MBT/Pas mouse: A relevant model for the evaluation of Rift Valley fever vaccines

Currently, there are no worldwide licensed vaccines for Rift Valley fever (RVF) that are both safe and effective. Development and evaluation of vaccines, diagnostics and treatments depend on the availability of appropriate animal models. Animal models are also necessary to understand the basic pathobiology of infection. Here, we report the use of an inbred MBT/Pas mouse model that consistently reproduces RVF disease and serves our purpose for testing the efficacy of vaccine candidates; an attenuated Rift Valley fever virus (RVFV) and a recombinant RVFV-capripoxvirus. We show that this model is relevant for vaccine testing.

Bibliographic Details

Main Authors:	Ayari-Fakhfakh, Saïda Emna, Zaverucha do Valle, Tânia, Guillemot, Laurent, Panthier, Jean-Jacques, Bouloy, Michèle, Ghram, Abdeljelil, Albina, Emmanuel, Cetre-Sossah, Catherine
Format:	article biblioteca
Language:	eng
Subjects:	L73 - Maladies des animaux, Virus de la fièvre de la vallée du Rift, contrôle de maladies, souris, modèle, vaccin vivant, vaccin, efficacité, testage, fièvre de la Vallée du Rift, http://aims.fao.org/aos/agrovoc/c_16463, http://aims.fao.org/aos/agrovoc/c_2327, http://aims.fao.org/aos/agrovoc/c_4795, http://aims.fao.org/aos/agrovoc/c_4881, http://aims.fao.org/aos/agrovoc/c_24554, http://aims.fao.org/aos/agrovoc/c_8130, http://aims.fao.org/aos/agrovoc/c_2491, http://aims.fao.org/aos/agrovoc/c_7683, http://aims.fao.org/aos/agrovoc/c_b08d44fd, http://aims.fao.org/aos/agrovoc/c_8007,
Online Access:	http://agritrop.cirad.fr/572697/ http://agritrop.cirad.fr/572697/1/document_572697.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!