Fast biofoundries: coping with the challenges of biomanufacturing

Biofoundries are highly automated facilities that enable the rapid and efficient design, build, test, and learn cycle of biomanufacturing and engineering biology, which is applicable to both research and industrial production. However, developing a biofoundry platform can be expensive and time consuming. A biofoundry should grow organically, starting from a basic platform but with a vision for automation, equipment interoperability, and efficiency. By thinking about strategies early in the process through process planning, simulation, and optimization, bottlenecks can be identified and resolved. Here, we provide a survey of technological solutions in biofoundries and their advantages and limitations. We explore possible pathways towards the creation of a functional, early-phase biofoundry, and strategies towards long-term sustainability.

Bibliographic Details

Main Authors:	Tellechea-Luzardo, Jonathan, Otero-Muras, Irene, Goñi-Moreno, Ángel, Carbonell-Bejerano, Pablo
Other Authors:	Manchester Synthetic Biology Research Centre for Fine and Speciality Chemicals
Format:	artículo de revisión biblioteca
Language:	English
Published:	Elsevier 2022-07
Subjects:	Biocomputation, Engineering biology, Laboratory automation, Biofoundry,
Online Access:	http://hdl.handle.net/10261/274871 http://dx.doi.org/10.13039/100012818 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003329 https://api.elsevier.com/content/abstract/scopus_id/85122499084
Tags:	Add Tag No Tags, Be the first to tag this record!