Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control [electronic resource] : Insights for Drug Discovery /
The localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules. Leukocyte Recruitment, Endothelial Cell Adhesion Molecules and Transcriptional Control: Insights for Drug Discovery outlines some of the cellular and molecular mechanisms of inflammation with contributions from top researchers. This volume provides an overview of three of these endothelial adhesion molecules, as examples of key mediators of leukocyte recruitment. It reviews the structure and regulation of these cell surface proteins and focus on the rapidly expanding field of transcriptional regulation of these inducible proteins, and closes with a discussion of drug discovery possibilities that target the regulation of leukocyte recruitment. This book will be of interest for any researchers, in academia or industry, looking for an overview of leukocyte recruitment or novel approaches to drug discovery.
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Format: | Texto biblioteca |
Language: | eng |
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Boston, MA : Springer US : Imprint: Springer,
2001
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Subjects: | Medicine., Respiratory organs, Pathology., Veterinary medicine., Biochemistry., Microbiology., Medicine & Public Health., Veterinary Medicine., Biochemistry, general., Pneumology/Respiratory System., |
Online Access: | http://dx.doi.org/10.1007/978-1-4615-1565-4 |
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KOHA-OAI-TEST:1839082018-07-30T23:05:17ZLeukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control [electronic resource] : Insights for Drug Discovery / Collins, Tucker. editor. SpringerLink (Online service) textBoston, MA : Springer US : Imprint: Springer,2001.engThe localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules. Leukocyte Recruitment, Endothelial Cell Adhesion Molecules and Transcriptional Control: Insights for Drug Discovery outlines some of the cellular and molecular mechanisms of inflammation with contributions from top researchers. This volume provides an overview of three of these endothelial adhesion molecules, as examples of key mediators of leukocyte recruitment. It reviews the structure and regulation of these cell surface proteins and focus on the rapidly expanding field of transcriptional regulation of these inducible proteins, and closes with a discussion of drug discovery possibilities that target the regulation of leukocyte recruitment. This book will be of interest for any researchers, in academia or industry, looking for an overview of leukocyte recruitment or novel approaches to drug discovery.1. The Selectins in Leukocyte Recruitment -- 2. Transcriptional Regulation of the E-Selectin Gene -- 3. The Immunoglobulin Superfamily in Leukocyte Recruitment -- 4. Regulation of Intercellular Adhesion Molecule (ICAM) Gene Expression -- 5. Transcriptional Regulation of VCAM-1 -- 6. Activation of Nuclear Factor-KB -- 7. The Basal Transcriptional Apparatus -- 8. Therapeutic Regulation of Leukocyte Adhesion Molecule Expression -- 9. The NF-kB System and Drug Discovery.The localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules. Leukocyte Recruitment, Endothelial Cell Adhesion Molecules and Transcriptional Control: Insights for Drug Discovery outlines some of the cellular and molecular mechanisms of inflammation with contributions from top researchers. This volume provides an overview of three of these endothelial adhesion molecules, as examples of key mediators of leukocyte recruitment. It reviews the structure and regulation of these cell surface proteins and focus on the rapidly expanding field of transcriptional regulation of these inducible proteins, and closes with a discussion of drug discovery possibilities that target the regulation of leukocyte recruitment. This book will be of interest for any researchers, in academia or industry, looking for an overview of leukocyte recruitment or novel approaches to drug discovery.Medicine.Respiratory organsPathology.Veterinary medicine.Biochemistry.Microbiology.Medicine & Public Health.Pathology.Microbiology.Veterinary Medicine.Biochemistry, general.Pneumology/Respiratory System.Springer eBookshttp://dx.doi.org/10.1007/978-1-4615-1565-4URN:ISBN:9781461515654 |
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Medicine. Respiratory organs Pathology. Veterinary medicine. Biochemistry. Microbiology. Medicine & Public Health. Pathology. Microbiology. Veterinary Medicine. Biochemistry, general. Pneumology/Respiratory System. Medicine. Respiratory organs Pathology. Veterinary medicine. Biochemistry. Microbiology. Medicine & Public Health. Pathology. Microbiology. Veterinary Medicine. Biochemistry, general. Pneumology/Respiratory System. |
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Medicine. Respiratory organs Pathology. Veterinary medicine. Biochemistry. Microbiology. Medicine & Public Health. Pathology. Microbiology. Veterinary Medicine. Biochemistry, general. Pneumology/Respiratory System. Medicine. Respiratory organs Pathology. Veterinary medicine. Biochemistry. Microbiology. Medicine & Public Health. Pathology. Microbiology. Veterinary Medicine. Biochemistry, general. Pneumology/Respiratory System. Collins, Tucker. editor. SpringerLink (Online service) Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control [electronic resource] : Insights for Drug Discovery / |
description |
The localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules. Leukocyte Recruitment, Endothelial Cell Adhesion Molecules and Transcriptional Control: Insights for Drug Discovery outlines some of the cellular and molecular mechanisms of inflammation with contributions from top researchers. This volume provides an overview of three of these endothelial adhesion molecules, as examples of key mediators of leukocyte recruitment. It reviews the structure and regulation of these cell surface proteins and focus on the rapidly expanding field of transcriptional regulation of these inducible proteins, and closes with a discussion of drug discovery possibilities that target the regulation of leukocyte recruitment. This book will be of interest for any researchers, in academia or industry, looking for an overview of leukocyte recruitment or novel approaches to drug discovery. |
format |
Texto |
topic_facet |
Medicine. Respiratory organs Pathology. Veterinary medicine. Biochemistry. Microbiology. Medicine & Public Health. Pathology. Microbiology. Veterinary Medicine. Biochemistry, general. Pneumology/Respiratory System. |
author |
Collins, Tucker. editor. SpringerLink (Online service) |
author_facet |
Collins, Tucker. editor. SpringerLink (Online service) |
author_sort |
Collins, Tucker. editor. |
title |
Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control [electronic resource] : Insights for Drug Discovery / |
title_short |
Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control [electronic resource] : Insights for Drug Discovery / |
title_full |
Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control [electronic resource] : Insights for Drug Discovery / |
title_fullStr |
Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control [electronic resource] : Insights for Drug Discovery / |
title_full_unstemmed |
Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control [electronic resource] : Insights for Drug Discovery / |
title_sort |
leukocyte recruitment, endothelial cell adhesion molecules, and transcriptional control [electronic resource] : insights for drug discovery / |
publisher |
Boston, MA : Springer US : Imprint: Springer, |
publishDate |
2001 |
url |
http://dx.doi.org/10.1007/978-1-4615-1565-4 |
work_keys_str_mv |
AT collinstuckereditor leukocyterecruitmentendothelialcelladhesionmoleculesandtranscriptionalcontrolelectronicresourceinsightsfordrugdiscovery AT springerlinkonlineservice leukocyterecruitmentendothelialcelladhesionmoleculesandtranscriptionalcontrolelectronicresourceinsightsfordrugdiscovery |
_version_ |
1756265162132684800 |