MERS-CoV in Arabian camels in Africa and Central Asia
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) causing infections in humans is genetically indistinguishable from the virus found in Arabian camels (dromedaries) in the Middle East. Although no primary human case of MERS was reported outside the Arabian Peninsula, camel populations in Africa are known to have high prevalence of antibodies against MERS-CoV. We carried out surveillance for MERS-CoV in dromedaries in Africa and Central Asia. By MERS-CoV spike pseudoparticle neutralization assay we confirmed that camel serum samples from African countries have high prevalence of MERS-CoV antibodies. Using RT-qPCR we detected MERS-CoV positives in camel nasal swabs from all different African countries from which samples were collected. However, dromedary serum and swab samples from Kazakhstan in Central Asia were negative for MERS-CoV by these assays. Phylogenetic analysis of the spike gene revealed that MERS-CoVs from Africa formed a cluster closely related to but distinct from the viruses from the Arabian Peninsula. Results from this study suggest that MERS-CoV is actively circulating in dromedary populations in Africa and the virus in Africa is phylogenetically distinct from that in the Middle East.
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dig-cirad-fr-5852412024-01-29T00:28:58Z http://agritrop.cirad.fr/585241/ http://agritrop.cirad.fr/585241/ MERS-CoV in Arabian camels in Africa and Central Asia. Chu Daniel K.W., Chan Samuel M.S., Perera Ranawaka A.P.M., Miguel Eve, Roger François, Chevalier Véronique, Poon Leo L.M., Peiris Malik. 2017. Virus Evolution, 3 (1), suppl. : S16-S17. International BioInformatics Workshop on Virus Evolution and Molecular Epidemiology. 21, Séoul, Corée du Sud, 14 Août 2016/19 Août 2016.https://doi.org/10.1093/ve/vew036.045 <https://doi.org/10.1093/ve/vew036.045> MERS-CoV in Arabian camels in Africa and Central Asia Chu, Daniel K.W. Chan, Samuel M.S. Perera, Ranawaka A.P.M. Miguel, Eve Roger, François Chevalier, Véronique Poon, Leo L.M. Peiris, Malik eng 2017 Oxford Academic Virus Evolution, Volume 3, Issue suppl_1 Virus Evolution L73 - Maladies des animaux 000 - Autres thèmes Orthocoronavirinae dromadaire genre humain surveillance épidémiologique génétique des populations phylogénie distribution géographique zoonose maladie de l'homme transmission des maladies http://aims.fao.org/aos/agrovoc/c_37003 http://aims.fao.org/aos/agrovoc/c_10467 http://aims.fao.org/aos/agrovoc/c_4586 http://aims.fao.org/aos/agrovoc/c_16411 http://aims.fao.org/aos/agrovoc/c_34326 http://aims.fao.org/aos/agrovoc/c_13325 http://aims.fao.org/aos/agrovoc/c_5083 http://aims.fao.org/aos/agrovoc/c_8530 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_2329 Afrique Asie centrale http://aims.fao.org/aos/agrovoc/c_165 http://aims.fao.org/aos/agrovoc/c_37864 Middle East Respiratory Syndrome Coronavirus (MERS-CoV) causing infections in humans is genetically indistinguishable from the virus found in Arabian camels (dromedaries) in the Middle East. Although no primary human case of MERS was reported outside the Arabian Peninsula, camel populations in Africa are known to have high prevalence of antibodies against MERS-CoV. We carried out surveillance for MERS-CoV in dromedaries in Africa and Central Asia. By MERS-CoV spike pseudoparticle neutralization assay we confirmed that camel serum samples from African countries have high prevalence of MERS-CoV antibodies. Using RT-qPCR we detected MERS-CoV positives in camel nasal swabs from all different African countries from which samples were collected. However, dromedary serum and swab samples from Kazakhstan in Central Asia were negative for MERS-CoV by these assays. Phylogenetic analysis of the spike gene revealed that MERS-CoVs from Africa formed a cluster closely related to but distinct from the viruses from the Arabian Peninsula. Results from this study suggest that MERS-CoV is actively circulating in dromedary populations in Africa and the virus in Africa is phylogenetically distinct from that in the Middle East. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/585241/1/vew036.045.pdf text Cirad license info:eu-repo/semantics/openAccess https://agritrop.cirad.fr/mention_legale.html https://doi.org/10.1093/ve/vew036.045 10.1093/ve/vew036.045 info:eu-repo/semantics/altIdentifier/doi/10.1093/ve/vew036.045 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1093/ve/vew036.045 |
