A Targeted Association Study of Immunity Genes and Networks Suggests Novel Associations with Placental Malaria Infection
Martin Sikora et al.
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2011-09-19
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| Online Access: | http://hdl.handle.net/10261/43752 http://dx.doi.org/10.13039/501100004587 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/100007406 http://dx.doi.org/10.13039/501100003767 http://dx.doi.org/10.13039/501100003751 |
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dig-ibe-es-10261-437522021-12-28T16:24:06Z A Targeted Association Study of Immunity Genes and Networks Suggests Novel Associations with Placental Malaria Infection Sikora, Martin Bertranpetit, Jaume Ministerio de Educación y Ciencia (España) Instituto de Salud Carlos III Generalitat de Catalunya Fundación BBVA Ministerio de Asuntos Exteriores y Cooperación (España) Instituto Nacional de Bioinformática (España) Netherlands Organization for Scientific Research Ministerio de Sanidad, Servicios Sociales e Igualdad (España) Martin Sikora et al. A large proportion of the death toll associated with malaria is a consequence of malaria infection during pregnancy, causing up to 200,000 infant deaths annually. We previously published the first extensive genetic association study of placental malaria infection, and here we extend this analysis considerably, investigating genetic variation in over 9,000 SNPs in more than 1,000 genes involved in immunity and inflammation for their involvement in susceptibility to placental malaria infection. We applied a new approach incorporating results from both single gene analysis as well as gene-gene interactions on a protein-protein interaction network. We found suggestive associations of variants in the gene KLRK1 in the single gene analysis, as well as evidence for associations of multiple members of the IL-7/IL-7R signalling cascade in the combined analysis. To our knowledge, this is the first large-scale genetic study on placental malaria infection to date, opening the door for follow-up studies trying to elucidate the genetic basis of this neglected form of malaria. This work was supported by grant SAF-2007-63171 awarded by Ministerio de Educación y Ciencia (Spain) to JB and the CIBERESP (CIBER of Epidemiology and Public Health, Ministry of Health). Funds were also obtained from Dirreció General de Recerca of Generalitat de Catalunya (Grup de Recerca Consolidat 2005SGR/00608) and from Banco de Bilbao, Vizcaya, Argentaria Foundation (grant number BBVA 02-0). The CISM receives core support from the Spanish Agency for International Cooperation and Development (AECID). All the genotyping was provided by the Spanish “Centro Nacional de Genotipado” (CEGEN; www.cegen.org); support for computations was provided by the National Institute for Bioinformatics (www.inab.org); both are platforms of Genoma España. MGN was supported by a Vici grant of the Netherlands Organization for Scientific Research. AM was supported by the Spanish Ministry of Health (Program for the Promotion of Biomedical Research and Health Sciences, Instituto de Salud Carlos III, CP-04/00220). MS was supported by a PhD fellowship from the Programa de becas FPU del Ministerio de Educación y Ciencia, Spain (AP2005-3982). Peer reviewed 2011-12-27T11:39:58Z 2011-12-27T11:39:58Z 2011-09-19 artículo http://purl.org/coar/resource_type/c_6501 PLoS ONE 6(9): e24996 (2011) 1932-6203 http://hdl.handle.net/10261/43752 10.1371/journal.pone.0024996 http://dx.doi.org/10.13039/501100004587 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/100007406 http://dx.doi.org/10.13039/501100003767 http://dx.doi.org/10.13039/501100003751 21949827 en Publisher’s version http://dx.doi.org/10.1371/journal.pone.0024996 Sí open Public Library of Science |
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Martin Sikora et al. |
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Ministerio de Educación y Ciencia (España) |
| author_facet |
Ministerio de Educación y Ciencia (España) Sikora, Martin Bertranpetit, Jaume |
| format |
artículo |
| author |
Sikora, Martin Bertranpetit, Jaume |
| spellingShingle |
Sikora, Martin Bertranpetit, Jaume A Targeted Association Study of Immunity Genes and Networks Suggests Novel Associations with Placental Malaria Infection |
| author_sort |
Sikora, Martin |
| title |
A Targeted Association Study of Immunity Genes and Networks Suggests Novel Associations with Placental Malaria Infection |
| title_short |
A Targeted Association Study of Immunity Genes and Networks Suggests Novel Associations with Placental Malaria Infection |
| title_full |
A Targeted Association Study of Immunity Genes and Networks Suggests Novel Associations with Placental Malaria Infection |
| title_fullStr |
A Targeted Association Study of Immunity Genes and Networks Suggests Novel Associations with Placental Malaria Infection |
| title_full_unstemmed |
A Targeted Association Study of Immunity Genes and Networks Suggests Novel Associations with Placental Malaria Infection |
| title_sort |
targeted association study of immunity genes and networks suggests novel associations with placental malaria infection |
| publisher |
Public Library of Science |
| publishDate |
2011-09-19 |
| url |
http://hdl.handle.net/10261/43752 http://dx.doi.org/10.13039/501100004587 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/100007406 http://dx.doi.org/10.13039/501100003767 http://dx.doi.org/10.13039/501100003751 |
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