Apoptotic and cell cycle effects of triterpenes isolated from Phoradendron wattii on leukemia cell lines
Current antineoplastic agents present multiple disadvantages, driving an ongoing search for new and better compounds. Four lupane-type triterpenes, 3α,24-dihydroxylup-20(29)-en-28-oic acid (1), 3α,23-dihydroxy-30-oxo-lup-20(29)-en-28-oic acid (2), 3α,23-O-isopropylidenyl-3α,23-dihydroxylup-20(29)-en-28-oic acid (3), and 3α,23-dihydroxylup-20(29)-en-28-oic acid (4), previously isolated from Phoradendron wattii, were evaluated on two cell lines of chronic (K562) and acute (HL60) myeloid leukemia. Compounds 1, 2, and 4 decreased cell viability and inhibit proliferation, mainly in K562, and exhibited an apoptotic effect from 24 h of treatment. Of particular interest is compound 2, which caused arrest in active phases (G2/M) of the cell cycle, as shown by in silico study of the CDK1/Cyclin B/Csk2 complex by molecular docking. This compound [3α,23-dihydroxy-30-oxo-lup-20(29)-en-28-oic acid] s a promising candidate for incorporation into cancer treatments and deserves further study. © 2022 by the authors.
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| Subjects: | info:eu-repo/classification/Autores/LEUKEMIA, info:eu-repo/classification/Autores/LUPANE-TYPE TRITERPENE, info:eu-repo/classification/Autores/APOPTOSIS, info:eu-repo/classification/Autores/CELL CYCLE, info:eu-repo/classification/Autores/MOLECULAR DOCKING, info:eu-repo/classification/cti/2, info:eu-repo/classification/cti/24, info:eu-repo/classification/cti/2403, info:eu-repo/classification/cti/230221, |
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dig-cicy-1003-22572023-05-11T17:35:38Z Apoptotic and cell cycle effects of triterpenes isolated from Phoradendron wattii on leukemia cell lines LIA SARAHI VALENCIA CHAN Dafné Linda Moreno Lorenzana JIMMY JOSUE CEBALLOS CRUZ SERGIO RUBEN PERAZA SANCHEZ ANTONIETA CHAVEZ-GONZALEZ ROSA MOO_PUC 2022 info:eu-repo/semantics/article Current antineoplastic agents present multiple disadvantages, driving an ongoing search for new and better compounds. Four lupane-type triterpenes, 3α,24-dihydroxylup-20(29)-en-28-oic acid (1), 3α,23-dihydroxy-30-oxo-lup-20(29)-en-28-oic acid (2), 3α,23-O-isopropylidenyl-3α,23-dihydroxylup-20(29)-en-28-oic acid (3), and 3α,23-dihydroxylup-20(29)-en-28-oic acid (4), previously isolated from Phoradendron wattii, were evaluated on two cell lines of chronic (K562) and acute (HL60) myeloid leukemia. Compounds 1, 2, and 4 decreased cell viability and inhibit proliferation, mainly in K562, and exhibited an apoptotic effect from 24 h of treatment. Of particular interest is compound 2, which caused arrest in active phases (G2/M) of the cell cycle, as shown by in silico study of the CDK1/Cyclin B/Csk2 complex by molecular docking. This compound [3α,23-dihydroxy-30-oxo-lup-20(29)-en-28-oic acid] s a promising candidate for incorporation into cancer treatments and deserves further study. © 2022 by the authors. info:eu-repo/classification/Autores/LEUKEMIA info:eu-repo/classification/Autores/LUPANE-TYPE TRITERPENE info:eu-repo/classification/Autores/APOPTOSIS info:eu-repo/classification/Autores/CELL CYCLE info:eu-repo/classification/Autores/MOLECULAR DOCKING info:eu-repo/classification/cti/2 info:eu-repo/classification/cti/24 info:eu-repo/classification/cti/2403 info:eu-repo/classification/cti/230221 info:eu-repo/classification/cti/230221 Molecules, 27(17), 5616, 2022. http://cicy.repositorioinstitucional.mx/jspui/handle/1003/2257 info:eu-repo/semantics/openAccess eng info:eu-repo/semantics/reference/DOI/DOI: 10.3390/molecules27175616 citation:Valencia-Chan, L.S.; Moreno-Lorenzana, D.; Ceballos-Cruz, J.J.; Peraza-Sánchez, S.R.; Chávez-González, A.; Moo-Puc, R.E. Apoptotic and Cell Cycle Effects of Triterpenes Isolated from Phoradendron wattii on Leukemia Cell Lines. Molecules 2022, 27, 5616. https://doi.org/10.3390/molecules27175616 http://creativecommons.org/licenses/by-nc-nd/4.0 info:eu-repo/semantics/publishedVersion application/pdf |
