Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development [electronic resource] /
Rationale for the Effective Use of Pharmacokinetics and Pharmacodynamics in Early Drug Development -- The Case for Preclinical Pharmacodynamics -- Utility of Kinetic, Dynamic, and Metabolic Data in Nonclinical Pharmacology/Toxicology Studies -- Preclinical Pharmacokinetic & Pharmacodynamic Studies -- Pharmacokinetics and Drug Metabolism in Animal Studies (ADME, Protein Binding, Mass Balance, Animal Models) -- Nonclinical Considerations: Disposition of Drugs -- Use of Acute Toxicity Data in the Design and Interpretation of Subchronic and Chronic Toxicity Studies -- Use of Pharmacokinetics and Pharmacodynamics in Preclinical Studies to Guide Dosage Escalation Schemes in Phase I Studies of Anticancer Drugs -- Use of Toxicokinetic Principles in Drug Development: Bridging Preclinical and Clinical Studies -- Methodology for Preclinical Pharmacodynamic Studies -- Preclinical Pharmacodynamics of Central Nervous System Active Agents -- Preclinical Pharmacodynamics of Antihypertensives -- Preclinical Pharmacodynamics of Anxiolytics: Effects of Chronic Benzodiazepine Administration -- Guidelines for Development of a New Diuretic Agent -- Preclinical Pharmacodynamics of Anti-Inflammatory Drugs -- Preclinical & Clinical Pharmacokinetics -- The Role of Pharmacokinetics in the Drug Development Process -- Implementation of an Effective Pharmacokinetics Research Program in Industry -- Pharmacoepidemiology, Population Pharmacokinetics and New Drug Development -- Assessment of Pharmacokinetic Drug Interactions in Clinical Drug Development -- Clinical Pharmacodynamics -- Pharmacokinetic/Pharmacodynamic Models and Methods -- Pharmacokinetic and Pharmacodynamic Modeling Applied to Anesthetic Drugs -- Pharmacodynamic/Pharmacokinetic Relationships for Rapidly Acting Drugs (NSAIDS) in Rheumatoid Arthritis: Problems and Preliminary Solutions -- The Value of Plasma-Warfarin Measurement -- Clinical Pharmacodynamics of Cardiovascular Agents: Focus on Sudden Cardiac Death -- The Benzodiazepines: Kinetic-Dynamic Relationships -- Application of Pharmacodynamics & Pharmacokinetics in the Drug Development Process -- The Integration of Pharmacodynamics and Pharmacokinetics in Rational Drug Development -- Concentration-Controlled Trials: Basic Concepts, Design, and Implementation -- Summary Report -- Opportunities for Integration of Pharmacokinetics, Pharmacodynamics and Toxicokinetics in Rational Drug Development.
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Format: | Texto biblioteca |
Language: | eng |
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Boston, MA : Springer US : Imprint: Springer,
1993
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Subjects: | Medicine., Pharmacy., Pharmacology., Biomedicine., Pharmacology/Toxicology., |
Online Access: | http://dx.doi.org/10.1007/978-1-4757-1520-0 |
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KOHA-OAI-TEST:1801742018-07-30T22:59:55ZIntegration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development [electronic resource] / Yacobi, Avraham. editor. Skelly, Jerome P. editor. Shah, Vinod P. editor. Benet, Leslie Z. editor. SpringerLink (Online service) textBoston, MA : Springer US : Imprint: Springer,1993.engRationale for the Effective Use of Pharmacokinetics and Pharmacodynamics in Early Drug Development -- The Case for Preclinical Pharmacodynamics -- Utility of Kinetic, Dynamic, and Metabolic Data in Nonclinical Pharmacology/Toxicology Studies -- Preclinical Pharmacokinetic & Pharmacodynamic Studies -- Pharmacokinetics and Drug Metabolism in Animal Studies (ADME, Protein Binding, Mass Balance, Animal Models) -- Nonclinical Considerations: Disposition of Drugs -- Use of Acute Toxicity Data in the Design and Interpretation of Subchronic and Chronic Toxicity Studies -- Use of Pharmacokinetics and Pharmacodynamics in Preclinical Studies to Guide Dosage Escalation Schemes in Phase I Studies of Anticancer Drugs -- Use of Toxicokinetic Principles in Drug Development: Bridging Preclinical and Clinical Studies -- Methodology for Preclinical Pharmacodynamic Studies -- Preclinical Pharmacodynamics of Central Nervous System Active Agents -- Preclinical Pharmacodynamics of Antihypertensives -- Preclinical Pharmacodynamics of Anxiolytics: Effects of Chronic Benzodiazepine Administration -- Guidelines for Development of a New Diuretic Agent -- Preclinical Pharmacodynamics of Anti-Inflammatory Drugs -- Preclinical & Clinical Pharmacokinetics -- The Role of Pharmacokinetics in the Drug Development Process -- Implementation of an Effective Pharmacokinetics Research Program in Industry -- Pharmacoepidemiology, Population Pharmacokinetics and New Drug Development -- Assessment of Pharmacokinetic Drug Interactions in Clinical Drug Development -- Clinical Pharmacodynamics -- Pharmacokinetic/Pharmacodynamic Models and Methods -- Pharmacokinetic and Pharmacodynamic Modeling Applied to Anesthetic Drugs -- Pharmacodynamic/Pharmacokinetic Relationships for Rapidly Acting Drugs (NSAIDS) in Rheumatoid Arthritis: Problems and Preliminary Solutions -- The Value of Plasma-Warfarin Measurement -- Clinical Pharmacodynamics of Cardiovascular Agents: Focus on Sudden Cardiac Death -- The Benzodiazepines: Kinetic-Dynamic Relationships -- Application of Pharmacodynamics & Pharmacokinetics in the Drug Development Process -- The Integration of Pharmacodynamics and Pharmacokinetics in Rational Drug Development -- Concentration-Controlled Trials: Basic Concepts, Design, and Implementation -- Summary Report -- Opportunities for Integration of Pharmacokinetics, Pharmacodynamics and Toxicokinetics in Rational Drug Development.Medicine.Pharmacy.Pharmacology.Biomedicine.Pharmacology/Toxicology.Pharmacy.Springer eBookshttp://dx.doi.org/10.1007/978-1-4757-1520-0URN:ISBN:9781475715200 |
