S6 protein kinase activates Juvenile Hormone and vitellogenin production in the cockroach Blattella germanica

Nutritional status regulates different processes, such as growth and development, through TOR (target of rapamycin) and insulin receptor signalling pathways. The ribosomal S6 protein kinase (S6K) is a downstream element of both pathways. Using cDNA from the German cockroach Blattella germanica (L.), two S6K isoform sequences (BgS6K) are cloned. The long isoform differs from the short one by the insertion of a 22-amino acid duplication, involving the key phosphorylation position Thr390. As a result of this, the long isoform presents a new, potentially regulatory phosphorylation site. RNA interference knockdown of both BgS6K isoforms induces an increase in the length of the last nymphal instar, together with a reduction in the mRNA levels of a number of enzymes of the Juvenile Hormone biosynthetic pathway in the corpora allata, vitellogenin mRNA levels in the fat body and basal oocyte length. Thus, BgS6K is important for nymphal development and is necessary for the full induction of Juvenile Hormone synthesis and vitellogenin production in adult females.

Bibliographic Details

Main Authors:	Abrisqueta, Marc, Süren-Castillo, Songül, Maestro, José L.
Other Authors:	Ministerio de Ciencia e Innovación (España)
Format:	artículo biblioteca
Language:	English
Published:	John Wiley & Sons 2017-03
Subjects:	Blattella germanica, Insulin, juvenile hormone, Nutritional signalling, S6K, TOR, Vitellogenin,
Online Access:	http://hdl.handle.net/10261/148105 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100003339
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