Nitric Oxide Research from Chemistry to Biology [electronic resource] /

Prologue -- Introducing the VIDM Club -- A Beautiful Molecule -- 1. Introduction: The Origins of Nitric Oxide -- Nitrogen Cycles -- Sources of Nitric Oxide, an Air Pollutant -- Use of Nitric Oxide as a Paramagnetic Probe of Metalloproteins -- Nitric Oxide in Bacterial Denitrification -- Effects of Exogenous Nitric Oxide on Humans -- Nitric Oxide Biosynthesis in Mammals -- Introductory Chapters -- Scaling Problems in the Quantification Methods of Nitric Oxide -- A Historical Note -- Additional Recent Bibliography -- 2. Basic Chemistry of Nitric Oxide and Related Nitrogen Oxides… -- Structure of Nitrogen Oxides -- Reactivity of Nitric Oxide and Nitrogen Oxides -- 3. Basic EPR Methodology -- Basic Principles of EPR Spectroscopy -- Experimental Conditions -- Discussion: Specificity Versus Sensitivity -- 4. EPR Characterization of Nitric Oxide Binding to Hemoglobin -- Nitrosyl Hemoglobin: Kinetic and EPR Data -- Reactions of Nitric Oxide with Ferrihemoglobin and Oxyhemoglobin -- Conclusion -- 5. Effects of Nitric Oxide on Red Blood Cells -- Effects of Long-Term Exposure of Animals and Humans to Nitric Oxide and Nitrogen Dioxide Gas Considered as Air Pollutants -- Effects of Nitrite and Nitrogenous Vasodilators on Red Blood Cells -- Effects on Red Blood Cells of Nitric Oxide Inhalation in Therapeutic Uses -- Conclusions -- 6. Utilization of Nitric Oxide as a Paramagnetic Probe of the Molecular Oxygen Binding Site of Metalloenzymes -- Hemoproteins -- Cytochrome c Oxidase (Cytochrome aa3) -- Copper-Containing Proteins -- Mononuclear Iron-Containing Dioxygenases -- [FeS], Ni and Mo Cluster-Containing Proteins -- Binuclear Iron-Containing Proteins -- Conclusion -- 7. Nitric Oxide, an Intermediate in the Denitrification Process and Other Bacterial Pathways, as Detected by EPR Spectroscopy -- Introduction: A Historical Background -- Respiratory and Assimilatory Nitrite Reductases -- Nitric Oxide Reductases -- Other Cytochromes Interacting with Nitric Oxide -- Nitrous Oxide Reductases -- Possible Roles of Nitric Oxide in Nitrification and Nitrogen-Fixation -- Bacterial Nitric Oxide Synthase -- Discussion and Conclusion -- 8. Nitric Oxide Biosynthesis in Mammals -- Constitutive and Inducible Nitric Oxide Synthases -- Enzymatic Mechanism of Nitric Oxide Synthases -- Nitric Oxide Synthases’ Regulations -- Post-Transcriptional Modifications of the Enzyme -- Conclusion -- 9. The Use of EPR Spectroscopy for the Identification of the Nature of Endothelium-Derived Relaxing Factor -- The Nature of Endothelium-Derived Relaxing Factor: A Controversy -- Nitric Oxide as an EDRF Detected by EPR Spectroscopy -- Fe(SR)2(NO)2 Ternary Iron Complexes as Plausible EDRF or Nitric Oxide Transporters -- Conclusion -- 10. Enzymatic Targets of Nitric Oxide as Detected by EPR Spectroscopy Within Mammal Cells -- Soluble Guanylate Cyclase -- [FeS] Cluster-Containing Enzyme -- Ribonucleotide Reductase -- Proteins of the Iron Metabolism -- Conclusion -- 11. Overproduction of Nitric Oxide in Physiology and Pathophysiology: EPR Detection -- Cancer and Interleukin-2 Immunotherapy -- Parasites, Fungi and Bacterial Infections -- Septic Shock -- Autoimmune Diseases -- Organ Transplantations -- Vascular Diseases -- Other Physiological and Pathophysiological States -- Conclusion -- 12. Palliatives to Underproduction of Nitric Oxide as Assayed by EPR Spectroscopy -- Metal Complexes as Nitric Oxide Donors -- Nitrite, Organic Nitrites and Nitrates -- Other Derivatives -- Inhalation Of Nitric Oxide: NO Gas, a Suppletive Drug -- Conclusion -- 13. Nitric Oxide-Specific Spin-Trapping EPR Methods -- Use of Hemoglobin as a Nitric Oxide Spin-Trap -- Conventional Spin-Trapping -- Prospects on Nitric Oxide-Specific Spin-Traps -- Scavenging of Nitric Oxide by Reaction with Stable Free Radicals -- Line Broadening of Fusinite and Other Free Radicals by Nitric Oxide -- Use of Fe-(DETC)2 and Similar Complexes as Nitric Oxide Spin-Traps -- Conclusion -- 14. General Discussion: Crossregulations of Metalloenzymes Triggered by Nitric Oxide -- Downregulation of Nitric Oxide Synthase by Nitric Oxide -- Inhibition of Microsomal Cytochromes P-450 -- The Urea Cycle -- Inhibition or Regulation of Cytochrome c Oxidase -- Crossregulations of Other Inducible Metalloproteins -- Regulation by Nitric Oxide of Other Metalloenzymes of the Inflammatory Response -- Other Targets -- General Conclusion.

Bibliographic Details

Main Authors:	Henry, Yann A. author., Guissani, Annie. author., Ducastel, Béatrice. author., SpringerLink (Online service)
Format:	Texto biblioteca
Language:	eng
Published:	Boston, MA : Springer US, 1997
Subjects:	Life sciences., Biochemistry., Cell biology., Life Sciences., Cell Biology., Biochemistry, general.,
Online Access:	http://dx.doi.org/10.1007/978-1-4613-1185-0
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