Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A
Intracellular transport based on molecular motors and its regulation are crucial to the functioning of cells. Filamentary tracks of the cells are abundantly decorated with nonmotile microtubule-associated proteins, such as tau. Motivated by experiments on kinesin-tau interactions [Dixit et al., Science 319, 1086 (2008)] we developed a stochastic model of interacting single-headed motor proteins KIF1A that also takes into account the interactions between motor proteins and tau molecules. Our model reproduces experimental observations and predicts significant effects of tau on bound time and run length which suggest an important role of tau in regulation of kinesin-based transport.
Saved in:
Main Authors: | Sparacino, Javier, Farías, María Gimena, Lamberti, Pedro Walter |
---|---|
Format: | article biblioteca |
Language: | eng |
Published: |
2014-02
|
Subjects: | Motores moleculares, Proteína Tau, Dinámica, |
Online Access: | http://hdl.handle.net/11086/19280 https://doi.org/10.1103/PhysRevE.89.022714 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The polyphenol altenusin inhibits in vitro fibrillization of tau and reduces induced tau pathology in primary neurons
by: Chua, Sook Wern, et al.
Published: (2017-01-09) -
Does Alzheimer's disease exist in all primates? Alzheimer pathology in non-human primates and its pathophysiological implications (I)
by: Toledano Díaz, Adolfo, et al.
Published: (2012) -
Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease
by: Gerrits, Emma, et al. -
d-Pinitol promotes tau dephosphorylation through a cyclin-dependent kinase 5 regulation mechanism: A new potential approach for tauopathies?
by: Medina-Vera, Dina, et al.
Published: (2022-06-27) -
Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism : Possible implication for Alzheimer's disease
by: Denechaud, Marine, et al.