoviruses encode non-essential accessory proteins that are involved in the regulation of virus replication and inhibition of cellular antiviral responses. It has been suggested that the P gene mRNA of Newcastle disease virus (NDV) encodes an accessory protein ¿ the so-called X protein ¿ by translation initiation at a conserved in-frame AUG codon at position 120. Using a monoclonal antibody that specifically detected the P and X proteins, it was shown that an accessory X protein was not expressed in NDV-infected cells. Recombinant NDV strains in which the AUG was changed into a GCC (Ala) or GUC (Val) codon were viable but showed a reduction in virulence, probably because the amino acid change affected the function of the P and/or V protein. |
| format |
Article/Letter to editor |
| topic_facet |
c-protein cells expression interferon-antagonist messenger-rna pathogenicity v-protein |
| author |
Peeters, B.P.H. Verbruggen, P. Nelissen, F. de Leeuw, O.S. |
| author_facet |
Peeters, B.P.H. Verbruggen, P. Nelissen, F. de Leeuw, O.S. |
| author_sort |
Peeters, B.P.H. |
| title |
The P gene of Newcastle disease virus does not encode an accessory X protein |
| title_short |
The P gene of Newcastle disease virus does not encode an accessory X protein |
| title_full |
The P gene of Newcastle disease virus does not encode an accessory X protein |
| title_fullStr |
The P gene of Newcastle disease virus does not encode an accessory X protein |
| title_full_unstemmed |
The P gene of Newcastle disease virus does not encode an accessory X protein |
| title_sort |
p gene of newcastle disease virus does not encode an accessory x protein |
| url |
https://research.wur.nl/en/publications/the-p-gene-of-newcastle-disease-virus-does-not-encode-an-accessor |
| work_keys_str_mv |
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