The place of metropolitan France in the European genomic landscape
Unlike other European countries, the human population genetics and demographic history of Metropolitan France is surprisingly understudied. In this work, we combined newly genotyped samples from various zones in France with publicly available data and applied both allele frequency and haplotype-based methods to describe the internal structure of this country, using genome-wide single nucleotide polymorphism (SNP) array genotypes. We found out that French Basques, already known for their linguistic uniqueness, are genetically distinct from all other groups and that the populations from southwest France (namely the Gascony region) share a large proportion of their ancestry with Basques. Otherwise, the genetic makeup of the French population is relatively homogeneous and mostly related to Southern and Central European groups. However, a fine-grained, haplotype-based analysis revealed that Bretons slightly separated from the rest of the groups, due mostly to gene flow from the British Isles in a time frame that coincides both historically attested Celtic population movements to this area between the 3th and the ninth centuries CE, but also with a more ancient genetic continuity between Brittany and the British Isles related to the shared drift with hunter-gatherer populations. Haplotype-based methods also unveiled subtle internal structures and connections with the surrounding modern populations, particularly in the periphery of the country.
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Springer Nature
2020-04-07
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Online Access: | http://hdl.handle.net/10261/218880 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100003030 http://dx.doi.org/10.13039/501100000780 |
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dig-ibe-es-10261-2188802021-10-04T10:10:33Z The place of metropolitan France in the European genomic landscape Biagini, Simone Andrea Ramos-Luis, Eva Comas, David Calafell, Francesc Ministerio de Economía y Competitividad (España) Agència de Gestió d'Ajuts Universitaris i de Recerca European Commission Agencia Estatal de Investigación (España) Unlike other European countries, the human population genetics and demographic history of Metropolitan France is surprisingly understudied. In this work, we combined newly genotyped samples from various zones in France with publicly available data and applied both allele frequency and haplotype-based methods to describe the internal structure of this country, using genome-wide single nucleotide polymorphism (SNP) array genotypes. We found out that French Basques, already known for their linguistic uniqueness, are genetically distinct from all other groups and that the populations from southwest France (namely the Gascony region) share a large proportion of their ancestry with Basques. Otherwise, the genetic makeup of the French population is relatively homogeneous and mostly related to Southern and Central European groups. However, a fine-grained, haplotype-based analysis revealed that Bretons slightly separated from the rest of the groups, due mostly to gene flow from the British Isles in a time frame that coincides both historically attested Celtic population movements to this area between the 3th and the ninth centuries CE, but also with a more ancient genetic continuity between Brittany and the British Isles related to the shared drift with hunter-gatherer populations. Haplotype-based methods also unveiled subtle internal structures and connections with the surrounding modern populations, particularly in the periphery of the country. Funding was provided by the Agencia Estatal de Investigación and Fondo Europeo de Desarollo Regional (FEDER) (grant CGL2016-75389-P), Agència de Gestió d’Ajuts Universitaris i de la Recerca (Generalitat de Catalunya) Grant 2014SGR2866, and “Unidad de Excelencia María de Maeztu”, funded by the MINECO (ref: MDM-2014–0370). SAB was supported by the Agencia Estatal de Investigación FPI grant BES-2014–069224. Peer reviewed 2020-08-31T10:01:31Z 2020-08-31T10:01:31Z 2020-04-07 artículo http://purl.org/coar/resource_type/c_6501 Human Genetics 139: 1091–1105 (2020) 0340-6717 http://hdl.handle.net/10261/218880 10.1007/s00439-020-02158-y 1432-1203 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100003030 http://dx.doi.org/10.13039/501100000780 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CGL2016-75389-P info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MDM-2014-0370 info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CGL2013-44351-P https://doi.org/10.1007/s00439-020-02158-y Sí none Springer Nature |
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Unlike other European countries, the human population genetics and demographic history of Metropolitan France is surprisingly understudied. In this work, we combined newly genotyped samples from various zones in France with publicly available data and applied both allele frequency and haplotype-based methods to describe the internal structure of this country, using genome-wide single nucleotide polymorphism (SNP) array genotypes. We found out that French Basques, already known for their linguistic uniqueness, are genetically distinct from all other groups and that the populations from southwest France (namely the Gascony region) share a large proportion of their ancestry with Basques. Otherwise, the genetic makeup of the French population is relatively homogeneous and mostly related to Southern and Central European groups. However, a fine-grained, haplotype-based analysis revealed that Bretons slightly separated from the rest of the groups, due mostly to gene flow from the British Isles in a time frame that coincides both historically attested Celtic population movements to this area between the 3th and the ninth centuries CE, but also with a more ancient genetic continuity between Brittany and the British Isles related to the shared drift with hunter-gatherer populations. Haplotype-based methods also unveiled subtle internal structures and connections with the surrounding modern populations, particularly in the periphery of the country. |
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Ministerio de Economía y Competitividad (España) |
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Ministerio de Economía y Competitividad (España) Biagini, Simone Andrea Ramos-Luis, Eva Comas, David Calafell, Francesc |
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Biagini, Simone Andrea Ramos-Luis, Eva Comas, David Calafell, Francesc |
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Biagini, Simone Andrea Ramos-Luis, Eva Comas, David Calafell, Francesc The place of metropolitan France in the European genomic landscape |
author_sort |
Biagini, Simone Andrea |
title |
The place of metropolitan France in the European genomic landscape |
title_short |
The place of metropolitan France in the European genomic landscape |
title_full |
The place of metropolitan France in the European genomic landscape |
title_fullStr |
The place of metropolitan France in the European genomic landscape |
title_full_unstemmed |
The place of metropolitan France in the European genomic landscape |
title_sort |
place of metropolitan france in the european genomic landscape |
publisher |
Springer Nature |
publishDate |
2020-04-07 |
url |
http://hdl.handle.net/10261/218880 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100003030 http://dx.doi.org/10.13039/501100000780 |
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