Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children
25 pages, 2 figures, 2 tables.-- Provisional PDF.
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2010-02-24
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dig-iata-es-10261-224042021-12-27T16:39:45Z Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children Palma, Giada de Nadal, Inmaculada Medina, Marcela Susana Donat, Ester Ribes-Koninckx, Carmen Calabuig, Miguel Sanz Herranz, Yolanda 25 pages, 2 figures, 2 tables.-- Provisional PDF. [Background] Coeliac disease is a chronic intestinal inflammatory disorder caused by an aberrant immune response to dietary gluten proteins in genetically predisposed individuals. Mucosal immune response through IgA secretion constitutes a first line of defence responsible for neutralizing noxious antigens and pathogens. The aim of this study was the characterization of the relationships between immunoglobulin-coated bacteria and bacterial composition in faeces of coeliac disease (CD) patients, untreated and treated with a gluten-free diet (GFD) and healthy controls. [Results] IgA-coated faecal bacterial levels were significantly lower in both untreated and treated CD patients than in healthy controls. IgG and IgM-coated bacterial levels were also significantly lower in treated CD patients than in untreated CD patients and controls. Gram-positive to Gram-negative bacteria ratio was significantly reduced in both CD patients compared to controls. Bifidobacterium, Clostridium histolyticum, C. lituseburense and Faecalibacterium prausnitzii group proportions were less abundant (P<0.050) in untreated CD patients than in healthy controls. Bacteroides-Prevotella group proportions were more abundant (P<0.050) in untreated CD patients than in controls. Levels of IgA coating the Bacteroides-Prevotella group were significantly reduced (P<0.050) in both CD patients in comparison with healthy controls. [Conclusions] In CD patients, reduced IgA-coating bacteria is associated with intestinal dysbiosis, which altogether provide new insights into the possible relationships between the gut microbiota and the host defences in this disorder. This work was supported by grant AGL2007-66126-C03-01 and Consolider Fun-C-Food CSD2007-00063 from the Spanish Ministry of Science and Innovation (MICINN, Spain). The postdoctoral scholarship to M. Medina from MICINN, the scholarship to I. Nadal from Generalidad Valenciana (Spain) and CSIC (Ref 200570F0091), and to G. De Palma from CSIC are fully acknowledged. Peer reviewed 2010-03-15T14:51:26Z 2010-03-15T14:51:26Z 2010-02-24 artículo http://purl.org/coar/resource_type/c_6501 BMC Microbiology 10(63): (2010) 1471-2180 http://hdl.handle.net/10261/22404 10.1186/1471-2180-10-63 20181275 en Publisher’s version http://dx.doi.org/10.1186/1471-2180-10-63 open 223894 bytes application/pdf BioMed Central |
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España |
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ES |
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dig-iata-es |
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biblioteca |
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Biblioteca del IATA España |
| language |
English |
| description |
25 pages, 2 figures, 2 tables.-- Provisional PDF. |
| format |
artículo |
| author |
Palma, Giada de Nadal, Inmaculada Medina, Marcela Susana Donat, Ester Ribes-Koninckx, Carmen Calabuig, Miguel Sanz Herranz, Yolanda |
| spellingShingle |
Palma, Giada de Nadal, Inmaculada Medina, Marcela Susana Donat, Ester Ribes-Koninckx, Carmen Calabuig, Miguel Sanz Herranz, Yolanda Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children |
| author_facet |
Palma, Giada de Nadal, Inmaculada Medina, Marcela Susana Donat, Ester Ribes-Koninckx, Carmen Calabuig, Miguel Sanz Herranz, Yolanda |
| author_sort |
Palma, Giada de |
| title |
Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children |
| title_short |
Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children |
| title_full |
Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children |
| title_fullStr |
Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children |
| title_full_unstemmed |
Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children |
| title_sort |
intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children |
| publisher |
BioMed Central |
| publishDate |
2010-02-24 |
| url |
http://hdl.handle.net/10261/22404 |
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