Presence of Visna/Maedi Virus in Post-Vaccination Granulomas in Naturally-Infected Sheep: a New Factor For Virus Spread?
Trabajo presentado en el Joint ESVP and ECVP Congress, celebrado en Cluj-Napoca (Rumanía), del 5 al 8 de septiembre de 2018
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2018-09-05
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dig-idab-es-10261-1921512020-04-16T07:11:59Z Presence of Visna/Maedi Virus in Post-Vaccination Granulomas in Naturally-Infected Sheep: a New Factor For Virus Spread? Miguel, Ricardo de Asín, Javier Echeverría, Irache Gómez-Arrebola, Carmen Andrés, Damián F. de Pérez, Marta M. Reina, Ramsés Luján, Lluís Trabajo presentado en el Joint ESVP and ECVP Congress, celebrado en Cluj-Napoca (Rumanía), del 5 al 8 de septiembre de 2018 Introduction: In sheep, post-vaccination granulomas are a constant reaction after inoculation with vaccines containing aluminium-based adjuvants. These granulomas can be very persistent, sometimes lasting more than 15 months. Presence of multiple post-vaccination granulomas in the same animal can lead to chronic immune system stimulation and to the development of the ovine autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome). Small ruminant lentiviruses (SRLV) infection is widespread and SRLV replicate in activated macrophages. The objective of this work is to report for the first time the active replication of SRLV in post-vaccination granulomas in sheep. Materials and Methods: Eleven adult, naturally SRLV-infected sheep showing clinical lentiviral arthritis were selected. Eight doses of commercial, aluminium-containing vaccines were inoculated in a period of 70 days to all animals. Granulomas were sampled and a study including pathology, cell culture (RT activity quantification), PCR and viral sequencing was carried out. SRLV circulating strains in each animal were also evaluated in peripheral blood mononuclear cells and spleen. Results: SRLV could be detected in post-vaccination granulomas in 5 (45.5%) sheep by cell culture and PCR. Viral sequences belonged to genotypes A and B and evinced compartmentalization according to the different tissues analysed including granulomas. Conclusions: Persistent granulomatous inflammatory reactions induced by vaccines allow in situ SRLV replication. As macrophages from these granulomas can be found in lymph nodes, SRLV may spread throughout the lymphatic system and likely increase the body viral load. The role of post-vaccination granulomas in the spread of sheep SRLV needs to be considered. Peer reviewed 2019-10-04T09:28:27Z 2019-10-04T09:28:27Z 2018-09-05 comunicación de congreso http://purl.org/coar/resource_type/c_5794 Joint ESVP and ECVP Congress (2018) http://hdl.handle.net/10261/192151 en Sí none |
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biblioteca |
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Biblioteca del IDAB España |
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English |
| description |
Trabajo presentado en el Joint ESVP and ECVP Congress, celebrado en Cluj-Napoca (Rumanía), del 5 al 8 de septiembre de 2018 |
| format |
comunicación de congreso |
| author |
Miguel, Ricardo de Asín, Javier Echeverría, Irache Gómez-Arrebola, Carmen Andrés, Damián F. de Pérez, Marta M. Reina, Ramsés Luján, Lluís |
| spellingShingle |
Miguel, Ricardo de Asín, Javier Echeverría, Irache Gómez-Arrebola, Carmen Andrés, Damián F. de Pérez, Marta M. Reina, Ramsés Luján, Lluís Presence of Visna/Maedi Virus in Post-Vaccination Granulomas in Naturally-Infected Sheep: a New Factor For Virus Spread? |
| author_facet |
Miguel, Ricardo de Asín, Javier Echeverría, Irache Gómez-Arrebola, Carmen Andrés, Damián F. de Pérez, Marta M. Reina, Ramsés Luján, Lluís |
| author_sort |
Miguel, Ricardo de |
| title |
Presence of Visna/Maedi Virus in Post-Vaccination Granulomas in Naturally-Infected Sheep: a New Factor For Virus Spread? |
| title_short |
Presence of Visna/Maedi Virus in Post-Vaccination Granulomas in Naturally-Infected Sheep: a New Factor For Virus Spread? |
| title_full |
Presence of Visna/Maedi Virus in Post-Vaccination Granulomas in Naturally-Infected Sheep: a New Factor For Virus Spread? |
| title_fullStr |
Presence of Visna/Maedi Virus in Post-Vaccination Granulomas in Naturally-Infected Sheep: a New Factor For Virus Spread? |
| title_full_unstemmed |
Presence of Visna/Maedi Virus in Post-Vaccination Granulomas in Naturally-Infected Sheep: a New Factor For Virus Spread? |
| title_sort |
presence of visna/maedi virus in post-vaccination granulomas in naturally-infected sheep: a new factor for virus spread? |
| publishDate |
2018-09-05 |
| url |
http://hdl.handle.net/10261/192151 |
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