Maternal and neonatal factors modulating breast milk cytokines in the first month of lactation

Maternal and neonatal factors modulating breast milk cytokines in the first month of lactation

This article belongs to the Special Issue Role of Oxidative Stress and Inflammation in Maternal-Perinatal Well-Being.

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Main Authors: Ramiro-Cortijo, David, Herranz Carrillo, Gloria, Singh, Pratibha, Rebollo-Hernanz, Miguel, Rodríguez-Rodríguez, Pilar, Ruvira, Santiago, Martín-Trueba, María, Martin, Camilia R., Arribas, Silvia M.
Other Authors: Ministerio de Igualdad (España)
Format: artículo biblioteca
Language:English
Published: Multidisciplinary Digital Publishing Institute 2023
Subjects:Cytokines, Breast milk, Neonatal adverse outcome, Sex, Inflammatory diet, Total antioxidant capacity, Prematurity, Lipid peroxidation,
Online Access:http://hdl.handle.net/10261/334103
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spelling dig-cial-es-10261-3341032023-08-30T06:37:35Z Maternal and neonatal factors modulating breast milk cytokines in the first month of lactation Ramiro-Cortijo, David Herranz Carrillo, Gloria Singh, Pratibha Rebollo-Hernanz, Miguel Rodríguez-Rodríguez, Pilar Ruvira, Santiago Martín-Trueba, María Martin, Camilia R. Arribas, Silvia M. Ministerio de Igualdad (España) Universidad Autónoma de Madrid Cytokines Breast milk Neonatal adverse outcome Sex Inflammatory diet Total antioxidant capacity Prematurity Lipid peroxidation This article belongs to the Special Issue Role of Oxidative Stress and Inflammation in Maternal-Perinatal Well-Being. Breast milk (BM) cytokines support and modulate infant immunity, being particularly relevant in premature neonates with adverse outcomes (NAO). This study aimed to examine, in a cohort of Spanish breastfeeding women, changes in BM cytokines in the first month of lactation, their modulation by neonatal factors (sex, gestational age, and NAO), maternal factors (obstetric complications, C-section, and diet), and their relationship with oxidative status. Sixty-three mother-neonate dyads were studied at days 7 and 28 of lactation. Dietary habits were assessed by a 72-h dietary recall, and the maternal dietary inflammatory index (mDII) was calculated. BM cytokines (IL-10, IL-13, IL-8, MCP-1, and TNFα) were assessed by ultra-sensitive chemiluminescence. Total antioxidant capacity was assessed by the ABTS method and lipid peroxidation by the MDA+HNE kit. From days 7 to 28 of lactation, the levels of IL-10 and TNFα remained stable, while IL-13 increased (β = 0.85 ± 0.12, p < 0.001) and IL-8 and MCP-1 levels decreased (β = −0.64 ± 0.27, p = 0.019; β = −0.98 ± 0.22, p < 0.001; respectively). Antioxidant capacity and lipid peroxidation also decrease during lactation. Neonatal sex did not influence any of the cytokines, but BM from mothers with male infants had a higher antioxidant capacity. Gestational age was associated with male sex and NAO, being inversely correlated with the BM proinflammatory cytokines IL-8, MCP-1, and TNFα. From days 7 to 28 of lactation, BM from women with NAO infants increased MCP-1 levels and had a larger drop in antioxidant capacity, with the opposite trend in lipid peroxidation. MCP-1 was also significantly higher in women undergoing C-section; this cytokine declined in women who decreased mDII during lactation, while IL-10 increased. Linear mixed regression models evidenced that the most important factors modulating BM cytokines were lactation period and gestational age. In conclusion, during the first month of lactation, BM cytokines shift towards an anti-inflammatory profile, influenced mainly by prematurity. BM MCP-1 is associated with maternal and neonatal inflammatory processes. This research was funded by the Instituto de las Mujeres, Ministerio de Igualdad (Spain), grant number PAC22-20/2ACT/22, and the Promotion of Knowledge Transfer Program (PTC-2020) from the Universidad Autónoma de Madrid (Spain). Peer reviewed 2023-08-30T06:37:34Z 2023-08-30T06:37:34Z 2023 artículo Antioxidants 12(5): 996 (2023) http://hdl.handle.net/10261/334103 10.3390/antiox12050996 2076-3921 37237863 en Publisher's version https://doi.org/10.3390/antiox12050996 Sí open application/pdf Multidisciplinary Digital Publishing Institute
institution CIAL ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-cial-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del CIAL España
language English
topic Cytokines
Breast milk
Neonatal adverse outcome
Sex
Inflammatory diet
Total antioxidant capacity
Prematurity
Lipid peroxidation
Cytokines
Breast milk
Neonatal adverse outcome
Sex
Inflammatory diet
Total antioxidant capacity
Prematurity
Lipid peroxidation
spellingShingle Cytokines
Breast milk
Neonatal adverse outcome
Sex
Inflammatory diet
Total antioxidant capacity
Prematurity
Lipid peroxidation
Cytokines
Breast milk
Neonatal adverse outcome
Sex
Inflammatory diet
Total antioxidant capacity
Prematurity
Lipid peroxidation
Ramiro-Cortijo, David
Herranz Carrillo, Gloria
Singh, Pratibha
Rebollo-Hernanz, Miguel
Rodríguez-Rodríguez, Pilar
Ruvira, Santiago
Martín-Trueba, María
Martin, Camilia R.
Arribas, Silvia M.
Maternal and neonatal factors modulating breast milk cytokines in the first month of lactation
description This article belongs to the Special Issue Role of Oxidative Stress and Inflammation in Maternal-Perinatal Well-Being.
author2 Ministerio de Igualdad (España)
author_facet Ministerio de Igualdad (España)
Ramiro-Cortijo, David
Herranz Carrillo, Gloria
Singh, Pratibha
Rebollo-Hernanz, Miguel
Rodríguez-Rodríguez, Pilar
Ruvira, Santiago
Martín-Trueba, María
Martin, Camilia R.
Arribas, Silvia M.
format artículo
topic_facet Cytokines
Breast milk
Neonatal adverse outcome
Sex
Inflammatory diet
Total antioxidant capacity
Prematurity
Lipid peroxidation
author Ramiro-Cortijo, David
Herranz Carrillo, Gloria
Singh, Pratibha
Rebollo-Hernanz, Miguel
Rodríguez-Rodríguez, Pilar
Ruvira, Santiago
Martín-Trueba, María
Martin, Camilia R.
Arribas, Silvia M.
author_sort Ramiro-Cortijo, David
title Maternal and neonatal factors modulating breast milk cytokines in the first month of lactation
title_short Maternal and neonatal factors modulating breast milk cytokines in the first month of lactation
title_full Maternal and neonatal factors modulating breast milk cytokines in the first month of lactation
title_fullStr Maternal and neonatal factors modulating breast milk cytokines in the first month of lactation
title_full_unstemmed Maternal and neonatal factors modulating breast milk cytokines in the first month of lactation
title_sort maternal and neonatal factors modulating breast milk cytokines in the first month of lactation
publisher Multidisciplinary Digital Publishing Institute
publishDate 2023
url http://hdl.handle.net/10261/334103
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