Egg white hydrolysate prevents reproductive impairments induced by cadmium in rats

Here, we investigated the ability of an egg white hydrolysate (EWH) to counteract the reproductive toxic effects induced by Cd in rats. 3-month-old male Wistar rats were treated for 14 days: (a) Untreated group (distilled water i.p.); (b) Cd group (CdCl2 at 1 mg/kg body weight i.p.); (c) EWH group (1 g/kg body weight/day per gavage); (d) CdEWH group (CdCl2 with EWH). Cd exposure was able to be accumulated in testis and epididymis, increasing oxidative stress and compromising sperm quality and daily sperm production. Co-treatment with EWH prevented increased deposition of Cd in testis (Untreated: 0.04 ± 0.02; Cd: 4.68 ± 1.03*; EWH: 0.01 ± 0.00; CdEWH: 1.85 ± 0.25# μg Cd/g dry tissue p < 0.05; *vs Untreated; #vs Cd), prevented reduction of sperm motility and the increased oxidative stress. Therefore, EWH could represent a powerful natural alternative to protect the male reproductive system against Cd-induced toxicity.

Bibliographic Details

Main Authors:	Gomes Pinheiro Júnior, José Eudes, Silveira Martinez, Caroline, Zambelli Moraes, Paola, Stasiaki, José Eduardo, Trost, Maria Elisa, Vassallo, Dalton Valentim, Barbosa Junior, Fernando, Peçanha, Franck Maciel, Weber Santos Cibin, Francielli, Miguel, Marta, Wiggers, Giulia Alessandra
Other Authors:	Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil)
Format:	artículo biblioteca
Language:	English
Published:	Elsevier 2020
Subjects:	Egg white hydrolysate, Reproductive system, Antioxidant, Oxidative stress, Cadmium,
Online Access:	http://hdl.handle.net/10261/238293 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100010598 http://dx.doi.org/10.13039/501100003593 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100002322
Tags:	Add Tag No Tags, Be the first to tag this record!