Efficacy of an anthelmintic combination in sheep infected with Fasciola hepatica resistant to albendazole and clorsulon
4 páginas.
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| Format: | artículo biblioteca |
| Language: | English |
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Elsevier
2014-01
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| Subjects: | Albendazole, Anthelmintic resistance, Clorsulon, Drug combination, Fasciola hepatica, Sheep, |
| Online Access: | http://hdl.handle.net/10261/92114 http://dx.doi.org/10.13039/100007652 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100000780 |
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dig-igm-es-10261-921142021-04-13T15:13:16Z Efficacy of an anthelmintic combination in sheep infected with Fasciola hepatica resistant to albendazole and clorsulon Martínez Valladares, María Cordero Pérez, M. Rojo Vázquez, Francisco Antonio CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) Ministerio de Educación y Ciencia (España) Consejo Superior de Investigaciones Científicas (España) European Commission Albendazole Anthelmintic resistance Clorsulon Drug combination Fasciola hepatica Sheep 4 páginas. In the current study, we identified five sheep flocks with fasciolosis in the province of León (northwestern Spain) in order to determine the anthelmintic resistance status to three commonly used anthelmintics, namely albendazole (ABZ), triclabendazole (TCBZ) and clorsulon (CLOR). The identification of one flock resistant to ABZ and CLOR was shown after the faecal egg count reduction test (FECRT). The reductions in eggs per gram values were -17.6% and -68% against immature and adult flukes, respectively, after ABZ treatment; 85.15% and 44.91% against immature and adult flukes, respectively, after CLOR treatment; and 97.06% against both stages, after the administration of TCBZ. As an alternative to control the infection, two combinations of ABZ and CLOR were tested. In the first, both drugs were administered at the recommended dose of each; in this case, the efficiency reached values above 95% against both immature and adult flukes. However, when the combined drugs were administered at half the recommended dose of each, the efficiency of the combination was very low, i.e. 16.67% and -11.11% against mature and immature flukes, respectively. In conclusion, this preliminary report suggests a possible interaction between ABZ and CLOR after their joint administration. However, these results should be confirmed in other flocks. This study has been funded by the national Projects INIA-MEC, RTA2006-00183-C03-02 and RTA2010-00094-C03-02. The work of María Martínez-Valladares has been supported by a postdoctoral Jae-Doc contract from the Consejo Superior de Investigaciones Científicas (CSIC) and co-funded by the European Social Fund. Peer reviewed 2014-02-20T09:32:05Z 2014-02-20T09:32:05Z 2014-01 artículo http://purl.org/coar/resource_type/c_6501 Experimental Parasitology 136(1) : 59-62 (2014) 0014-4894 http://hdl.handle.net/10261/92114 10.1016/j.exppara.2013.10.010 http://dx.doi.org/10.13039/100007652 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100000780 en http://dx.doi.org/10.1016/j.exppara.2013.10.010 open Elsevier |
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Albendazole Anthelmintic resistance Clorsulon Drug combination Fasciola hepatica Sheep Albendazole Anthelmintic resistance Clorsulon Drug combination Fasciola hepatica Sheep |
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Albendazole Anthelmintic resistance Clorsulon Drug combination Fasciola hepatica Sheep Albendazole Anthelmintic resistance Clorsulon Drug combination Fasciola hepatica Sheep Martínez Valladares, María Cordero Pérez, M. Rojo Vázquez, Francisco Antonio Efficacy of an anthelmintic combination in sheep infected with Fasciola hepatica resistant to albendazole and clorsulon |
| description |
4 páginas. |
| author2 |
CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) |
| author_facet |
CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) Martínez Valladares, María Cordero Pérez, M. Rojo Vázquez, Francisco Antonio |
| format |
artículo |
| topic_facet |
Albendazole Anthelmintic resistance Clorsulon Drug combination Fasciola hepatica Sheep |
| author |
Martínez Valladares, María Cordero Pérez, M. Rojo Vázquez, Francisco Antonio |
| author_sort |
Martínez Valladares, María |
| title |
Efficacy of an anthelmintic combination in sheep infected with Fasciola hepatica resistant to albendazole and clorsulon |
| title_short |
Efficacy of an anthelmintic combination in sheep infected with Fasciola hepatica resistant to albendazole and clorsulon |
| title_full |
Efficacy of an anthelmintic combination in sheep infected with Fasciola hepatica resistant to albendazole and clorsulon |
| title_fullStr |
Efficacy of an anthelmintic combination in sheep infected with Fasciola hepatica resistant to albendazole and clorsulon |
| title_full_unstemmed |
Efficacy of an anthelmintic combination in sheep infected with Fasciola hepatica resistant to albendazole and clorsulon |
| title_sort |
efficacy of an anthelmintic combination in sheep infected with fasciola hepatica resistant to albendazole and clorsulon |
| publisher |
Elsevier |
| publishDate |
2014-01 |
| url |
http://hdl.handle.net/10261/92114 http://dx.doi.org/10.13039/100007652 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100000780 |
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| _version_ |
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