Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation
16 páginas, 7 figuras.
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| Format: | artículo biblioteca |
| Language: | English |
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Taylor & Francis
2018
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| Subjects: | NK cells, CD8 T cells, Bm1, MHC class I skin graft, Transplantation, Graft rejection, |
| Online Access: | http://hdl.handle.net/10261/174799 http://dx.doi.org/10.13039/501100004587 http://dx.doi.org/10.13039/501100014180 |
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dig-igm-es-10261-1747992022-04-08T06:31:40Z Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation Rodríguez Barbosa, J. I. Ferreras, Mª del Carmen Buhler, L. Jones, N. D. Sneider, P. Pérez Simón, J. A. Del Río, María Luisa Junta de Castilla y León Instituto de Salud Carlos III Swiss National Science Foundation NK cells CD8 T cells Bm1 MHC class I skin graft Transplantation Graft rejection 16 páginas, 7 figuras. Natural killer (NK) cells are a population of innate type I lymphoid cells essential for early anti-viral responses and are known to modulate the course of humoral and cellular-mediated T cell responses. We assessed the role of NK cells in allogeneic CD8T cell-mediated responses in an immunocompetent mouse model across an MHC class I histocompatibility barrier to determine its impact in therapeutic clinical interventions with polyclonal or monoclonal antibodies (mAbs) targeting lymphoid cells in transplantation. The administration of an NK cell depleting antibody to either CD8T cell replete or CD8T cell-depleted naive C57BL/6 immunocompetent mice accelerated graft rejection. This accelerated rejection response was associated with an in vivo increased cytotoxic activity of CD8T cells against bm1 allogeneic hematopoietic cells and bm1 skin allografts. These findings show that NK cells were implicated in the control host anti-donor cytotoxic responses, likely by competing for common cell growth factors in both CD8T cell replete and CD8T cell-depleted mice, the latter reconstituting in response to lymphopenia. Our data calls for precaution in solid organ transplantation under tolerogenic protocols involving extensive depletion of lymphocytes. These pharmacological biologics with depleting properties over NK cells may accelerate graft rejection and promote aggressive CD8T cell cytotoxic alloresponses refractory to current immunosuppression. This work has been supported by grant FIS PI# 1300029 (Fondo de Investigaciones Sanitarias, Ministry of Health, Spanish Government and co-funded by European Union ERDF/ESF, “Investing in your future”), LE093U13 and Unit of Excellence Research UIC #012 (Department of Education of the Regional Government, Junta de Castilla y Leon) and Gerencia Regional de Salud (BIO/01/15) to JIRB, and by Miguel Servet National Grant (Health National Organization Research) CP12/03063, CPII17/00002 and FIS PI16/00002 (Instituto de Salud Carlos III and cofunded by European Union ERDF/ESF, “Investing in your future”), and Gerencia Regional de Salud GRS963/A/2014, GRS1142/A/2015 and GRS 1505/A/2017 to M.L.R.G. This work has been partially funded by the National Network CIBERONC (oncology research) CB16/12/00480. P.S. is funded by grant 31003A-17-6256 of the Swiss National Science Foundation. We thank University of Leon for providing funding to cover publication expenses. Peer reviewed 2019-01-28T09:44:03Z 2019-01-28T09:44:03Z 2018 artículo http://purl.org/coar/resource_type/c_6501 MABS, 10 (7): 1030-1044 (2018) 1942-0862 http://hdl.handle.net/10261/174799 10.1080/19420862.2018.1502127 1942-0870 http://dx.doi.org/10.13039/501100004587 http://dx.doi.org/10.13039/501100014180 30036156 en http://dx.doi.org/10.1080/19420862.2018.1502127 Sí open Taylor & Francis |
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NK cells CD8 T cells Bm1 MHC class I skin graft Transplantation Graft rejection NK cells CD8 T cells Bm1 MHC class I skin graft Transplantation Graft rejection |
| spellingShingle |
NK cells CD8 T cells Bm1 MHC class I skin graft Transplantation Graft rejection NK cells CD8 T cells Bm1 MHC class I skin graft Transplantation Graft rejection Rodríguez Barbosa, J. I. Ferreras, Mª del Carmen Buhler, L. Jones, N. D. Sneider, P. Pérez Simón, J. A. Del Río, María Luisa Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation |
| description |
16 páginas, 7 figuras. |
| author2 |
Junta de Castilla y León |
| author_facet |
Junta de Castilla y León Rodríguez Barbosa, J. I. Ferreras, Mª del Carmen Buhler, L. Jones, N. D. Sneider, P. Pérez Simón, J. A. Del Río, María Luisa |
| format |
artículo |
| topic_facet |
NK cells CD8 T cells Bm1 MHC class I skin graft Transplantation Graft rejection |
| author |
Rodríguez Barbosa, J. I. Ferreras, Mª del Carmen Buhler, L. Jones, N. D. Sneider, P. Pérez Simón, J. A. Del Río, María Luisa |
| author_sort |
Rodríguez Barbosa, J. I. |
| title |
Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation |
| title_short |
Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation |
| title_full |
Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation |
| title_fullStr |
Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation |
| title_full_unstemmed |
Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation |
| title_sort |
therapeutic implications of nk cell regulation of allogeneic cd8 t cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation |
| publisher |
Taylor & Francis |
| publishDate |
2018 |
| url |
http://hdl.handle.net/10261/174799 http://dx.doi.org/10.13039/501100004587 http://dx.doi.org/10.13039/501100014180 |
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