2-OHOA supplementation reduced adiposity and improved cardiometabolic risk to a greater extent than n-3 PUFA in obese mice

Redondo, Noemí; Gheorghe, Alina; Pérez de Heredia, F.; Díaz, L. E.; Baccan, G. C.; De la Fuente, Mónica; Marcos, Ascensión; Ministerio de Ciencia e Innovación (España)

2-OHOA supplementation reduced adiposity and improved cardiometabolic risk to a greater extent than n-3 PUFA in obese mice

[Objective]: We aimed to assess whether 2-hydroxyoleic acid (2-OHOA) and n-3 polyunsaturated fatty acids (PUFA) could counteract changes on adipokine secretion and cardiometabolic risk biomarkers associated with high-fat diet-induced obesity in mice.

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Main Authors:	Redondo, Noemí, Gheorghe, Alina, Pérez de Heredia, F., Díaz, L. E., Baccan, G. C., De la Fuente, Mónica, Marcos, Ascensión
Other Authors:	Ministerio de Ciencia e Innovación (España)
Format:	artículo biblioteca
Language:	English
Published:	Elsevier 2019
Online Access:	http://hdl.handle.net/10261/203185 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100004587 http://dx.doi.org/10.13039/501100000780
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spelling	dig-ictan-es-10261-2031852020-04-07T01:13:00Z 2-OHOA supplementation reduced adiposity and improved cardiometabolic risk to a greater extent than n-3 PUFA in obese mice Redondo, Noemí Gheorghe, Alina Pérez de Heredia, F. Díaz, L. E. Baccan, G. C. De la Fuente, Mónica Marcos, Ascensión Ministerio de Ciencia e Innovación (España) Ministerio de Economía y Competitividad (España) Instituto de Salud Carlos III European Commission [Objective]: We aimed to assess whether 2-hydroxyoleic acid (2-OHOA) and n-3 polyunsaturated fatty acids (PUFA) could counteract changes on adipokine secretion and cardiometabolic risk biomarkers associated with high-fat diet-induced obesity in mice. [Methods]: Female ICR/CD1 mice (8 weeks old) were divided into four groups receiving different diets (n = 8/group): (1) standard chow (control) for 18 weeks; (2) 22% fat for 4 weeks + 60% fat for 14 weeks (obesogenic diet, OD); 3) OD + 2-OHOA (1500 mg kg−1 diet) for the last 6 weeks (ODHO); and 4) OD + n-3 PUFA (eicosapentaenoic + docosahexaenoic acids, 1500 + 1500 mg kg−1 diet) for the last 6 weeks (OD-N3). After 18 weeks, body weight, periovarian visceral fat, heart and liver weights were measured, as well as cardiometabolic parameters (systolic and diastolic blood pressure, blood glucose, insulin, HOMA index, triglycerides, total cholesterol, apolipoproteins A1 and E), plasma adipokines and inflammatory proteins (leptin, adiponectin, plasminogen activator inhibitor 1 [PAI1], soluble E-selectin [sE-selectin], matrix metalloproteinase-9 [MMP-9], fibrinogen, soluble intercellular adhesion molecule [sICAM] and soluble vascular adhesion molecule [sVCAM]), and secretion of pro-inflamatory cytokines and inflammatory biomarkers from periovarian adipocytes. [Results]: OD mice had greater body and heart weights, and plasma leptin, and lower adiponectin and resistin secretion from adipocytes. Supplementation with 2-OHOA reduced body and heart weights, blood pressure, triglycerides and leptin, and restored adiponectin and resistin secretion, while n-3 PUFA only reduced triglyceride levels (all P < 0.05). [Conclusion]: 2-OHOA supplementation was more effective in reducing adiposity, modulating adipokine secretion and ameliorating cardiometabolic risk than n-3 PUFA. The work was partially funded by BTSA-Applied Biotechnologies S.L., which was the manufacturer of the fatty acid supplements. This funding was not provided directly to the authors; it occurred in the context of a larger consortium co-ordinated by the CENIT (National Strategic Consortia for Technical Research) Program, the Spanish Ministry of Economy and Competitiveness (MICINN; BFU2011-3036), the Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad (RETICEF) (RD12/0043/0018) and Fondo de Investigaciones Sanitarias (FIS) (PI15/01787) from the Carlos III Health Institute (ISCIII)-Fondo Europeo de Desarrollo Regional (FEDER) of the European Union and the PRONAOS Study (CDTI 20081114). Peer reviewed 2020-03-09T10:58:34Z 2020-03-09T10:58:34Z 2019 artículo http://purl.org/coar/resource_type/c_6501 Obesity Research and Clinical Practice 13(6): 579-585 (2019) 1871-403X http://hdl.handle.net/10261/203185 10.1016/j.orcp.2019.10.009 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100004587 http://dx.doi.org/10.13039/501100000780 en Preprint https://doi.org/10.1016/j.orcp.2019.10.009 Sí open Elsevier
institution	ICTAN ES
collection	DSpace
country	España
countrycode	ES
component	Bibliográfico
access	En linea
databasecode	dig-ictan-es
tag	biblioteca
region	Europa del Sur
libraryname	Biblioteca del ICTAN España
language	English
description	[Objective]: We aimed to assess whether 2-hydroxyoleic acid (2-OHOA) and n-3 polyunsaturated fatty acids (PUFA) could counteract changes on adipokine secretion and cardiometabolic risk biomarkers associated with high-fat diet-induced obesity in mice.
author2	Ministerio de Ciencia e Innovación (España)
author_facet	Ministerio de Ciencia e Innovación (España) Redondo, Noemí Gheorghe, Alina Pérez de Heredia, F. Díaz, L. E. Baccan, G. C. De la Fuente, Mónica Marcos, Ascensión
format	artículo
author	Redondo, Noemí Gheorghe, Alina Pérez de Heredia, F. Díaz, L. E. Baccan, G. C. De la Fuente, Mónica Marcos, Ascensión
spellingShingle	Redondo, Noemí Gheorghe, Alina Pérez de Heredia, F. Díaz, L. E. Baccan, G. C. De la Fuente, Mónica Marcos, Ascensión 2-OHOA supplementation reduced adiposity and improved cardiometabolic risk to a greater extent than n-3 PUFA in obese mice
author_sort	Redondo, Noemí
title	2-OHOA supplementation reduced adiposity and improved cardiometabolic risk to a greater extent than n-3 PUFA in obese mice
title_short	2-OHOA supplementation reduced adiposity and improved cardiometabolic risk to a greater extent than n-3 PUFA in obese mice
title_full	2-OHOA supplementation reduced adiposity and improved cardiometabolic risk to a greater extent than n-3 PUFA in obese mice
title_fullStr	2-OHOA supplementation reduced adiposity and improved cardiometabolic risk to a greater extent than n-3 PUFA in obese mice
title_full_unstemmed	2-OHOA supplementation reduced adiposity and improved cardiometabolic risk to a greater extent than n-3 PUFA in obese mice
title_sort	2-ohoa supplementation reduced adiposity and improved cardiometabolic risk to a greater extent than n-3 pufa in obese mice
publisher	Elsevier
publishDate	2019
url	http://hdl.handle.net/10261/203185 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100004587 http://dx.doi.org/10.13039/501100000780
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2-OHOA supplementation reduced adiposity and improved cardiometabolic risk to a greater extent than n-3 PUFA in obese mice

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