A variant in the gene FUT9 is associated with susceptibility to placental malaria infection

A variant in the gene FUT9 is associated with susceptibility to placental malaria infection

9 páginas, 3 figuras, 3 tablas.-- et al.

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Main Authors: Sikora, Martin, Ferrer Admetlla, Anna, Laayouni, Hafid, Bertranpetit, Jaume, Casals, Ferran
Format: artículo biblioteca
Language:English
Published: Oxford University Press 2009
Online Access:http://hdl.handle.net/10261/43729
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spelling dig-ibe-es-10261-437292018-09-17T12:22:56Z A variant in the gene FUT9 is associated with susceptibility to placental malaria infection Sikora, Martin Ferrer Admetlla, Anna Laayouni, Hafid Bertranpetit, Jaume Casals, Ferran 9 páginas, 3 figuras, 3 tablas.-- et al. Malaria in pregnancy forms a substantial part of the worldwide burden of malaria, with an estimated annual death toll of up to 200 000 infants, as well as increased maternal morbidity and mortality. Studies of genetic susceptibility to malaria have so far focused on infant malaria, with only a few studies investigating the genetic basis of placental malaria, focusing only on a limited number of candidate genes. The aim of this study therefore was to identify novel host genetic factors involved in placental malaria infection. To this end we carried out a nested case–control study on 180 Mozambican pregnant women with placental malaria infection, and 180 controls within an intervention trial of malaria prevention. We genotyped 880 SNPs in a set of 64 functionally related genes involved in glycosylation and innate immunity. A single nucleotide polymorphism (SNP) located in the gene FUT9, rs3811070, was significantly associated with placental malaria infection (odds ratio = 2.31, permutation P-value=0.028). Haplotypic analysis revealed a similarly strong association of a common haplotype of four SNPs including rs3811070. FUT9 codes for a fucosyl-transferase that is catalyzing the last step in the biosynthesis of the Lewis-x antigen, which forms part of the Lewis blood group-related antigens. These results therefore suggest an involvement of this antigen in the pathogenesis of placental malaria infection. This work was supported by grant SAF-2007-63171 awarded by Ministerio de Educación y Ciencia (Spain) to J.B. and the CIBERESP (CIBER of Epidemiology and Public Health, Ministry of Health). Funds were also obtained from Direcció General de Recerca of Generalitat de Catalunya (Grup de Recerca Consolidat 2005SGR/00608) and from Banco de Bilbao, Vizcaya, Argentaria Foundation (grant number BBVA 02-0). The CISM receives core support from the Spanish Agency for International Cooperation and Development (AECID). A.M. was supported by the Spanish Ministry of Health (Program for the Promotion of Biomedical Research and Health Sciences, Instituto de Salud Carlos III, CP-04/00220). M.S. is supported by a PhD fellowship from the Programa de becas FPU del Ministerio de Educación y Ciencia, Spain (AP2005-3982). Peer reviewed 2011-12-27T08:10:14Z 2011-12-27T08:10:14Z 2009 artículo http://purl.org/coar/resource_type/c_6501 Human Molecular Genetics 18(16): 3163-3144 (2009) 0964-6906 http://hdl.handle.net/10261/43729 10.1093/hmg/ddp240 1460-2083 en http://dx.doi.org/10.1093/hmg/ddp240 none Oxford University Press
institution IBE ES
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country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-ibe-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IBE España
language English
description 9 páginas, 3 figuras, 3 tablas.-- et al.
format artículo
author Sikora, Martin
Ferrer Admetlla, Anna
Laayouni, Hafid
Bertranpetit, Jaume
Casals, Ferran
spellingShingle Sikora, Martin
Ferrer Admetlla, Anna
Laayouni, Hafid
Bertranpetit, Jaume
Casals, Ferran
A variant in the gene FUT9 is associated with susceptibility to placental malaria infection
author_facet Sikora, Martin
Ferrer Admetlla, Anna
Laayouni, Hafid
Bertranpetit, Jaume
Casals, Ferran
author_sort Sikora, Martin
title A variant in the gene FUT9 is associated with susceptibility to placental malaria infection
title_short A variant in the gene FUT9 is associated with susceptibility to placental malaria infection
title_full A variant in the gene FUT9 is associated with susceptibility to placental malaria infection
title_fullStr A variant in the gene FUT9 is associated with susceptibility to placental malaria infection
title_full_unstemmed A variant in the gene FUT9 is associated with susceptibility to placental malaria infection
title_sort variant in the gene fut9 is associated with susceptibility to placental malaria infection
publisher Oxford University Press
publishDate 2009
url http://hdl.handle.net/10261/43729
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