Preliminary pharmacobiological study of new steroidal sapogenins

Preliminary pharmacobiological study of new steroidal sapogenins

Grafiche Pavoniane Artigianelli - 20159 Milano - Via B. Crespi, 30.

Saved in:
Bibliographic Details
Main Authors: González, A. G., Darias, V., Suárez, M. C., Janssen, K.
Other Authors: Instituto de Salud Carlos III
Format: artículo biblioteca
Language:English
Published: 1983
Online Access:http://hdl.handle.net/10261/23794
http://dx.doi.org/10.13039/501100004587
Tags: Add Tag
No Tags, Be the first to tag this record!
id dig-ipna-es-10261-23794
record_format koha
spelling dig-ipna-es-10261-237942016-02-16T07:29:33Z Preliminary pharmacobiological study of new steroidal sapogenins González, A. G. Darias, V. Suárez, M. C. Janssen, K. Instituto de Salud Carlos III Grafiche Pavoniane Artigianelli - 20159 Milano - Via B. Crespi, 30. The chemotherapeutic study of a limited series of steroidal sapogenins from several endemic species of the flora of the Canary Islands is presented here. On the whole, they possess a very weak antibacterial activity, a slight antifungal effect and one of them, vespertilin, displays interesting cytostatic activity (ID$=5 ug/ml). A pharmacodynamic screening carried out on this product mainly revealed veryu slight toxicity, antihistaminic activity and a light tranquillizing effect. The data obtained justify further research. Viene riportato lo studio chemioterapico di una serie limitata di sapogenine steroidee ottenute da diverse specie endemiche della flora delle Isole Canarie. Nel complesso, tali sostanze possiedono una debolissima azione antibatterica, un lieve effetto antifungino e una di esse, la vespertilina, anche un'interessante azione citostatica (DI$=5 ug/ml). Uno screning farmacodinamico effettuato con questo prodotto ha rivelato che la sostanza ha una tossicità trascurabile, e possiede sia attività antiistamínica che un lieve effetto tranquillante. I dati ottenuti giustificano ulteriori indagini. This research was financed by a grant from the Comisión Administrativa del Fondo de Investigaciones Sanitarias de la Seguridad Social (411/81). We also thank the Department of Botany, University of La Laguna, for their assessment, Drs. R. Freire, E. Suárez and C. G. Francisco for the samples of the products and Ms. E. Bayo for her dkilful technical assistance. Peer reviewed 2010-04-30T12:54:15Z 2010-04-30T12:54:15Z 1983 artículo http://purl.org/coar/resource_type/c_6501 Il Farmaco 38(1): pp. 2-8 (1983) http://hdl.handle.net/10261/23794 http://dx.doi.org/10.13039/501100004587 en open 8012720 bytes application/pdf
institution IPNA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-ipna-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IPNA España
language English
description Grafiche Pavoniane Artigianelli - 20159 Milano - Via B. Crespi, 30.
author2 Instituto de Salud Carlos III
author_facet Instituto de Salud Carlos III
González, A. G.
Darias, V.
Suárez, M. C.
Janssen, K.
format artículo
author González, A. G.
Darias, V.
Suárez, M. C.
Janssen, K.
spellingShingle González, A. G.
Darias, V.
Suárez, M. C.
Janssen, K.
Preliminary pharmacobiological study of new steroidal sapogenins
author_sort González, A. G.
title Preliminary pharmacobiological study of new steroidal sapogenins
title_short Preliminary pharmacobiological study of new steroidal sapogenins
title_full Preliminary pharmacobiological study of new steroidal sapogenins
title_fullStr Preliminary pharmacobiological study of new steroidal sapogenins
title_full_unstemmed Preliminary pharmacobiological study of new steroidal sapogenins
title_sort preliminary pharmacobiological study of new steroidal sapogenins
publishDate 1983
url http://hdl.handle.net/10261/23794
http://dx.doi.org/10.13039/501100004587
work_keys_str_mv AT gonzalezag preliminarypharmacobiologicalstudyofnewsteroidalsapogenins
AT dariasv preliminarypharmacobiologicalstudyofnewsteroidalsapogenins
AT suarezmc preliminarypharmacobiologicalstudyofnewsteroidalsapogenins
AT janssenk preliminarypharmacobiologicalstudyofnewsteroidalsapogenins
_version_ 1777669708344983552

Similar Items