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info:eu-repo/classification/Autores/LEUKEMIA info:eu-repo/classification/Autores/LUPANE-TYPE TRITERPENE info:eu-repo/classification/Autores/APOPTOSIS info:eu-repo/classification/Autores/CELL CYCLE info:eu-repo/classification/Autores/MOLECULAR DOCKING info:eu-repo/classification/cti/2 info:eu-repo/classification/cti/24 info:eu-repo/classification/cti/2403 info:eu-repo/classification/cti/230221 info:eu-repo/classification/cti/230221 info:eu-repo/classification/Autores/LEUKEMIA info:eu-repo/classification/Autores/LUPANE-TYPE TRITERPENE info:eu-repo/classification/Autores/APOPTOSIS info:eu-repo/classification/Autores/CELL CYCLE info:eu-repo/classification/Autores/MOLECULAR DOCKING info:eu-repo/classification/cti/2 info:eu-repo/classification/cti/24 info:eu-repo/classification/cti/2403 info:eu-repo/classification/cti/230221 info:eu-repo/classification/cti/230221 |
| spellingShingle |
info:eu-repo/classification/Autores/LEUKEMIA info:eu-repo/classification/Autores/LUPANE-TYPE TRITERPENE info:eu-repo/classification/Autores/APOPTOSIS info:eu-repo/classification/Autores/CELL CYCLE info:eu-repo/classification/Autores/MOLECULAR DOCKING info:eu-repo/classification/cti/2 info:eu-repo/classification/cti/24 info:eu-repo/classification/cti/2403 info:eu-repo/classification/cti/230221 info:eu-repo/classification/cti/230221 info:eu-repo/classification/Autores/LEUKEMIA info:eu-repo/classification/Autores/LUPANE-TYPE TRITERPENE info:eu-repo/classification/Autores/APOPTOSIS info:eu-repo/classification/Autores/CELL CYCLE info:eu-repo/classification/Autores/MOLECULAR DOCKING info:eu-repo/classification/cti/2 info:eu-repo/classification/cti/24 info:eu-repo/classification/cti/2403 info:eu-repo/classification/cti/230221 info:eu-repo/classification/cti/230221 LIA SARAHI VALENCIA CHAN Dafné Linda Moreno Lorenzana JIMMY JOSUE CEBALLOS CRUZ SERGIO RUBEN PERAZA SANCHEZ ANTONIETA CHAVEZ-GONZALEZ ROSA MOO_PUC Apoptotic and cell cycle effects of triterpenes isolated from Phoradendron wattii on leukemia cell lines |
| description |
Current antineoplastic agents present multiple disadvantages, driving an ongoing search for new and better compounds. Four lupane-type triterpenes, 3α,24-dihydroxylup-20(29)-en-28-oic acid (1), 3α,23-dihydroxy-30-oxo-lup-20(29)-en-28-oic acid (2), 3α,23-O-isopropylidenyl-3α,23-dihydroxylup-20(29)-en-28-oic acid (3), and 3α,23-dihydroxylup-20(29)-en-28-oic acid (4), previously isolated from Phoradendron wattii, were evaluated on two cell lines of chronic (K562) and acute (HL60) myeloid leukemia. Compounds 1, 2, and 4 decreased cell viability and inhibit proliferation, mainly in K562, and exhibited an apoptotic effect from 24 h of treatment. Of particular interest is compound 2, which caused arrest in active phases (G2/M) of the cell cycle, as shown by in silico study of the CDK1/Cyclin B/Csk2 complex by molecular docking. This compound [3α,23-dihydroxy-30-oxo-lup-20(29)-en-28-oic acid] s a promising candidate for incorporation into cancer treatments and deserves further study. © 2022 by the authors. |
| format |
info:eu-repo/semantics/article |
| topic_facet |
info:eu-repo/classification/Autores/LEUKEMIA info:eu-repo/classification/Autores/LUPANE-TYPE TRITERPENE info:eu-repo/classification/Autores/APOPTOSIS info:eu-repo/classification/Autores/CELL CYCLE info:eu-repo/classification/Autores/MOLECULAR DOCKING info:eu-repo/classification/cti/2 info:eu-repo/classification/cti/24 info:eu-repo/classification/cti/2403 info:eu-repo/classification/cti/230221 info:eu-repo/classification/cti/230221 |
| author |
LIA SARAHI VALENCIA CHAN Dafné Linda Moreno Lorenzana JIMMY JOSUE CEBALLOS CRUZ SERGIO RUBEN PERAZA SANCHEZ ANTONIETA CHAVEZ-GONZALEZ ROSA MOO_PUC |
| author_facet |
LIA SARAHI VALENCIA CHAN Dafné Linda Moreno Lorenzana JIMMY JOSUE CEBALLOS CRUZ SERGIO RUBEN PERAZA SANCHEZ ANTONIETA CHAVEZ-GONZALEZ ROSA MOO_PUC |
| author_sort |
LIA SARAHI VALENCIA CHAN |
| title |
Apoptotic and cell cycle effects of triterpenes isolated from Phoradendron wattii on leukemia cell lines |
| title_short |
Apoptotic and cell cycle effects of triterpenes isolated from Phoradendron wattii on leukemia cell lines |
| title_full |
Apoptotic and cell cycle effects of triterpenes isolated from Phoradendron wattii on leukemia cell lines |
| title_fullStr |
Apoptotic and cell cycle effects of triterpenes isolated from Phoradendron wattii on leukemia cell lines |
| title_full_unstemmed |
Apoptotic and cell cycle effects of triterpenes isolated from Phoradendron wattii on leukemia cell lines |
| title_sort |
apoptotic and cell cycle effects of triterpenes isolated from phoradendron wattii on leukemia cell lines |
| url |
http://cicy.repositorioinstitucional.mx/jspui/handle/1003/2257 |
| work_keys_str_mv |
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| _version_ |
1765903417043058688 |