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Medicine. Pharmacy. Pharmacology. Biomedicine. Pharmacology/Toxicology. Pharmacy. Medicine. Pharmacy. Pharmacology. Biomedicine. Pharmacology/Toxicology. Pharmacy. |
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Medicine. Pharmacy. Pharmacology. Biomedicine. Pharmacology/Toxicology. Pharmacy. Medicine. Pharmacy. Pharmacology. Biomedicine. Pharmacology/Toxicology. Pharmacy. Yacobi, Avraham. editor. Skelly, Jerome P. editor. Shah, Vinod P. editor. Benet, Leslie Z. editor. SpringerLink (Online service) Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development [electronic resource] / |
description |
Rationale for the Effective Use of Pharmacokinetics and Pharmacodynamics in Early Drug Development -- The Case for Preclinical Pharmacodynamics -- Utility of Kinetic, Dynamic, and Metabolic Data in Nonclinical Pharmacology/Toxicology Studies -- Preclinical Pharmacokinetic & Pharmacodynamic Studies -- Pharmacokinetics and Drug Metabolism in Animal Studies (ADME, Protein Binding, Mass Balance, Animal Models) -- Nonclinical Considerations: Disposition of Drugs -- Use of Acute Toxicity Data in the Design and Interpretation of Subchronic and Chronic Toxicity Studies -- Use of Pharmacokinetics and Pharmacodynamics in Preclinical Studies to Guide Dosage Escalation Schemes in Phase I Studies of Anticancer Drugs -- Use of Toxicokinetic Principles in Drug Development: Bridging Preclinical and Clinical Studies -- Methodology for Preclinical Pharmacodynamic Studies -- Preclinical Pharmacodynamics of Central Nervous System Active Agents -- Preclinical Pharmacodynamics of Antihypertensives -- Preclinical Pharmacodynamics of Anxiolytics: Effects of Chronic Benzodiazepine Administration -- Guidelines for Development of a New Diuretic Agent -- Preclinical Pharmacodynamics of Anti-Inflammatory Drugs -- Preclinical & Clinical Pharmacokinetics -- The Role of Pharmacokinetics in the Drug Development Process -- Implementation of an Effective Pharmacokinetics Research Program in Industry -- Pharmacoepidemiology, Population Pharmacokinetics and New Drug Development -- Assessment of Pharmacokinetic Drug Interactions in Clinical Drug Development -- Clinical Pharmacodynamics -- Pharmacokinetic/Pharmacodynamic Models and Methods -- Pharmacokinetic and Pharmacodynamic Modeling Applied to Anesthetic Drugs -- Pharmacodynamic/Pharmacokinetic Relationships for Rapidly Acting Drugs (NSAIDS) in Rheumatoid Arthritis: Problems and Preliminary Solutions -- The Value of Plasma-Warfarin Measurement -- Clinical Pharmacodynamics of Cardiovascular Agents: Focus on Sudden Cardiac Death -- The Benzodiazepines: Kinetic-Dynamic Relationships -- Application of Pharmacodynamics & Pharmacokinetics in the Drug Development Process -- The Integration of Pharmacodynamics and Pharmacokinetics in Rational Drug Development -- Concentration-Controlled Trials: Basic Concepts, Design, and Implementation -- Summary Report -- Opportunities for Integration of Pharmacokinetics, Pharmacodynamics and Toxicokinetics in Rational Drug Development. |
format |
Texto |
topic_facet |
Medicine. Pharmacy. Pharmacology. Biomedicine. Pharmacology/Toxicology. Pharmacy. |
author |
Yacobi, Avraham. editor. Skelly, Jerome P. editor. Shah, Vinod P. editor. Benet, Leslie Z. editor. SpringerLink (Online service) |
author_facet |
Yacobi, Avraham. editor. Skelly, Jerome P. editor. Shah, Vinod P. editor. Benet, Leslie Z. editor. SpringerLink (Online service) |
author_sort |
Yacobi, Avraham. editor. |
title |
Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development [electronic resource] / |
title_short |
Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development [electronic resource] / |
title_full |
Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development [electronic resource] / |
title_fullStr |
Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development [electronic resource] / |
title_full_unstemmed |
Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development [electronic resource] / |
title_sort |
integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development [electronic resource] / |
publisher |
Boston, MA : Springer US : Imprint: Springer, |
publishDate |
1993 |
url |
http://dx.doi.org/10.1007/978-1-4757-1520-0 |
work_keys_str_mv |
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