Quantification of within- and between-pen transmission of Fouth-and-Mouth disease virus in pigs

Quantified transmission parameters of Foot-and-Mouth Disease Virus (FMDV) are needed for epidemic models used for control and surveillance. In this study, we quantified the within- and between-pen transmission of FMDV in groups of pigs by estimating the daily transmission rate , i.e. the number of secondary infections caused by one infectious pig during one day, using an SIR (susceptible-infectious-removed) model. Within-pen transmission was studied in four groups of ten pigs in which 5 infected and 5 susceptible pigs had direct contact; between-pen transmission was studied in one group of ten pigs in which 5 infected and 5 susceptible pigs had indirect contact. Daily results of virus isolation of oropharyngeal fluid were used to quantify the transmission rate , using Generalised Linear Modelling (GLM) and a maximum likelihood method. In addition, we estimated the expected time to infection of the first pig within a pen Tw and in the indirect-contact pen Tb. The between-pen transmission rate b was estimated to be 0.59 (0.083-4.18) per day, which was significantly lower than the within-pen transmission rate w of 6.14 (3.75-10.06). Tw was 1.6 h, and Tb was 16 h. Our results show that the transmission rate is influenced by contact structure between pigs.

Bibliographic Details

Main Authors:	Eble, P.L., de Koeijer, A.A., Bouma, A., Stegeman, J.A., Dekker, A.
Format:	Article/Letter to editor biblioteca
Language:	English
Subjects:	antibody-response, calves, epidemic, experimental-infection, great-britain, impact, swine-fever virus, vaccination,
Online Access:	https://research.wur.nl/en/publications/quantification-of-within-and-between-pen-transmission-of-fouth-an
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