Enhancement of dissolution rate of furosemide using a solid dispersion with D-glucosamine HCl
Fil: Han, Yong Ki. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Calidad de Medicamentos; Argentina.
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| Format: | info:eu-repo/semantics/acceptedVersion biblioteca |
| Language: | eng |
| Published: |
2016
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| Subjects: | Furosemide, D-Glucosamine HCl, Solid dispersion, Physical mixture, Dissolution profile, Diuretic activity, |
| Online Access: | http://hdl.handle.net/11086/548801 |
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Furosemide D-Glucosamine HCl Solid dispersion Physical mixture Dissolution profile Diuretic activity Furosemide D-Glucosamine HCl Solid dispersion Physical mixture Dissolution profile Diuretic activity |
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Furosemide D-Glucosamine HCl Solid dispersion Physical mixture Dissolution profile Diuretic activity Furosemide D-Glucosamine HCl Solid dispersion Physical mixture Dissolution profile Diuretic activity Han, Yong Ki Calvo, Romina Giselle Faudone, Sonia Nerina Zitto, Gustavo Gorzalczany, Susana Beatriz Wolfenson, Alberto Enrique Bonafede, Silvina Rosasco, María Ana Segall, Adriana Inés Enhancement of dissolution rate of furosemide using a solid dispersion with D-glucosamine HCl |
| description |
Fil: Han, Yong Ki. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Calidad de Medicamentos; Argentina. |
| format |
info:eu-repo/semantics/acceptedVersion |
| topic_facet |
Furosemide D-Glucosamine HCl Solid dispersion Physical mixture Dissolution profile Diuretic activity |
| author |
Han, Yong Ki Calvo, Romina Giselle Faudone, Sonia Nerina Zitto, Gustavo Gorzalczany, Susana Beatriz Wolfenson, Alberto Enrique Bonafede, Silvina Rosasco, María Ana Segall, Adriana Inés |
| author_facet |
Han, Yong Ki Calvo, Romina Giselle Faudone, Sonia Nerina Zitto, Gustavo Gorzalczany, Susana Beatriz Wolfenson, Alberto Enrique Bonafede, Silvina Rosasco, María Ana Segall, Adriana Inés |
| author_sort |
Han, Yong Ki |
| title |
Enhancement of dissolution rate of furosemide using a solid dispersion with D-glucosamine HCl |
| title_short |
Enhancement of dissolution rate of furosemide using a solid dispersion with D-glucosamine HCl |
| title_full |
Enhancement of dissolution rate of furosemide using a solid dispersion with D-glucosamine HCl |
| title_fullStr |
Enhancement of dissolution rate of furosemide using a solid dispersion with D-glucosamine HCl |
| title_full_unstemmed |
Enhancement of dissolution rate of furosemide using a solid dispersion with D-glucosamine HCl |
| title_sort |
enhancement of dissolution rate of furosemide using a solid dispersion with d-glucosamine hcl |
| publishDate |
2016 |
| url |
http://hdl.handle.net/11086/548801 |
| work_keys_str_mv |
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| _version_ |
1781879602994479104 |
| spelling |
dig-unc-ar-11086-5488012023-09-07T09:58:07Z Enhancement of dissolution rate of furosemide using a solid dispersion with D-glucosamine HCl Han, Yong Ki Calvo, Romina Giselle Faudone, Sonia Nerina Zitto, Gustavo Gorzalczany, Susana Beatriz Wolfenson, Alberto Enrique Bonafede, Silvina Rosasco, María Ana Segall, Adriana Inés Furosemide D-Glucosamine HCl Solid dispersion Physical mixture Dissolution profile Diuretic activity info:eu-repo/semantics/acceptedVersion Fil: Han, Yong Ki. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Calidad de Medicamentos; Argentina. Fil: Calvo, Romina Giselle. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Calidad de Medicamentos; Argentina. Fil: Faudone, Sonia Nerina. Ministerio de Ciencia y Tecnología. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Fil: Zitto, Gustavo. Ministerio de Ciencia y Tecnología. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Fil: Gorzalczany, Susana Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacología; Argentina. Fil: Gorzalczany, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fil: Wolfenson, Alberto Enrique. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación; Argentina. Fil: Wolfenson, Alberto Enrique. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Fil: Wolfenson, Alberto Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física Enrique Gaviola; Argentina. Fil: Bonafede, Silvina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Calidad de Medicamentos; Argentina. Fil: Rosasco, María Ana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Calidad de Medicamentos; Argentina. Fil: Segall, Adriana Inés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Calidad de Medicamentos; Argentina. Furosemide is a potent high ceiling (loop) diuretic mainly used in the treatment of edematous states associated with cardiac, renal, and hepatic failure, and the treatment of hypertension. Furosemide has been classified as a class IV drug as per the biopharmaceutical classification system (BCS). D-Glucosamine HCl was used to increase the aqueous solubility of furosemide. The objective of the present work is to improve de dissolution profile of furosemide by formation of a physical mixture and a solid dispersion with D-glucosamine HCl. The solid dispersion was prepared by solvent method using acetone/water. The dissolution properties and physicochemical properties of furosemide: D-glucosamine HCl physical mixture and solid dispersion were investigated by dissolution test, X-ray diffractometry, infrared spectrometry, differential scanning calorimetry (DSC), microscopy (SEM) and 35Cl Nuclear Quadrupole Resonance (NQR). The diuretic activity was proved comparing the solid dispersion with pure furosemide. This study shows that the dissolution rate of furosemide can be enhanced considerably by formulating it with D-glucosamine HCl, as a physical mixture or as a solid dispersion although cristallinity was maintained. Solid dispersion and pure furosemide showed significant increase in diuresis in rats as compared to the control group. info:eu-repo/semantics/acceptedVersion Fil: Han, Yong Ki. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Calidad de Medicamentos; Argentina. Fil: Calvo, Romina Giselle. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Calidad de Medicamentos; Argentina. Fil: Faudone, Sonia Nerina. Ministerio de Ciencia y Tecnología. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Fil: Zitto, Gustavo. Ministerio de Ciencia y Tecnología. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Fil: Gorzalczany, Susana Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacología; Argentina. Fil: Gorzalczany, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fil: Wolfenson, Alberto Enrique. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación; Argentina. Fil: Wolfenson, Alberto Enrique. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Fil: Wolfenson, Alberto Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física Enrique Gaviola; Argentina. Fil: Bonafede, Silvina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Calidad de Medicamentos; Argentina. Fil: Rosasco, María Ana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Calidad de Medicamentos; Argentina. Fil: Segall, Adriana Inés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Calidad de Medicamentos; Argentina. Química Orgánica 2023-09-05T14:22:47Z 2023-09-05T14:22:47Z 2016 article http://hdl.handle.net/11086/548801 eng De la versión publicada: http://dx.doi.org/10.2174/1573412911666150817223836 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Impreso; Electrónico y/o Digital e-ISSN: 1875-676X ISSN: 1573-4129 |