Electrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulations
The design of novel delivery systems to treat vaginal fungal infections is a topic of high interest. Chitosan, being itself antimicrobial and having good mucoadhesive properties, is an excellent candidate as a delivery matrix for active compounds. In this work, chitosan microcapsules containing dry extracts of Argentinean medicinal plants with proved biological properties (Larrea divaricata, L. cuneifolia, L. nitida, Zuccagnia punctata and Tetraglochin andina) were developed through electrospraying and compared with conventionally used tablets containing the same extracts. Total phenolics, loading efficacy, physical properties, morphology and particle size, molecular organization, water sorption capacity, release of bioactive compounds and biological properties were assessed. The encapsulation process or the inclusion in tablets did not degrade the bioactive compounds of the extracts. The release of phenolic compounds from chitosan microcapsules was faster than from tablets. The fingerprint of released phenolic compounds from microcapsules and tablets was similar to that from the dry extracts and the antioxidant and antifungal capacity remained unchanged. The FT-IR analysis suggested interactions between the chitosan and the extracts, which explained why the microcapsules kept the integrity in slightly acidic media. Increased solubility of the extracts when incorporated in the microcapsules was seen in simulated vaginal fluid, potentially increasing the bioavailability of bioactive compounds in the vaginal environment.
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Format: | artículo biblioteca |
Language: | English |
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Elsevier
2018-08-22
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Subjects: | Anti-Candida, Argentinean dry plant extracts, Microcapsules, Vaginal tablets, |
Online Access: | http://hdl.handle.net/10261/171795 http://dx.doi.org/10.13039/501100003074 http://dx.doi.org/10.13039/501100007482 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100002923 http://dx.doi.org/10.13039/501100010599 |
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dig-iata-es-10261-1717952022-12-20T16:50:40Z Electrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulations Moreno, María Alejandra Gómez-Mascaraque, Laura G. Arias, Myriam Zampini, Iris Catiana Sayago, Jorge Esteban Pino Ramos, Leidy Liudis Schmeda-Hirschmann, Guillermo López-Rubio, Amparo Isla, María Inés Universidad Nacional de Tucumán Consejo Nacional de Investigaciones Científicas y Técnicas (Argentina) Agencia Nacional de Promoción Científica y Tecnológica (Argentina) Universidad de Talca Consejo Superior de Investigaciones Científicas (España) Anti-Candida Argentinean dry plant extracts Microcapsules Vaginal tablets The design of novel delivery systems to treat vaginal fungal infections is a topic of high interest. Chitosan, being itself antimicrobial and having good mucoadhesive properties, is an excellent candidate as a delivery matrix for active compounds. In this work, chitosan microcapsules containing dry extracts of Argentinean medicinal plants with proved biological properties (Larrea divaricata, L. cuneifolia, L. nitida, Zuccagnia punctata and Tetraglochin andina) were developed through electrospraying and compared with conventionally used tablets containing the same extracts. Total phenolics, loading efficacy, physical properties, morphology and particle size, molecular organization, water sorption capacity, release of bioactive compounds and biological properties were assessed. The encapsulation process or the inclusion in tablets did not degrade the bioactive compounds of the extracts. The release of phenolic compounds from chitosan microcapsules was faster than from tablets. The fingerprint of released phenolic compounds from microcapsules and tablets was similar to that from the dry extracts and the antioxidant and antifungal capacity remained unchanged. The FT-IR analysis suggested interactions between the chitosan and the extracts, which explained why the microcapsules kept the integrity in slightly acidic media. Increased solubility of the extracts when incorporated in the microcapsules was seen in simulated vaginal fluid, potentially increasing the bioavailability of bioactive compounds in the vaginal environment. This research was supported by grants from Secretaría de Ciencia, Arte e Innovación Tecnológica de la Universidad Nacional de Tucumán, Argentina (SCAIT-UNT), Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina (CONICET), Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT), Universidad de Talca, Chile (PIEI-QUIM-BIO) and EMHE-CSIC (Grant MHE-200038). L. G. Gómez-Mascaraque, is recipient of a predoctoral contract (BES-2013-065883) from the Spanish Ministry of Economy, Industry and Competitiveness (MINECO). The authors thank the Central Support Service for Experimental Research (SCSIE) of the University of Valencia for the electronic microscopy service. Peer reviewed 2018-11-02T07:50:49Z 2018-11-02T07:50:49Z 2018-08-22 artículo http://purl.org/coar/resource_type/c_6501 Carbohydrate Polymers 201: 425-437 (2018) 0144-8617 http://hdl.handle.net/10261/171795 10.1016/j.carbpol.2018.08.084 http://dx.doi.org/10.13039/501100003074 http://dx.doi.org/10.13039/501100007482 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100002923 http://dx.doi.org/10.13039/501100010599 en https://doi.org/10.1016/j.carbpol.2018.08.084 Sí open Elsevier |
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Anti-Candida Argentinean dry plant extracts Microcapsules Vaginal tablets Anti-Candida Argentinean dry plant extracts Microcapsules Vaginal tablets |
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Anti-Candida Argentinean dry plant extracts Microcapsules Vaginal tablets Anti-Candida Argentinean dry plant extracts Microcapsules Vaginal tablets Moreno, María Alejandra Gómez-Mascaraque, Laura G. Arias, Myriam Zampini, Iris Catiana Sayago, Jorge Esteban Pino Ramos, Leidy Liudis Schmeda-Hirschmann, Guillermo López-Rubio, Amparo Isla, María Inés Electrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulations |
description |
The design of novel delivery systems to treat vaginal fungal infections is a topic of high interest. Chitosan, being itself antimicrobial and having good mucoadhesive properties, is an excellent candidate as a delivery matrix for active compounds. In this work, chitosan microcapsules containing dry extracts of Argentinean medicinal plants with proved biological properties (Larrea divaricata, L. cuneifolia, L. nitida, Zuccagnia punctata and Tetraglochin andina) were developed through electrospraying and compared with conventionally used tablets containing the same extracts. Total phenolics, loading efficacy, physical properties, morphology and particle size, molecular organization, water sorption capacity, release of bioactive compounds and biological properties were assessed. The encapsulation process or the inclusion in tablets did not degrade the bioactive compounds of the extracts. The release of phenolic compounds from chitosan microcapsules was faster than from tablets. The fingerprint of released phenolic compounds from microcapsules and tablets was similar to that from the dry extracts and the antioxidant and antifungal capacity remained unchanged. The FT-IR analysis suggested interactions between the chitosan and the extracts, which explained why the microcapsules kept the integrity in slightly acidic media. Increased solubility of the extracts when incorporated in the microcapsules was seen in simulated vaginal fluid, potentially increasing the bioavailability of bioactive compounds in the vaginal environment. |
author2 |
Universidad Nacional de Tucumán |
author_facet |
Universidad Nacional de Tucumán Moreno, María Alejandra Gómez-Mascaraque, Laura G. Arias, Myriam Zampini, Iris Catiana Sayago, Jorge Esteban Pino Ramos, Leidy Liudis Schmeda-Hirschmann, Guillermo López-Rubio, Amparo Isla, María Inés |
format |
artículo |
topic_facet |
Anti-Candida Argentinean dry plant extracts Microcapsules Vaginal tablets |
author |
Moreno, María Alejandra Gómez-Mascaraque, Laura G. Arias, Myriam Zampini, Iris Catiana Sayago, Jorge Esteban Pino Ramos, Leidy Liudis Schmeda-Hirschmann, Guillermo López-Rubio, Amparo Isla, María Inés |
author_sort |
Moreno, María Alejandra |
title |
Electrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulations |
title_short |
Electrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulations |
title_full |
Electrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulations |
title_fullStr |
Electrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulations |
title_full_unstemmed |
Electrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulations |
title_sort |
electrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulations |
publisher |
Elsevier |
publishDate |
2018-08-22 |
url |
http://hdl.handle.net/10261/171795 http://dx.doi.org/10.13039/501100003074 http://dx.doi.org/10.13039/501100007482 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100002923 http://dx.doi.org/10.13039/501100010599 |
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