Anthelmintic activity of aminoalcohol and diamine derivatives against the gastrointestinal nematode Teladorsagia circumcincta
11 páginas, 5 figuras, 4 tablas.
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| Format: | artículo biblioteca |
| Language: | English |
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Elsevier BV
2021
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| Subjects: | Teladorsagia circumcincta, Anthelmintics, Aminoalcohol, Diamine, In vitro assays, |
| Online Access: | http://hdl.handle.net/10261/245330 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100014180 |
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dig-igm-es-10261-2453302022-08-12T04:32:21Z Anthelmintic activity of aminoalcohol and diamine derivatives against the gastrointestinal nematode Teladorsagia circumcincta Valderas García, E. De La Vega, J. Álvarez Bardón, M. Castilla Gómez de Agüero, Verónica Escarcena, Ricardo López-Pérez, J. L. Rojo Vázquez, Francisco Antonio San Feliciano, A. del Olmo, Esther Balaña-Fouce, Rafael Martínez Valladares, María Ministerio de Economía y Competitividad (España) Junta de Castilla y León European Commission Valderas García, Elora [0000-0002-9970-896X] Castilla Gómez de Agüero, Verónica [0000-0002-6797-0170] Martínez Valladares, María [0000-0002-3723-1895] Rojo Vázquez, Francisco A. [0000-0001-5913-0131] Teladorsagia circumcincta Anthelmintics Aminoalcohol Diamine In vitro assays 11 páginas, 5 figuras, 4 tablas. Gastrointestinal nematodes (GIN) infections are a serious problem in livestock production due to the great economic losses they cause. Their control is increasingly difficult because of the rapid development of drug resistance and the limited number of available drugs. Therefore, this study evaluated 18 aminoalcohol and 16 diamine derivatives against eggs, first and third stage larvae from a susceptible and a resistant isolate of Tela-dorsagia circumcincta collected from sheep. The effectiveness of the in vitro anthelmintic activity of the com-pounds was evaluated using three different procedures: Egg Hatch Test (EHT), Larval Mortality Test (LMT) and Larval Migration Inhibition Test (LMIT). Those compounds with activities higher than 90 % in the initial screening at 50 μM were selected to determine their half maximal effective concentration (EC50). In parallel, cytotoxicity assays were conducted on Caco2 and HepG2 cell lines to calculate Selectivity Indexes (SI) for each compound. The diamine 30 presented the best results in preventing egg hatching, displaying the lowest EC50 value (1.01 ±0.04 μM) of all compounds tested and the highest SI (21.21 vs. Caco-2 cells). For the LMIT, the diamine 34 showed the highest efficacy, with EC50 values of 2.67 ±0.08 and 3.02 ±0.09 μM on the susceptible and resistant isolate of the parasite, respectively. We are grateful to Dave Bartley, from Moredun Research Institute for providing the triple-resistant isolate of T. circumcincta. RE thank the RICET contract (E07D401988BR) EC Programs. Financial support came from MINECO: RETOS (AGL2016-79813-C2-1R/2R) and Junta de Castilla y León (JCyL) co-financed by FEDER, UE (LE020P17). EVG was funded by FPU16/03536; JV, VCGA and MAB are recipients of Junta de Castilla y Leon and European Social Found (ESF)’s Fellowships Scheme for Doctoral Training Programs. (JCYL-USAL35B, LE082-18, LE051-18, respectively) and MMV by the Spanish “Ramon y Cajal” Programme (Ministerio de Economía y Competitividad; RYC-2015-18368). Peer reviewed 2021-07-06T11:00:10Z 2021-07-06T11:00:10Z 2021 2021-07-06T11:00:11Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1016/j.vetpar.2021.109496 issn: 0304-4017 Veterinary Parasitology 296: 109496 (2021) http://hdl.handle.net/10261/245330 10.1016/j.vetpar.2021.109496 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100014180 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-79813-C2-1-R info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-79813-C2-2-R info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RYC-2015-18368 Postprint http://dx.doi.org/10.1016/j.vetpar.2021.109496 Sí open Elsevier BV |
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Teladorsagia circumcincta Anthelmintics Aminoalcohol Diamine In vitro assays Teladorsagia circumcincta Anthelmintics Aminoalcohol Diamine In vitro assays |
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Teladorsagia circumcincta Anthelmintics Aminoalcohol Diamine In vitro assays Teladorsagia circumcincta Anthelmintics Aminoalcohol Diamine In vitro assays Valderas García, E. De La Vega, J. Álvarez Bardón, M. Castilla Gómez de Agüero, Verónica Escarcena, Ricardo López-Pérez, J. L. Rojo Vázquez, Francisco Antonio San Feliciano, A. del Olmo, Esther Balaña-Fouce, Rafael Martínez Valladares, María Anthelmintic activity of aminoalcohol and diamine derivatives against the gastrointestinal nematode Teladorsagia circumcincta |
| description |
11 páginas, 5 figuras, 4 tablas. |
| author2 |
Ministerio de Economía y Competitividad (España) |
| author_facet |
Ministerio de Economía y Competitividad (España) Valderas García, E. De La Vega, J. Álvarez Bardón, M. Castilla Gómez de Agüero, Verónica Escarcena, Ricardo López-Pérez, J. L. Rojo Vázquez, Francisco Antonio San Feliciano, A. del Olmo, Esther Balaña-Fouce, Rafael Martínez Valladares, María |
| format |
artículo |
| topic_facet |
Teladorsagia circumcincta Anthelmintics Aminoalcohol Diamine In vitro assays |
| author |
Valderas García, E. De La Vega, J. Álvarez Bardón, M. Castilla Gómez de Agüero, Verónica Escarcena, Ricardo López-Pérez, J. L. Rojo Vázquez, Francisco Antonio San Feliciano, A. del Olmo, Esther Balaña-Fouce, Rafael Martínez Valladares, María |
| author_sort |
Valderas García, E. |
| title |
Anthelmintic activity of aminoalcohol and diamine derivatives against the gastrointestinal nematode Teladorsagia circumcincta |
| title_short |
Anthelmintic activity of aminoalcohol and diamine derivatives against the gastrointestinal nematode Teladorsagia circumcincta |
| title_full |
Anthelmintic activity of aminoalcohol and diamine derivatives against the gastrointestinal nematode Teladorsagia circumcincta |
| title_fullStr |
Anthelmintic activity of aminoalcohol and diamine derivatives against the gastrointestinal nematode Teladorsagia circumcincta |
| title_full_unstemmed |
Anthelmintic activity of aminoalcohol and diamine derivatives against the gastrointestinal nematode Teladorsagia circumcincta |
| title_sort |
anthelmintic activity of aminoalcohol and diamine derivatives against the gastrointestinal nematode teladorsagia circumcincta |
| publisher |
Elsevier BV |
| publishDate |
2021 |
| url |
http://hdl.handle.net/10261/245330 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100014180 |
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