Generalized AA-amyloidosis in Siamese and Oriental cats
During a 7 year period (1987-1994), 194 Siamese cats including a colour variant designated Oriental cat, were presented for post-mortem examination. Twelve of these animals (6.2%) were diagnosed with amyloidosis. Major gross pathological findings included enlarged pale livers with haemorrhages, pale and swollen spleens, and dilated intestines. Deposits of amyloid were found in these tissues. The amyloid was found to cross-react with anti dog AA- antiserum when examined with peroxidase antiperoxidase (PAP) staining (four cases). Amyloid fibrils were purified by the water extraction method and its major constituting protein (AA) was isolated by gel filtration. Amino acid sequence analysis of this protein from a Siamese cat and an Abyssinian cat revealed a significant difference between these breeds. In the Siamese protein AA two amino acid substitutions (46 R for Q and 52 V for A) were encountered. This finding indicates the existence of a new feline amyloid A protein occurring in the Siamese breed which differs from presently known (apoS)AA-proteins. Additionally, the pedigree analysis of affected cats suggests a familial trait.
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Format: | Article/Letter to editor biblioteca |
Language: | English |
Subjects: | AA amyloid, Abyssinian cat, Amino acid sequence, Amyloid, Amyloidosis, Domestic Shorthair cat, Gene, Liver, Siamese cat, apoSAA, |
Online Access: | https://research.wur.nl/en/publications/generalized-aa-amyloidosis-in-siamese-and-oriental-cats |
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dig-wur-nl-wurpubs-3056832024-08-15 van der Linde-Sipman, J.S. Niewold, T.A. Tooten, P.C.J. de Neijs-Backer, M. Gruys, E. Article/Letter to editor Veterinary Immunology and Immunopathology 56 (1997) 1-2 ISSN: 0165-2427 Generalized AA-amyloidosis in Siamese and Oriental cats 1997 During a 7 year period (1987-1994), 194 Siamese cats including a colour variant designated Oriental cat, were presented for post-mortem examination. Twelve of these animals (6.2%) were diagnosed with amyloidosis. Major gross pathological findings included enlarged pale livers with haemorrhages, pale and swollen spleens, and dilated intestines. Deposits of amyloid were found in these tissues. The amyloid was found to cross-react with anti dog AA- antiserum when examined with peroxidase antiperoxidase (PAP) staining (four cases). Amyloid fibrils were purified by the water extraction method and its major constituting protein (AA) was isolated by gel filtration. Amino acid sequence analysis of this protein from a Siamese cat and an Abyssinian cat revealed a significant difference between these breeds. In the Siamese protein AA two amino acid substitutions (46 R for Q and 52 V for A) were encountered. This finding indicates the existence of a new feline amyloid A protein occurring in the Siamese breed which differs from presently known (apoS)AA-proteins. Additionally, the pedigree analysis of affected cats suggests a familial trait. en application/pdf https://research.wur.nl/en/publications/generalized-aa-amyloidosis-in-siamese-and-oriental-cats 10.1016/S0165-2427(96)05717-0 https://edepot.wur.nl/323786 AA amyloid Abyssinian cat Amino acid sequence Amyloid Amyloidosis Domestic Shorthair cat Gene Liver Siamese cat apoSAA Wageningen University & Research |
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AA amyloid Abyssinian cat Amino acid sequence Amyloid Amyloidosis Domestic Shorthair cat Gene Liver Siamese cat apoSAA AA amyloid Abyssinian cat Amino acid sequence Amyloid Amyloidosis Domestic Shorthair cat Gene Liver Siamese cat apoSAA |
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AA amyloid Abyssinian cat Amino acid sequence Amyloid Amyloidosis Domestic Shorthair cat Gene Liver Siamese cat apoSAA AA amyloid Abyssinian cat Amino acid sequence Amyloid Amyloidosis Domestic Shorthair cat Gene Liver Siamese cat apoSAA van der Linde-Sipman, J.S. Niewold, T.A. Tooten, P.C.J. de Neijs-Backer, M. Gruys, E. Generalized AA-amyloidosis in Siamese and Oriental cats |
description |
During a 7 year period (1987-1994), 194 Siamese cats including a colour variant designated Oriental cat, were presented for post-mortem examination. Twelve of these animals (6.2%) were diagnosed with amyloidosis. Major gross pathological findings included enlarged pale livers with haemorrhages, pale and swollen spleens, and dilated intestines. Deposits of amyloid were found in these tissues. The amyloid was found to cross-react with anti dog AA- antiserum when examined with peroxidase antiperoxidase (PAP) staining (four cases). Amyloid fibrils were purified by the water extraction method and its major constituting protein (AA) was isolated by gel filtration. Amino acid sequence analysis of this protein from a Siamese cat and an Abyssinian cat revealed a significant difference between these breeds. In the Siamese protein AA two amino acid substitutions (46 R for Q and 52 V for A) were encountered. This finding indicates the existence of a new feline amyloid A protein occurring in the Siamese breed which differs from presently known (apoS)AA-proteins. Additionally, the pedigree analysis of affected cats suggests a familial trait. |
format |
Article/Letter to editor |
topic_facet |
AA amyloid Abyssinian cat Amino acid sequence Amyloid Amyloidosis Domestic Shorthair cat Gene Liver Siamese cat apoSAA |
author |
van der Linde-Sipman, J.S. Niewold, T.A. Tooten, P.C.J. de Neijs-Backer, M. Gruys, E. |
author_facet |
van der Linde-Sipman, J.S. Niewold, T.A. Tooten, P.C.J. de Neijs-Backer, M. Gruys, E. |
author_sort |
van der Linde-Sipman, J.S. |
title |
Generalized AA-amyloidosis in Siamese and Oriental cats |
title_short |
Generalized AA-amyloidosis in Siamese and Oriental cats |
title_full |
Generalized AA-amyloidosis in Siamese and Oriental cats |
title_fullStr |
Generalized AA-amyloidosis in Siamese and Oriental cats |
title_full_unstemmed |
Generalized AA-amyloidosis in Siamese and Oriental cats |
title_sort |
generalized aa-amyloidosis in siamese and oriental cats |
url |
https://research.wur.nl/en/publications/generalized-aa-amyloidosis-in-siamese-and-oriental-cats |
work_keys_str_mv |
AT vanderlindesipmanjs generalizedaaamyloidosisinsiameseandorientalcats AT niewoldta generalizedaaamyloidosisinsiameseandorientalcats AT tootenpcj generalizedaaamyloidosisinsiameseandorientalcats AT deneijsbackerm generalizedaaamyloidosisinsiameseandorientalcats AT gruyse generalizedaaamyloidosisinsiameseandorientalcats |
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1813052891761475584 |