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L73 - Maladies des animaux 000 - Autres thèmes Orthocoronavirinae dromadaire genre humain surveillance épidémiologique génétique des populations phylogénie distribution géographique zoonose maladie de l'homme transmission des maladies http://aims.fao.org/aos/agrovoc/c_37003 http://aims.fao.org/aos/agrovoc/c_10467 http://aims.fao.org/aos/agrovoc/c_4586 http://aims.fao.org/aos/agrovoc/c_16411 http://aims.fao.org/aos/agrovoc/c_34326 http://aims.fao.org/aos/agrovoc/c_13325 http://aims.fao.org/aos/agrovoc/c_5083 http://aims.fao.org/aos/agrovoc/c_8530 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_165 http://aims.fao.org/aos/agrovoc/c_37864 L73 - Maladies des animaux 000 - Autres thèmes Orthocoronavirinae dromadaire genre humain surveillance épidémiologique génétique des populations phylogénie distribution géographique zoonose maladie de l'homme transmission des maladies http://aims.fao.org/aos/agrovoc/c_37003 http://aims.fao.org/aos/agrovoc/c_10467 http://aims.fao.org/aos/agrovoc/c_4586 http://aims.fao.org/aos/agrovoc/c_16411 http://aims.fao.org/aos/agrovoc/c_34326 http://aims.fao.org/aos/agrovoc/c_13325 http://aims.fao.org/aos/agrovoc/c_5083 http://aims.fao.org/aos/agrovoc/c_8530 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_165 http://aims.fao.org/aos/agrovoc/c_37864 |
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L73 - Maladies des animaux 000 - Autres thèmes Orthocoronavirinae dromadaire genre humain surveillance épidémiologique génétique des populations phylogénie distribution géographique zoonose maladie de l'homme transmission des maladies http://aims.fao.org/aos/agrovoc/c_37003 http://aims.fao.org/aos/agrovoc/c_10467 http://aims.fao.org/aos/agrovoc/c_4586 http://aims.fao.org/aos/agrovoc/c_16411 http://aims.fao.org/aos/agrovoc/c_34326 http://aims.fao.org/aos/agrovoc/c_13325 http://aims.fao.org/aos/agrovoc/c_5083 http://aims.fao.org/aos/agrovoc/c_8530 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_165 http://aims.fao.org/aos/agrovoc/c_37864 L73 - Maladies des animaux 000 - Autres thèmes Orthocoronavirinae dromadaire genre humain surveillance épidémiologique génétique des populations phylogénie distribution géographique zoonose maladie de l'homme transmission des maladies http://aims.fao.org/aos/agrovoc/c_37003 http://aims.fao.org/aos/agrovoc/c_10467 http://aims.fao.org/aos/agrovoc/c_4586 http://aims.fao.org/aos/agrovoc/c_16411 http://aims.fao.org/aos/agrovoc/c_34326 http://aims.fao.org/aos/agrovoc/c_13325 http://aims.fao.org/aos/agrovoc/c_5083 http://aims.fao.org/aos/agrovoc/c_8530 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_165 http://aims.fao.org/aos/agrovoc/c_37864 Chu, Daniel K.W. Chan, Samuel M.S. Perera, Ranawaka A.P.M. Miguel, Eve Roger, François Chevalier, Véronique Poon, Leo L.M. Peiris, Malik MERS-CoV in Arabian camels in Africa and Central Asia |
description |
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) causing infections in humans is genetically indistinguishable from the virus found in Arabian camels (dromedaries) in the Middle East. Although no primary human case of MERS was reported outside the Arabian Peninsula, camel populations in Africa are known to have high prevalence of antibodies against MERS-CoV. We carried out surveillance for MERS-CoV in dromedaries in Africa and Central Asia. By MERS-CoV spike pseudoparticle neutralization assay we confirmed that camel serum samples from African countries have high prevalence of MERS-CoV antibodies. Using RT-qPCR we detected MERS-CoV positives in camel nasal swabs from all different African countries from which samples were collected. However, dromedary serum and swab samples from Kazakhstan in Central Asia were negative for MERS-CoV by these assays. Phylogenetic analysis of the spike gene revealed that MERS-CoVs from Africa formed a cluster closely related to but distinct from the viruses from the Arabian Peninsula. Results from this study suggest that MERS-CoV is actively circulating in dromedary populations in Africa and the virus in Africa is phylogenetically distinct from that in the Middle East. |
format |
article |
topic_facet |
L73 - Maladies des animaux 000 - Autres thèmes Orthocoronavirinae dromadaire genre humain surveillance épidémiologique génétique des populations phylogénie distribution géographique zoonose maladie de l'homme transmission des maladies http://aims.fao.org/aos/agrovoc/c_37003 http://aims.fao.org/aos/agrovoc/c_10467 http://aims.fao.org/aos/agrovoc/c_4586 http://aims.fao.org/aos/agrovoc/c_16411 http://aims.fao.org/aos/agrovoc/c_34326 http://aims.fao.org/aos/agrovoc/c_13325 http://aims.fao.org/aos/agrovoc/c_5083 http://aims.fao.org/aos/agrovoc/c_8530 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_165 http://aims.fao.org/aos/agrovoc/c_37864 |
author |
Chu, Daniel K.W. Chan, Samuel M.S. Perera, Ranawaka A.P.M. Miguel, Eve Roger, François Chevalier, Véronique Poon, Leo L.M. Peiris, Malik |
author_facet |
Chu, Daniel K.W. Chan, Samuel M.S. Perera, Ranawaka A.P.M. Miguel, Eve Roger, François Chevalier, Véronique Poon, Leo L.M. Peiris, Malik |
author_sort |
Chu, Daniel K.W. |
title |
MERS-CoV in Arabian camels in Africa and Central Asia |
title_short |
MERS-CoV in Arabian camels in Africa and Central Asia |
title_full |
MERS-CoV in Arabian camels in Africa and Central Asia |
title_fullStr |
MERS-CoV in Arabian camels in Africa and Central Asia |
title_full_unstemmed |
MERS-CoV in Arabian camels in Africa and Central Asia |
title_sort |
mers-cov in arabian camels in africa and central asia |
publisher |
Oxford Academic |
url |
http://agritrop.cirad.fr/585241/ http://agritrop.cirad.fr/585241/1/vew036.045.pdf |
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1792499331620667392 |