Intestinal signaling of proteins and digestion-derived products relevant to satiety
Luminal nutrients stimulate enteroendocrine cells through the activation of specific receptors to release hormones that inhibit appetite and promote glucose homeostasis. While food protein is the macronutrient with the highest effect on satiety, the signaling on the protein digestion products at the gut is poorly understood. This perspective aims to highlight the existing gaps in the study of protein digestion products as signaling molecules in gastrointestinal enteroendocrine cells. Because dietary protein digestion can be modulated by the technological processes applied to food, it is possible to target gut receptors to control food intake by formulating specific food ingredients or protein preloads.
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Format: | artículo biblioteca |
Language: | English |
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American Chemical Society
2018
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Subjects: | Enteroendocrine cells, Food proteins, Gastrointestinal digestion, Gastrointestinal hormones, |
Online Access: | http://hdl.handle.net/10261/192640 http://dx.doi.org/10.13039/501100003176 http://dx.doi.org/10.13039/501100003329 |
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dig-cial-es-10261-1926402019-10-16T01:11:53Z Intestinal signaling of proteins and digestion-derived products relevant to satiety Santos-Hernández, Marta Miralles, Beatriz Amigo, Lourdes Recio, Isidra Ministerio de Educación, Cultura y Deporte (España) Ministerio de Economía y Competitividad (España) Miralles, Beatriz [0000-0003-4544-9074] Recio, Isidra [0000-0003-2973-5329] Enteroendocrine cells Food proteins Gastrointestinal digestion Gastrointestinal hormones Luminal nutrients stimulate enteroendocrine cells through the activation of specific receptors to release hormones that inhibit appetite and promote glucose homeostasis. While food protein is the macronutrient with the highest effect on satiety, the signaling on the protein digestion products at the gut is poorly understood. This perspective aims to highlight the existing gaps in the study of protein digestion products as signaling molecules in gastrointestinal enteroendocrine cells. Because dietary protein digestion can be modulated by the technological processes applied to food, it is possible to target gut receptors to control food intake by formulating specific food ingredients or protein preloads. This work has received financial support from Project AGL2015-66886-R from the Spanish Ministry of Economy and Competitiveness (MINECO). Marta Santos-Hernandez is the recipient of a training of university teaching staff (FPU) grant (FPU15-03616) from the Ministry of Education, Culture and Sports. Peer reviewed 2019-10-15T08:32:26Z 2019-10-15T08:32:26Z 2018 artículo http://purl.org/coar/resource_type/c_6501 Journal of Agricultural and Food Chemistry 66(39): 10123-10131 (2018) 0021-8561 http://hdl.handle.net/10261/192640 10.1021/acs.jafc.8b02355 1520-5118 http://dx.doi.org/10.13039/501100003176 http://dx.doi.org/10.13039/501100003329 30056702 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-66886-R Publisher's version https://doi.org/10.1021/acs.jafc.8b02355 Sí open American Chemical Society |
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Enteroendocrine cells Food proteins Gastrointestinal digestion Gastrointestinal hormones Enteroendocrine cells Food proteins Gastrointestinal digestion Gastrointestinal hormones |
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Enteroendocrine cells Food proteins Gastrointestinal digestion Gastrointestinal hormones Enteroendocrine cells Food proteins Gastrointestinal digestion Gastrointestinal hormones Santos-Hernández, Marta Miralles, Beatriz Amigo, Lourdes Recio, Isidra Intestinal signaling of proteins and digestion-derived products relevant to satiety |
description |
Luminal nutrients stimulate enteroendocrine cells through the activation of specific receptors to release hormones that inhibit appetite and promote glucose homeostasis. While food protein is the macronutrient with the highest effect on satiety, the signaling on the protein digestion products at the gut is poorly understood. This perspective aims to highlight the existing gaps in the study of protein digestion products as signaling molecules in gastrointestinal enteroendocrine cells. Because dietary protein digestion can be modulated by the technological processes applied to food, it is possible to target gut receptors to control food intake by formulating specific food ingredients or protein preloads. |
author2 |
Ministerio de Educación, Cultura y Deporte (España) |
author_facet |
Ministerio de Educación, Cultura y Deporte (España) Santos-Hernández, Marta Miralles, Beatriz Amigo, Lourdes Recio, Isidra |
format |
artículo |
topic_facet |
Enteroendocrine cells Food proteins Gastrointestinal digestion Gastrointestinal hormones |
author |
Santos-Hernández, Marta Miralles, Beatriz Amigo, Lourdes Recio, Isidra |
author_sort |
Santos-Hernández, Marta |
title |
Intestinal signaling of proteins and digestion-derived products relevant to satiety |
title_short |
Intestinal signaling of proteins and digestion-derived products relevant to satiety |
title_full |
Intestinal signaling of proteins and digestion-derived products relevant to satiety |
title_fullStr |
Intestinal signaling of proteins and digestion-derived products relevant to satiety |
title_full_unstemmed |
Intestinal signaling of proteins and digestion-derived products relevant to satiety |
title_sort |
intestinal signaling of proteins and digestion-derived products relevant to satiety |
publisher |
American Chemical Society |
publishDate |
2018 |
url |
http://hdl.handle.net/10261/192640 http://dx.doi.org/10.13039/501100003176 http://dx.doi.org/10.13039/501100003329 |
work_keys_str_mv |
AT santoshernandezmarta intestinalsignalingofproteinsanddigestionderivedproductsrelevanttosatiety AT mirallesbeatriz intestinalsignalingofproteinsanddigestionderivedproductsrelevanttosatiety AT amigolourdes intestinalsignalingofproteinsanddigestionderivedproductsrelevanttosatiety AT recioisidra intestinalsignalingofproteinsanddigestionderivedproductsrelevanttosatiety |
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1777671338237886464 |