Is there adaptation in the human genome for taste perception and phase i biotransformation?
[Background] During the modern human expansion, new environmental pressures may have driven adaptation, especially in genes related to the perception of ingested substances and their detoxification. Consequently, positive (adaptive) selection may have occurred in genes related to taste, and in those related to the CYP450 system due to its role in biotransformation of potentially toxic compounds. A total of 91 genes (taste receptors and CYP450 superfamily) have been studied using Hierarchical Boosting, a powerful combination of different selection tests, to detect signatures of recent positive selection in three continental human populations: Northern Europeans (CEU), East Asians (CHB) and Africans (YRI). Analyses have been refined with selection analyses of the 26 populations of 1000 Genomes Project Phase 3.
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | artículo biblioteca |
| Published: |
BioMed Central
2019-01-31
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| Subjects: | Taste perception, Biotransformations, Cytochrome P450, Natural selection, CYP3A4, CYP3A43, CYP27A1, |
| Online Access: | http://hdl.handle.net/10261/206087 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100003176 http://dx.doi.org/10.13039/501100002809 |
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