Comparison of capsid protein VP1 of the viruses used for the production and challenge of foot-and-mouth disease vaccines in Spain
A significant frequency of amino acid substitutions, that affect important antigenic sites on capsid protein VP1, has been found among viral preparations used for the production and for challenge, in protection assays, of foot-and-mouth disease (FMD) vaccines. The amino acid substitutions present in one of the viruses studied abolished its reactivity with two neutralizing monoclonal antibodies that recognized different epitopes on VP1. Thus, the results obtained illustrate the high potential for antigenic variation introduced by the multiple cycles of growth usually undergone by the strains used for the production and challenge of FMD vaccines. © 1992.
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| Format: | journal article biblioteca |
| Language: | English |
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Elsevier
1992
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| Subjects: | FMD vaccines, Production and challenge viruses, VP1 RNA sequences comparison, |
| Online Access: | http://hdl.handle.net/20.500.12792/5148 http://hdl.handle.net/10261/294906 |
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dig-inia-es-10261-2949062023-02-20T10:43:10Z Comparison of capsid protein VP1 of the viruses used for the production and challenge of foot-and-mouth disease vaccines in Spain González, M. Mateu, M. G. Martínez, M. A. Carrillo García, Mª Cristina Sobrino, F. FMD vaccines Production and challenge viruses VP1 RNA sequences comparison A significant frequency of amino acid substitutions, that affect important antigenic sites on capsid protein VP1, has been found among viral preparations used for the production and for challenge, in protection assays, of foot-and-mouth disease (FMD) vaccines. The amino acid substitutions present in one of the viruses studied abolished its reactivity with two neutralizing monoclonal antibodies that recognized different epitopes on VP1. Thus, the results obtained illustrate the high potential for antigenic variation introduced by the multiple cycles of growth usually undergone by the strains used for the production and challenge of FMD vaccines. © 1992. 2023-02-20T10:43:10Z 2023-02-20T10:43:10Z 1992 journal article Vaccine 10(11): 731-734 (1992) 0264-410X http://hdl.handle.net/20.500.12792/5148 http://hdl.handle.net/10261/294906 10.1016/0264-410X(92)90504-D en none Elsevier |
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FMD vaccines Production and challenge viruses VP1 RNA sequences comparison FMD vaccines Production and challenge viruses VP1 RNA sequences comparison |
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FMD vaccines Production and challenge viruses VP1 RNA sequences comparison FMD vaccines Production and challenge viruses VP1 RNA sequences comparison González, M. Mateu, M. G. Martínez, M. A. Carrillo García, Mª Cristina Sobrino, F. Comparison of capsid protein VP1 of the viruses used for the production and challenge of foot-and-mouth disease vaccines in Spain |
| description |
A significant frequency of amino acid substitutions, that affect important antigenic sites on capsid protein VP1, has been found among viral preparations used for the production and for challenge, in protection assays, of foot-and-mouth disease (FMD) vaccines. The amino acid substitutions present in one of the viruses studied abolished its reactivity with two neutralizing monoclonal antibodies that recognized different epitopes on VP1. Thus, the results obtained illustrate the high potential for antigenic variation introduced by the multiple cycles of growth usually undergone by the strains used for the production and challenge of FMD vaccines. © 1992. |
| format |
journal article |
| topic_facet |
FMD vaccines Production and challenge viruses VP1 RNA sequences comparison |
| author |
González, M. Mateu, M. G. Martínez, M. A. Carrillo García, Mª Cristina Sobrino, F. |
| author_facet |
González, M. Mateu, M. G. Martínez, M. A. Carrillo García, Mª Cristina Sobrino, F. |
| author_sort |
González, M. |
| title |
Comparison of capsid protein VP1 of the viruses used for the production and challenge of foot-and-mouth disease vaccines in Spain |
| title_short |
Comparison of capsid protein VP1 of the viruses used for the production and challenge of foot-and-mouth disease vaccines in Spain |
| title_full |
Comparison of capsid protein VP1 of the viruses used for the production and challenge of foot-and-mouth disease vaccines in Spain |
| title_fullStr |
Comparison of capsid protein VP1 of the viruses used for the production and challenge of foot-and-mouth disease vaccines in Spain |
| title_full_unstemmed |
Comparison of capsid protein VP1 of the viruses used for the production and challenge of foot-and-mouth disease vaccines in Spain |
| title_sort |
comparison of capsid protein vp1 of the viruses used for the production and challenge of foot-and-mouth disease vaccines in spain |
| publisher |
Elsevier |
| publishDate |
1992 |
| url |
http://hdl.handle.net/20.500.12792/5148 http://hdl.handle.net/10261/294906 |
| work_keys_str_mv |
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