Phylogenomic analysis of 11 complete African swine fever virus genome sequences
Viral molecular epidemiology has traditionally analyzed variation in single genes. Whole genome phylogenetic analysis of 123 concatenated genes from 11 ASFV genomes, including E75, a newly sequenced virulent isolate from Spain, identified two clusters. One contained South African isolates from ticks and warthog, suggesting derivation from a sylvatic transmission cycle. The second contained isolates from West Africa and the Iberian Peninsula. Two isolates, from Kenya and Malawi, were outliers. Of the nine genomes within the clusters, seven were within p72 genotype 1. The 11 genomes sequenced comprised only 5 of the 22 p72 genotypes. Comparison of synonymous and non-synonymous mutations at the genome level identified 20 genes subject to selection pressure for diversification. A novel gene of the E75 virus evolved by the fusion of two genes within the 360 multicopy family. Comparative genomics reveals high diversity within a limited sample of the ASFV viral gene pool. © 2010 Elsevier Inc. All rights reserved.
Main Authors: | , , , , , , |
---|---|
Format: | artículo biblioteca |
Language: | English |
Published: |
Elsevier
2010
|
Subjects: | African swine fever virus, Comparison, Phylogenetics, Full-genome sequences, |
Online Access: | http://hdl.handle.net/20.500.12792/985 http://hdl.handle.net/10261/292024 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
dig-inia-es-10261-292024 |
---|---|
record_format |
koha |
spelling |
dig-inia-es-10261-2920242023-02-20T07:24:47Z Phylogenomic analysis of 11 complete African swine fever virus genome sequences de Villiers, E. P. Gallardo, C. Arias, M. da Silva, M. Upton, C. Martin, R. Bishop, R. P. African swine fever virus Comparison Phylogenetics Full-genome sequences Viral molecular epidemiology has traditionally analyzed variation in single genes. Whole genome phylogenetic analysis of 123 concatenated genes from 11 ASFV genomes, including E75, a newly sequenced virulent isolate from Spain, identified two clusters. One contained South African isolates from ticks and warthog, suggesting derivation from a sylvatic transmission cycle. The second contained isolates from West Africa and the Iberian Peninsula. Two isolates, from Kenya and Malawi, were outliers. Of the nine genomes within the clusters, seven were within p72 genotype 1. The 11 genomes sequenced comprised only 5 of the 22 p72 genotypes. Comparison of synonymous and non-synonymous mutations at the genome level identified 20 genes subject to selection pressure for diversification. A novel gene of the E75 virus evolved by the fusion of two genes within the 360 multicopy family. Comparative genomics reveals high diversity within a limited sample of the ASFV viral gene pool. © 2010 Elsevier Inc. All rights reserved. 2023-02-20T07:24:47Z 2023-02-20T07:24:47Z 2010 artículo Virology 400(1): 128-136 (2010) 0042-6822 http://hdl.handle.net/20.500.12792/985 http://hdl.handle.net/10261/292024 10.1016/j.virol.2010.01.019 en none Elsevier |
institution |
INIA ES |
collection |
DSpace |
country |
España |
countrycode |
ES |
component |
Bibliográfico |
access |
En linea |
databasecode |
dig-inia-es |
tag |
biblioteca |
region |
Europa del Sur |
libraryname |
Biblioteca del INIA España |
language |
English |
topic |
African swine fever virus Comparison Phylogenetics Full-genome sequences African swine fever virus Comparison Phylogenetics Full-genome sequences |
spellingShingle |
African swine fever virus Comparison Phylogenetics Full-genome sequences African swine fever virus Comparison Phylogenetics Full-genome sequences de Villiers, E. P. Gallardo, C. Arias, M. da Silva, M. Upton, C. Martin, R. Bishop, R. P. Phylogenomic analysis of 11 complete African swine fever virus genome sequences |
description |
Viral molecular epidemiology has traditionally analyzed variation in single genes. Whole genome phylogenetic analysis of 123 concatenated genes from 11 ASFV genomes, including E75, a newly sequenced virulent isolate from Spain, identified two clusters. One contained South African isolates from ticks and warthog, suggesting derivation from a sylvatic transmission cycle. The second contained isolates from West Africa and the Iberian Peninsula. Two isolates, from Kenya and Malawi, were outliers. Of the nine genomes within the clusters, seven were within p72 genotype 1. The 11 genomes sequenced comprised only 5 of the 22 p72 genotypes. Comparison of synonymous and non-synonymous mutations at the genome level identified 20 genes subject to selection pressure for diversification. A novel gene of the E75 virus evolved by the fusion of two genes within the 360 multicopy family. Comparative genomics reveals high diversity within a limited sample of the ASFV viral gene pool. © 2010 Elsevier Inc. All rights reserved. |
format |
artículo |
topic_facet |
African swine fever virus Comparison Phylogenetics Full-genome sequences |
author |
de Villiers, E. P. Gallardo, C. Arias, M. da Silva, M. Upton, C. Martin, R. Bishop, R. P. |
author_facet |
de Villiers, E. P. Gallardo, C. Arias, M. da Silva, M. Upton, C. Martin, R. Bishop, R. P. |
author_sort |
de Villiers, E. P. |
title |
Phylogenomic analysis of 11 complete African swine fever virus genome sequences |
title_short |
Phylogenomic analysis of 11 complete African swine fever virus genome sequences |
title_full |
Phylogenomic analysis of 11 complete African swine fever virus genome sequences |
title_fullStr |
Phylogenomic analysis of 11 complete African swine fever virus genome sequences |
title_full_unstemmed |
Phylogenomic analysis of 11 complete African swine fever virus genome sequences |
title_sort |
phylogenomic analysis of 11 complete african swine fever virus genome sequences |
publisher |
Elsevier |
publishDate |
2010 |
url |
http://hdl.handle.net/20.500.12792/985 http://hdl.handle.net/10261/292024 |
work_keys_str_mv |
AT devilliersep phylogenomicanalysisof11completeafricanswinefevervirusgenomesequences AT gallardoc phylogenomicanalysisof11completeafricanswinefevervirusgenomesequences AT ariasm phylogenomicanalysisof11completeafricanswinefevervirusgenomesequences AT dasilvam phylogenomicanalysisof11completeafricanswinefevervirusgenomesequences AT uptonc phylogenomicanalysisof11completeafricanswinefevervirusgenomesequences AT martinr phylogenomicanalysisof11completeafricanswinefevervirusgenomesequences AT bishoprp phylogenomicanalysisof11completeafricanswinefevervirusgenomesequences |
_version_ |
1767603288047353856 |