Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women
Iron deficiency anaemia is a worldwide health problem. We studied the influence of consuming an iron fortified fruit juice on iron status in menstruating women. A randomised double-blind placebo-controlled study of 16-weeks of duration was performed. Two groups: P group (n=58) or F group (n=64) consumed, as a supplement to their usual diet, 500 mL/day of placebo fruit juice or iron-fortified fruit juice, respectively. The iron fortified-juice, containing microencapsulated iron pyrophosphate, provided 18 mg of iron (100% of the recommended dietary allowance per day). At baseline and monthly, dietary intake, body weight, and iron parameters were determined: total red blood cells, haematocrit, mean corpuscular volume (MCV), red blood cell distribution width (RDW), haemoglobin, serum iron, serum ferritin, serum transferrin, transferrin saturation, soluble transferrin receptor (sTfR-2), and zinc protoporphyrin (ZnPP). The fruit juices consumption involved increased intake of carbohydrates and vitamin C, and increased body mass index within normal limits. Ferritin was higher in F after week 4 (p<0•05) and became 80% higher than in P after week 16 (p<0•001), and transferrin decreased in F group compared to P group after week 4 (p<0•001). RDW was higher at weeks 4 and 8 in F compared to P (p<0•05). Transferrin saturation increased after week 8, and haematocrit, MCV, and haemoglobin increased after week 12, in F compared to P. Serum iron did not change. sTfR and ZnPP decreased in F at week 16 (p<0•05). Iron pyrophosphate fortified fruit juice improves iron status and may be used to prevent iron deficiency anaemia. This trial was register at clinicaltrials.gov as NCT01135576.
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Format: | artículo biblioteca |
Language: | English |
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2011-02-25
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Subjects: | Fortification, Ferric pyrophosphate, iron-deficiency anaemia, iron status, women, |
Online Access: | http://hdl.handle.net/10261/32822 |
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dig-ictan-es-10261-328222017-05-24T13:44:29Z Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women Blanco Rojo, R. Pérez Granados, Ana M. Toxqui, Laura González-Vizcayno, Carmen Delgado, Marco A. Vaquero, M. Pilar Fortification Ferric pyrophosphate iron-deficiency anaemia iron status women Iron deficiency anaemia is a worldwide health problem. We studied the influence of consuming an iron fortified fruit juice on iron status in menstruating women. A randomised double-blind placebo-controlled study of 16-weeks of duration was performed. Two groups: P group (n=58) or F group (n=64) consumed, as a supplement to their usual diet, 500 mL/day of placebo fruit juice or iron-fortified fruit juice, respectively. The iron fortified-juice, containing microencapsulated iron pyrophosphate, provided 18 mg of iron (100% of the recommended dietary allowance per day). At baseline and monthly, dietary intake, body weight, and iron parameters were determined: total red blood cells, haematocrit, mean corpuscular volume (MCV), red blood cell distribution width (RDW), haemoglobin, serum iron, serum ferritin, serum transferrin, transferrin saturation, soluble transferrin receptor (sTfR-2), and zinc protoporphyrin (ZnPP). The fruit juices consumption involved increased intake of carbohydrates and vitamin C, and increased body mass index within normal limits. Ferritin was higher in F after week 4 (p<0•05) and became 80% higher than in P after week 16 (p<0•001), and transferrin decreased in F group compared to P group after week 4 (p<0•001). RDW was higher at weeks 4 and 8 in F compared to P (p<0•05). Transferrin saturation increased after week 8, and haematocrit, MCV, and haemoglobin increased after week 12, in F compared to P. Serum iron did not change. sTfR and ZnPP decreased in F at week 16 (p<0•05). Iron pyrophosphate fortified fruit juice improves iron status and may be used to prevent iron deficiency anaemia. This trial was register at clinicaltrials.gov as NCT01135576. Supported by Grupo Leche Pascual and Projects Ref. AGL2006 09519/ALI and Ref. AGL2009 11437. Peer reviewed 2011-02-25T09:28:54Z 2011-02-25T09:28:54Z 2011-02-25 artículo http://purl.org/coar/resource_type/c_6501 British Journal of Nutrition 105(11) : 1652-1659 (2011) http://hdl.handle.net/10261/32822 10.1017/S0007114510005490 en 10.1017/S0007114510005490 open |
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Fortification Ferric pyrophosphate iron-deficiency anaemia iron status women Fortification Ferric pyrophosphate iron-deficiency anaemia iron status women |
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Fortification Ferric pyrophosphate iron-deficiency anaemia iron status women Fortification Ferric pyrophosphate iron-deficiency anaemia iron status women Blanco Rojo, R. Pérez Granados, Ana M. Toxqui, Laura González-Vizcayno, Carmen Delgado, Marco A. Vaquero, M. Pilar Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women |
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Iron deficiency anaemia is a worldwide health problem. We studied the influence of consuming an iron fortified fruit juice on iron status in menstruating women.
A randomised double-blind placebo-controlled study of 16-weeks of duration was performed. Two groups: P group (n=58) or F group (n=64) consumed, as a supplement to their usual diet, 500 mL/day of placebo fruit juice or iron-fortified fruit juice, respectively. The iron fortified-juice, containing microencapsulated iron pyrophosphate, provided 18 mg of iron (100% of the recommended dietary allowance per day). At baseline and monthly, dietary intake, body weight, and iron parameters were determined: total red blood cells, haematocrit, mean corpuscular volume (MCV), red blood cell distribution width (RDW), haemoglobin, serum iron, serum ferritin, serum transferrin, transferrin saturation, soluble transferrin receptor (sTfR-2), and zinc protoporphyrin (ZnPP). The fruit juices consumption involved increased intake of carbohydrates and vitamin C, and increased body mass index within normal limits. Ferritin was higher in F after week 4 (p<0•05) and became 80% higher than in P after week 16 (p<0•001), and transferrin decreased in F group compared to P group after week 4 (p<0•001). RDW was higher at weeks 4 and 8 in F compared to P (p<0•05). Transferrin saturation increased after week 8, and haematocrit, MCV, and haemoglobin increased after week 12, in F compared to P. Serum iron did not change. sTfR and ZnPP decreased in F at week 16 (p<0•05). Iron pyrophosphate fortified fruit juice improves iron status and may be used to prevent iron deficiency anaemia. This trial was register at clinicaltrials.gov as NCT01135576. |
format |
artículo |
topic_facet |
Fortification Ferric pyrophosphate iron-deficiency anaemia iron status women |
author |
Blanco Rojo, R. Pérez Granados, Ana M. Toxqui, Laura González-Vizcayno, Carmen Delgado, Marco A. Vaquero, M. Pilar |
author_facet |
Blanco Rojo, R. Pérez Granados, Ana M. Toxqui, Laura González-Vizcayno, Carmen Delgado, Marco A. Vaquero, M. Pilar |
author_sort |
Blanco Rojo, R. |
title |
Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women |
title_short |
Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women |
title_full |
Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women |
title_fullStr |
Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women |
title_full_unstemmed |
Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women |
title_sort |
efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in spanish iron-deficient women |
publishDate |
2011-02-25 |
url |
http://hdl.handle.net/10261/32822 |
work_keys_str_mv |
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