Evaluation of 4-Nonylphenol in vivo exposure in Dreissena polymorpha: Bioaccumulation, steroid levels and oxidative stress
Nonylphenol (NP) represents the most critical metabolite of alkylphenols (APs) and alkylphenol ethoxylates (APEs), non-ionic surfactants widely used in the formulation of domestic and industrial products. On the basis of in vitro and in vivo animal studies 4-nonylphenol (4-NP) is considered an endocrine disrupting chemical (EDC). The evidence to date indicates that mollusks are able to synthesize sex steroids from the precursor cholesterol and their endocrine pathways are theoretically susceptible to disruption. The aim of this study was to investigate the endocrine modulating potency of 4-NP in the freshwater mussel Dreissena polymorpha by looking at endogenous steroid levels in control and exposed individuals. 4-NP bioaccumulation in mussels tissues and alterations in the activity of enzymes related both to oxidative stress (catalase - CAT- and glutathione peroxidase - GPX-) and phase II metabolism (glutathione-S-transferase - GST-) were also assessed. The results highlighted a build-up of 4-NP in exposed mussels and an overall decrease of 17-beta-estradiol and testosterone levels. On the other hand this chemical at the tested concentrations does not interfere with the antioxidant defense mechanisms in D. polymorpha. The mechanisms by which 4-NP alter steroids levels are unknown and require more in-depth investigations.
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Format: | artículo biblioteca |
Language: | English |
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Elsevier
2010
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Subjects: | Dreissena polymorpha, 4-nonylphenol, Sex steroids, Oxidative stress, |
Online Access: | http://hdl.handle.net/10261/45044 |
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dig-idaea-es-10261-450442020-07-03T12:32:22Z Evaluation of 4-Nonylphenol in vivo exposure in Dreissena polymorpha: Bioaccumulation, steroid levels and oxidative stress Riva, Consuelo Porte Visa, Cinta Binelli, Andrea Provini, Alfredo Dreissena polymorpha 4-nonylphenol Sex steroids Oxidative stress Nonylphenol (NP) represents the most critical metabolite of alkylphenols (APs) and alkylphenol ethoxylates (APEs), non-ionic surfactants widely used in the formulation of domestic and industrial products. On the basis of in vitro and in vivo animal studies 4-nonylphenol (4-NP) is considered an endocrine disrupting chemical (EDC). The evidence to date indicates that mollusks are able to synthesize sex steroids from the precursor cholesterol and their endocrine pathways are theoretically susceptible to disruption. The aim of this study was to investigate the endocrine modulating potency of 4-NP in the freshwater mussel Dreissena polymorpha by looking at endogenous steroid levels in control and exposed individuals. 4-NP bioaccumulation in mussels tissues and alterations in the activity of enzymes related both to oxidative stress (catalase - CAT- and glutathione peroxidase - GPX-) and phase II metabolism (glutathione-S-transferase - GST-) were also assessed. The results highlighted a build-up of 4-NP in exposed mussels and an overall decrease of 17-beta-estradiol and testosterone levels. On the other hand this chemical at the tested concentrations does not interfere with the antioxidant defense mechanisms in D. polymorpha. The mechanisms by which 4-NP alter steroids levels are unknown and require more in-depth investigations. Ministrerio de Medio Ambiente under project ref. 041/SGTB/2007/1.1. Peer reviewed 2012-02-02T10:58:46Z 2012-02-02T10:58:46Z 2010 artículo http://purl.org/coar/resource_type/c_6501 Comparative Biochemistry and Physiology - C - Toxicology and Pharmacology 0010-406X http://hdl.handle.net/10261/45044 10.1016/j.cbpc.2010.04.004 en http://dx.doi.org/10.1016/j.cbpc.2010.04.004 none Elsevier |
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Dreissena polymorpha 4-nonylphenol Sex steroids Oxidative stress Dreissena polymorpha 4-nonylphenol Sex steroids Oxidative stress |
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Dreissena polymorpha 4-nonylphenol Sex steroids Oxidative stress Dreissena polymorpha 4-nonylphenol Sex steroids Oxidative stress Riva, Consuelo Porte Visa, Cinta Binelli, Andrea Provini, Alfredo Evaluation of 4-Nonylphenol in vivo exposure in Dreissena polymorpha: Bioaccumulation, steroid levels and oxidative stress |
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Nonylphenol (NP) represents the most critical metabolite of alkylphenols (APs) and alkylphenol ethoxylates (APEs), non-ionic surfactants widely used in the formulation of domestic and industrial products. On the basis of in vitro and in vivo animal studies 4-nonylphenol (4-NP) is considered an endocrine disrupting chemical (EDC). The evidence to date indicates that mollusks are able to synthesize sex steroids from the precursor cholesterol and their endocrine pathways are theoretically susceptible to disruption. The aim of this study was to investigate the endocrine modulating potency of 4-NP in the freshwater mussel Dreissena polymorpha by looking at endogenous steroid levels in control and exposed individuals. 4-NP bioaccumulation in mussels tissues and alterations in the activity of enzymes related both to oxidative stress (catalase - CAT- and glutathione peroxidase - GPX-) and phase II metabolism (glutathione-S-transferase - GST-) were also assessed. The results highlighted a build-up of 4-NP in exposed mussels and an overall decrease of 17-beta-estradiol and testosterone levels. On the other hand this chemical at the tested concentrations does not interfere with the antioxidant defense mechanisms in D. polymorpha. The mechanisms by which 4-NP alter steroids levels are unknown and require more in-depth investigations. |
format |
artículo |
topic_facet |
Dreissena polymorpha 4-nonylphenol Sex steroids Oxidative stress |
author |
Riva, Consuelo Porte Visa, Cinta Binelli, Andrea Provini, Alfredo |
author_facet |
Riva, Consuelo Porte Visa, Cinta Binelli, Andrea Provini, Alfredo |
author_sort |
Riva, Consuelo |
title |
Evaluation of 4-Nonylphenol in vivo exposure in Dreissena polymorpha: Bioaccumulation, steroid levels and oxidative stress |
title_short |
Evaluation of 4-Nonylphenol in vivo exposure in Dreissena polymorpha: Bioaccumulation, steroid levels and oxidative stress |
title_full |
Evaluation of 4-Nonylphenol in vivo exposure in Dreissena polymorpha: Bioaccumulation, steroid levels and oxidative stress |
title_fullStr |
Evaluation of 4-Nonylphenol in vivo exposure in Dreissena polymorpha: Bioaccumulation, steroid levels and oxidative stress |
title_full_unstemmed |
Evaluation of 4-Nonylphenol in vivo exposure in Dreissena polymorpha: Bioaccumulation, steroid levels and oxidative stress |
title_sort |
evaluation of 4-nonylphenol in vivo exposure in dreissena polymorpha: bioaccumulation, steroid levels and oxidative stress |
publisher |
Elsevier |
publishDate |
2010 |
url |
http://hdl.handle.net/10261/45044 |
work_keys_str_mv |
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1777669215485952000 |